 | | DRUG: Digoxin | |
| Entry |
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| Name |
Digoxin (JP18/USP);
Lanoxicaps (TN);
Lanoxin (TN) |
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| Product |
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| Generic |
DIGOX (Proficient Rx LP), DIGOXIN (A-S Medication Solutions), DIGOXIN (A-S Medication Solutions), DIGOXIN (A-S Medication Solutions), DIGOXIN (A-S Medication Solutions), DIGOXIN (American Health Packaging), DIGOXIN (Amici Pharmaceuticals), DIGOXIN (Amneal Pharmaceuticals NY LLC), DIGOXIN (Amneal Pharmaceuticals of New York LLC), DIGOXIN (Aurobindo Pharma Limited), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Cardinal Health 107), DIGOXIN (Cardinal Health 107), DIGOXIN (General Injectables and Vaccines), DIGOXIN (Golden State Medical Supply), DIGOXIN (HF Acquisition Co LLC), DIGOXIN (Henry Schein), DIGOXIN (Hikma Pharmaceuticals USA), DIGOXIN (Hikma Pharmaceuticals USA), DIGOXIN (Hikma Pharmaceuticals USA), DIGOXIN (Major Pharmaceuticals), DIGOXIN (Marlex Pharmaceuticals), DIGOXIN (NCS HealthCare of KY), DIGOXIN (Northstar Rx LLC), DIGOXIN (Northwind Pharmaceuticals), DIGOXIN (Novitium Pharma LLC), DIGOXIN (Oliva Therapeutics), DIGOXIN (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (Sandoz), DIGOXIN (Sun Pharmaceutical Industries), DIGOXIN (VistaPharm) |
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| Formula |
C41H64O14
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| Exact mass |
780.4296
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| Mol weight |
780.9385
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| Structure |
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| Simcomp |
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| Class |
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| Remark |
| Therapeutic category: | 2113 |
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| Efficacy |
Cardiotonic |
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| Comment |
Digitalis glycoside
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| Target |
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
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| Metabolism |
Transporter: ABCB1 [HSA: 5243]
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| Interaction |
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| Structure map |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01A CARDIAC GLYCOSIDES
C01AA Digitalis glycosides
C01AA05 Digoxin
D00298 Digoxin (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Antiarrhythmics
Vaughn Williams-Class V
Digoxin
D00298 Digoxin (JP18/USP)
Cardiovascular Agents, Other
Digoxin
D00298 Digoxin (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
211 Cardiotonics
2113 Digitalis
D00298 Digoxin (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01698 Cardiac glycoside
DG01697 Digitalis cardiac glycoside
D00298 Digoxin
DG01653 Antiarrhythmics
D00298 Digoxin
Transporter substrate
DG01665 ABCB1 substrate
D00298 Digoxin
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D00298 Digoxin
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP1A
D00298 Digoxin (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00298 Digoxin
D00298 Digoxin tablets
D00298 Digoxin injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D00298
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| Other DBs |
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| KCF data |
ATOM 55
1 O2a O 19.8800 -19.5300
2 C1y C 21.0700 -18.7600
3 C1x C 22.2600 -19.4600
4 C1y C 23.4500 -18.7600
5 C1z C 23.4500 -17.3600
6 C1x C 22.2600 -16.6600
7 C1x C 21.0700 -17.3600
8 C1x C 24.7100 -19.4600
9 C1x C 25.9000 -18.7600
10 C1y C 25.9000 -17.3600
11 C1y C 24.7100 -16.6600
12 C1z C 27.0900 -16.6600
13 C1z C 27.0900 -15.2600
14 C1y C 25.9000 -14.5600
15 C1x C 24.7100 -15.2600
16 C1a C 27.0900 -13.8600
17 O1a O 27.0900 -18.0600
18 C1a C 23.4500 -15.9600
19 C1y C 18.6200 -18.9000
20 O2x O 18.6200 -17.5000
21 C1y C 17.3600 -16.8000
22 C1y C 16.1700 -17.5000
23 C1y C 16.1700 -18.9000
24 C1x C 17.3600 -19.6000
25 O2a O 14.9800 -16.8000
26 C1y C 13.7900 -17.5000
27 O2x O 13.7900 -18.9000
28 O1a O 14.9800 -19.6000
29 C1x C 12.5300 -16.8000
30 C1y C 11.3400 -17.5000
31 C1y C 11.3400 -18.9000
32 C1y C 12.5300 -19.6000
33 O1a O 10.1500 -16.8000
34 O2x O 8.8900 -17.5000
35 C1y C 8.8900 -18.9000
36 O2a O 10.1500 -19.6000
37 C1y C 7.7000 -16.8000
38 C1y C 6.5100 -17.5000
39 C1y C 6.5100 -18.9000
40 C1x C 7.7000 -19.6000
41 O1a O 5.2500 -16.8000
42 O1a O 5.2500 -19.6000
43 C1a C 17.3600 -15.4000
44 C1a C 12.5300 -21.0000
45 C1a C 7.7000 -15.4000
46 O1a O 25.9000 -13.1600
47 C1x C 29.5400 -16.6600
48 C1x C 29.5400 -15.2600
49 C1y C 28.2800 -14.5600
50 C2y C 28.2800 -13.1600
51 C2x C 29.7500 -13.1600
52 C7x C 30.1700 -11.8300
53 O7x O 29.0500 -10.9900
54 C1x C 27.9300 -11.7600
55 O6a O 31.5000 -11.4100
BOND 62
1 2 1 1 #Up
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 6 7 1
7 2 7 1
8 4 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 5 11 1
13 10 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 11 15 1
18 13 16 1 #Up
19 12 17 1 #Up
20 5 18 1 #Up
21 19 1 1 #Up
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 19 24 1
28 22 25 1 #Down
29 26 25 1 #Down
30 26 27 1
31 23 28 1 #Down
32 26 29 1
33 29 30 1
34 30 31 1
35 31 32 1
36 27 32 1
37 30 33 1 #Up
38 34 35 1
39 35 36 1 #Up
40 31 36 1 #Up
41 34 37 1
42 37 38 1
43 38 39 1
44 39 40 1
45 35 40 1
46 38 41 1 #Down
47 39 42 1 #Down
48 21 43 1 #Up
49 32 44 1 #Down
50 37 45 1 #Up
51 14 46 1 #Up
52 12 47 1
53 47 48 1
54 48 49 1
55 13 49 1
56 49 50 1 #Up
57 50 51 2
58 51 52 1
59 52 53 1
60 53 54 1
61 52 55 2
62 50 54 1
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