 | | DRUG: Diazepam | |
| Entry |
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| Name |
Diazepam (JP18/USP/INN);
Diastat (TN);
Valium (TN) |
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| Product |
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| Generic |
DIAZEPAM (A-S Medication Solutions), DIAZEPAM (A-S Medication Solutions), DIAZEPAM (A-S Medication Solutions), DIAZEPAM (A-S Medication Solutions), DIAZEPAM (Advanced Rx Pharmacy of Tennessee), DIAZEPAM (Advanced Rx Pharmacy of Tennessee), DIAZEPAM (American Health Packaging), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Asclemed USA), DIAZEPAM (Aurobindo Pharma Limited), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Cardinal Health 107), DIAZEPAM (Chartwell RX), DIAZEPAM (Civica), DIAZEPAM (Clinical Solutions Wholesale), DIAZEPAM (Clinical Solutions Wholesale), DIAZEPAM (Clinical Solutions Wholesale), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (Direct_Rx), DIAZEPAM (Fresenius Kabi USA), DIAZEPAM (Henry Schein), DIAZEPAM (Henry Schein), DIAZEPAM (Hikma Pharmaceuticals USA), DIAZEPAM (Hikma Pharmaceuticals USA), DIAZEPAM (Hikma Pharmaceuticals USA), DIAZEPAM (Hospira), DIAZEPAM (Hospira), DIAZEPAM (Lupin Pharmaceuticals), DIAZEPAM (Major Pharmaceuticals), DIAZEPAM (Mayne Pharma Commercial LLC), DIAZEPAM (Medical Purchasing Solutions), DIAZEPAM (Medical Purchasing Solutions), DIAZEPAM (Medsource Pharmaceuticals), DIAZEPAM (Medsource Pharmaceuticals), DIAZEPAM (Medsource Pharmaceuticals), DIAZEPAM (Mylan Institutional), DIAZEPAM (Mylan Pharmaceuticals), DIAZEPAM (Natco Pharma USA LLC), DIAZEPAM (Natco Pharma USA LLC), DIAZEPAM (Natco Pharma USA LLC), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (NuCare Pharmaceuticals), DIAZEPAM (Oceanside Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (Pharmaceutical Associates), DIAZEPAM (Precision Dose), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Proficient Rx LP), DIAZEPAM (Proficient Rx LP), DIAZEPAM (Proficient Rx LP), DIAZEPAM (Proficient Rx LP), DIAZEPAM (Quality Care Products LLC), DIAZEPAM (Quality Care Products LLC), DIAZEPAM (Quality Care Products), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (REMEDYREPACK), DIAZEPAM (RPK Pharmaceuticals), DIAZEPAM (Teva Pharmaceuticals USA), DIAZEPAM INTENSOL (Hikma Pharmaceuticals USA) |
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| Formula |
C16H13ClN2O
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| Exact mass |
284.0716
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| Mol weight |
284.7402
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG01567 GABA-A receptor agonist
DG01914 Anxiolytics, benzodiazepine derivatives
DG03199 Antiepileptic agent
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
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| Efficacy |
Antianxiety, Minor tranquilizer, Sedative-hypnotic |
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| Disease |
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| Comment |
Benzodiazepine derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BA Benzodiazepine derivatives
N05BA01 Diazepam
D00293 Diazepam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
Gamma-aminobutyric Acid (GABA) Augmenting Agents
Benzodiazepines
Diazepam
D00293 Diazepam (JP18/USP/INN)
Anxiolytics
Benzodiazepines
Diazepam
D00293 Diazepam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D00293 Diazepam (JP18/USP/INN)
113 Antiepileptics
1139 Others
D00293 Diazepam (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
D00293 Diazepam
DG01567 GABA-A receptor agonist
D00293 Diazepam
DG01914 Anxiolytics, benzodiazepine derivatives
D00293 Diazepam
DG03199 Antiepileptic agent
D00293 Diazepam
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
D00293 Diazepam
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00293 Diazepam
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D00293 Diazepam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D00293 Diazepam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00293 Diazepam
D00293 Diazepam tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00293
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00293
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Control Act Article 2 Table 31 (10 substances)
D00293
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| Other DBs |
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| KCF data |
ATOM 20
1 C2y C 17.4934 -14.8494
2 C8y C 16.6513 -13.7398
3 C8y C 16.9865 -12.3830
4 N1y N 18.2475 -11.8049
5 N2x N 18.8992 -14.8746
6 C5x C 19.5011 -12.4272
7 C1x C 19.7876 -13.7959
8 C8x C 15.9794 -11.4146
9 C8x C 14.6374 -11.8027
10 C8y C 14.3022 -13.1595
11 C8x C 15.3093 -14.1276
12 O5x O 20.5452 -11.4928
13 X Cl 12.9374 -13.5539
14 C8y C 16.8589 -16.0991
15 C8x C 15.4573 -16.0991
16 C1a C 18.2692 -10.4300
17 C8x C 14.7573 -17.3116
18 C8x C 15.4573 -18.5240
19 C8x C 16.8589 -18.5240
20 C8x C 17.5589 -17.3116
BOND 22
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 6 12 2
14 10 13 1
15 1 14 1
16 14 15 1
17 4 16 1
18 15 17 2
19 17 18 1
20 18 19 2
21 19 20 1
22 14 20 2
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