| Entry |
|
|---|
| Name |
Diphenhydramine (JP18/INN);
Restamin (TN) |
|---|
| Formula |
C17H21NO
|
|---|
| Exact mass |
255.1623
|
|---|
| Mol weight |
255.3547
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Remark |
| Therapeutic category: | 2642 |
| Product (DG00390): | D00300<JP> D00669<JP/US> D00520<JP/US> |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Comment |
Diphenhydramine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA32 Diphenhydramine
D00300 Diphenhydramine (JP18/INN) <JP>
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AA Aminoalkyl ethers
R06AA02 Diphenhydramine
D00300 Diphenhydramine (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2642 Antihistamines for external use
D00300 Diphenhydramine (JP18/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00300 Diphenhydramine (JP18/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Diphenhydramine
D00300 Diphenhydramine (JP18/INN)
Second-class OTC drugs
Inorganic and organic chemicals
Diphenhydramine
D00300 Diphenhydramine (JP18/INN)
Third-class OTC drugs
Inorganic and organic chemicals
Diphenhydramine
D00300 Diphenhydramine (JP18/INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00390 Diphenhydramine
D00300 Diphenhydramine
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D00300 Diphenhydramine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00300 Diphenhydramine (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00300 Diphenhydramine
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00390 Diphenhydramine
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 C1c C 30.1190 -16.7924
2 C8y C 28.9084 -17.4966
3 C8y C 31.3355 -17.4966
4 O2a O 30.1249 -15.3955
5 C8x C 28.9084 -18.8994
6 C8x C 27.6977 -16.7924
7 C8x C 31.3298 -18.8994
8 C8x C 32.5403 -16.7924
9 C1b C 31.3355 -14.6912
10 C8x C 27.6977 -19.5919
11 C8x C 26.4812 -17.4966
12 C8x C 32.5403 -19.5919
13 C8x C 33.7568 -17.4966
14 C8x C 26.4812 -18.8994
15 C8x C 33.7509 -18.8994
16 C1b C 32.5712 -15.4021
17 N1c N 33.7675 -14.7088
18 C1a C 34.9566 -15.3928
19 C1a C 33.7653 -13.3002
BOND 20
1 5 10 2
2 6 11 1
3 7 12 1
4 8 13 2
5 10 14 1
6 12 15 2
7 11 14 2
8 13 15 1
9 1 2 1
10 1 3 1
11 1 4 1
12 2 5 1
13 2 6 2
14 3 7 2
15 3 8 1
16 4 9 1
17 9 16 1
18 16 17 1
19 17 18 1
20 17 19 1
|
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