KEGG DRUG: Diazoxide

DRUG: Diazoxide

Entry

D00294                      Drug

Name

Diazoxide (JAN/USP/INN);
Hyperstat (TN);
Proglycem (TN)

Product

PROGLYCEM (Teva Pharmaceuticals USA)

Generic

DIAZOXIDE (Par Pharmaceutical), DIAZOXIDE (e5 Pharma)

Formula

C8H7ClN2O2S

Exact mass

229.9917

Mol weight

230.6714

Structure

Simcomp

Class

Cardiovascular agent
DG01583 ATP-sensitive potassium channel opener

Remark

Same as:

C06949

Therapeutic category:

3999

ATC code:

C02DA01 V03AH01

Product:

D00294<JP/US>

Efficacy

Antihypoglycemia, Antihypertensive, ATP-sensitive potassium channel opener

Disease

Hypoglycemia due to hyperinsulinism [DS:H01267]

Target

ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]

Pathway

hsa04911

Insulin secretion

Interaction

Structure map

map07232

Potassium channel blocking and opening drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
    C02DA Thiazide derivatives
     C02DA01 Diazoxide
      D00294  Diazoxide (JAN/USP/INN) <JP/US>
V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AH Drugs for treatment of hypoglycemia
     V03AH01 Diazoxide
      D00294  Diazoxide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
  Glycemic Agents
   Diazoxide
    D00294  Diazoxide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D00294  Diazoxide (JAN/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01583  ATP-sensitive potassium channel opener
   D00294  Diazoxide
Target-based classification of drugs [BR:br08310]
Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D00294  Diazoxide (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00294

Other DBs

CAS:

364-98-7

PubChem:

7847360

ChEBI:

4495

PDB-CCD:

20J[PDBj]

LigandBox:

D00294

NIKKAJI:

J5.703G

KCF data

ATOM        14
            1   C8y C    14.1400  -23.8000
            2   C8y C    14.1400  -25.2000
            3   C8x C    15.3524  -25.9000
            4   C8x C    16.5649  -25.2000
            5   C8y C    16.5649  -23.8000
            6   C8x C    15.3524  -23.1000
            7   S2x S    12.9276  -23.1000
            8   N4x N    11.7151  -23.8000
            9   C8y C    11.7151  -25.2000
            10  N5x N    12.9276  -25.9000
            11  X   Cl   17.7960  -23.0890
            12  C1a C    10.4840  -25.9110
            13  O3c O    13.9175  -22.1101
            14  O3c O    11.9376  -22.1101
BOND        15
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    5  11 1
            13    9  12 1
            14    7  13 2
            15    7  14 2

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