 | | DRUG: Dexamethasone | |
| Entry |
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| Name |
Dexamethasone (JP18/USP/INN);
Decadron (TN);
Maxidex (TN) |
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| Product |
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| Generic |
DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (ANI Pharmaceuticals), DEXAMETHASONE (Advanced Rx Pharmacy of Tennessee), DEXAMETHASONE (Advanced Rx Pharmacy of Tennessee), DEXAMETHASONE (Alvogen), DEXAMETHASONE (American Health Packaging), DEXAMETHASONE (Amneal Pharmaceuticals NY LLC), DEXAMETHASONE (Amneal Pharmaceuticals NY LLC), DEXAMETHASONE (Apotex Corp.), DEXAMETHASONE (AvKARE), DEXAMETHASONE (Bionpharma Inc.,), DEXAMETHASONE (Bionpharma Inc.,), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Cardinal Health 107), DEXAMETHASONE (Cardinal Health 107), DEXAMETHASONE (Chartwell RX), DEXAMETHASONE (Direct Rx), DEXAMETHASONE (Direct Rx), DEXAMETHASONE (Direct_Rx), DEXAMETHASONE (Direct_Rx), DEXAMETHASONE (Direct_Rx), DEXAMETHASONE (Direct_Rx), DEXAMETHASONE (Doc Rx), DEXAMETHASONE (Golden State Medical Supply), DEXAMETHASONE (Key Therapeutics), DEXAMETHASONE (Larken Laboratories), DEXAMETHASONE (Larken Laboratories), DEXAMETHASONE (Major Pharmaceuticals), DEXAMETHASONE (NorthStar Rx LLC), DEXAMETHASONE (NuCare Pharmaceuticals), DEXAMETHASONE (NuCare Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (Prasco Laboratories), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Proficient Rx LP), DEXAMETHASONE (Proficient Rx LP), DEXAMETHASONE (Proficient Rx LP), DEXAMETHASONE (Proficient Rx LP), DEXAMETHASONE (Quality Care Products), DEXAMETHASONE (REMEDYREPACK), DEXAMETHASONE (REMEDYREPACK), DEXAMETHASONE (RedPharm Drug), DEXAMETHASONE (Redpharm Drug), DEXAMETHASONE (Redpharm Drug), DEXAMETHASONE (Rising Pharma Holdings), DEXAMETHASONE (Zydus Lifesciences Limited), DEXAMETHASONE (Zydus Lifesciences Limited), DEXAMETHASONE (Zydus Pharmaceuticals USA), DEXAMETHASONE (Zydus Pharmaceuticals USA), DEXAMETHASONE (medsource pharmaceuticals), DEXAMETHASONE INTENSOL (Hikma Pharmaceuticals USA), TAPERDEX 12-DAY (Proficient Rx LP), TAPERDEX 6-DAY (Proficient Rx LP) |
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| Formula |
C22H29FO5
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| Exact mass |
392.1999
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| Mol weight |
392.4611
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
| Product (mixture): | D08733<JP> D10296<US> D11177<US> D11178<US> |
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| Efficacy |
Anti-inflammatory, Antipruritic, Glucocorticoid receptor agonist |
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| Disease |
Diabetic macular edema [DS: H01651] Asthma [DS: H00079] Atopic dermatitis [DS: H01358] Contact dermatitis [DS: H01357] Allergic rhinitis [DS: H01360] Bullous dermatitis herpetiformis [DS: H01362] Mycosis fungoides [DS: H01463] Pemphigus [DS: H01648] Erythema multiforme [DS: H01695] Stevens-Johnson syndrome [DS: H01694] Congenital adrenal hyperplasia [DS: H00216] Ulcerative colitis [DS: H01466] Acquired (autoimmune) hemolytic anemia [DS: H01585] Congenital (erythroid) hypoplastic anemia; Diamond-Blackfan anemia [DS: H00237] Pure red cell aplasia [DS: H01586] Multiple sclerosis [DS: H01490] Temporal arteritis [DS: H01698] Nephrotic syndrome [DS: H01657] Pulmonary tuberculosis [DS: H00342] Acute gouty arthritis [DS: H01532] Ankylosing spondylitis [DS: H01674] Psoriatic arthritis [DS: H01507] Rheumatoid arthritis [DS: H00630] Juvenile rheumatoid arthritis [DS: H01672] Dermatomyositis and polymyositis [DS: H01604] Systemic lupus erythematosus [DS: H00080] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Dexamethasone
D00292 Dexamethasone (JP18/USP/INN)
Inflammatory Bowel Disease Agents
Glucocorticoids
Dexamethasone
D00292 Dexamethasone (JP18/USP/INN)
Ophthalmic Agents
Ophthalmic Anti-inflammatories
Glucocorticoids, Ophthalmic
Dexamethasone
D00292 Dexamethasone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1315 Ophthalmic cortisones
D00292 Dexamethasone (JP18/USP/INN)
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2399 Others
D00292 Dexamethasone (JP18/USP/INN)
24 Hormones
245 Adrenal hormone preparations
2454 Fluorinated adrenocorticotropic hormones
D00292 Dexamethasone (JP18/USP/INN)
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D00292 Dexamethasone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00292 Dexamethasone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Dexamethasone
D00292 Dexamethasone (JP18/USP/INN)
Second-class OTC drugs
Inorganic and organic chemicals
Dexamethasone
D00292 Dexamethasone (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D00292 Dexamethasone
Dermatological agent
DG03243 Atopic dermatitis agent
D00292 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D00292 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D00292 Dexamethasone
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00292 Dexamethasone
Dermatological agent
DG03243 Atopic dermatitis agent
D00292 Dexamethasone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00292 Dexamethasone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00292 Dexamethasone
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00292
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00292
Topical steroids potency [br08317.html]
Classification in Japan
D00292
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| KCF data |
ATOM 28
1 C2x C 6.5292 -16.7310
2 C5x C 6.5292 -18.0917
3 C2x C 7.7075 -18.7720
4 C2y C 8.8859 -18.0917
5 C1z C 8.8859 -16.7310
6 C2x C 7.7075 -16.0507
7 C1x C 10.0643 -18.7720
8 C1x C 11.2426 -18.0917
9 C1y C 11.2426 -16.7310
10 C1z C 10.0643 -16.0507
11 C1y C 12.4210 -16.0507
12 C1z C 12.4210 -14.6900
13 C1x C 11.2426 -14.0097
14 C1y C 10.0643 -14.6900
15 C1x C 14.7777 -16.0507
16 C1y C 14.7777 -14.6900
17 C1z C 13.5994 -14.0097
18 C1a C 8.8859 -15.3703
19 O1a O 8.8879 -14.0109
20 C1a C 12.4210 -13.3294
21 C1a C 15.9436 -14.0168
22 C5a C 13.5994 -12.3089
23 X F 10.0643 -17.4113
24 O1a O 14.7777 -13.1194
25 O5x O 5.3509 -18.7720
26 O5a O 14.7817 -11.6263
27 C1b C 12.4249 -11.6308
28 O1a O 11.2650 -12.3007
BOND 31
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 5 18 1 #Up
22 14 19 1 #Up
23 12 20 1 #Up
24 16 21 1 #Down
25 17 22 1 #Up
26 10 23 1 #Down
27 17 24 1 #Down
28 2 25 2
29 22 26 2
30 22 27 1
31 27 28 1
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