| Entry |
|
|---|
| Name |
Disopyramide (JP18/USAN/INN);
Rythmodan P (TN) |
|---|
| Formula |
C21H29N3O
|
|---|
| Exact mass |
339.2311
|
|---|
| Mol weight |
339.4745
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2129 |
| Product (DG00194): | D00303<JP> D00637<JP/US> |
|
|---|
| Efficacy |
Antiarrhythmic, Sodium channel blocker |
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BA Antiarrhythmics, class Ia
C01BA03 Disopyramide
D00303 Disopyramide (JP18/USAN/INN) <JP>
USP drug classification [BR:br08302]
Cardiovascular Agents
Antiarrhythmics
Vaughn Williams-Class I
Disopyramide
D00303 Disopyramide (JP18/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D00303 Disopyramide (JP18/USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00194 Disopyramide
D00303 Disopyramide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00194 Disopyramide
D00303 Disopyramide
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D00303 Disopyramide
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00303 Disopyramide (JP18/USAN/INN) <JP>
SCN2A
D00303 Disopyramide (JP18/USAN/INN) <JP>
SCN3A
D00303 Disopyramide (JP18/USAN/INN) <JP>
SCN4A
D00303 Disopyramide (JP18/USAN/INN) <JP>
SCN5A
D00303 Disopyramide (JP18/USAN/INN) <JP>
SCN8A
D00303 Disopyramide (JP18/USAN/INN) <JP>
SCN9A
D00303 Disopyramide (JP18/USAN/INN) <JP>
SCN10A
D00303 Disopyramide (JP18/USAN/INN) <JP>
SCN11A
D00303 Disopyramide (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00303 Disopyramide
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00303
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00194 Disopyramide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00194 Disopyramide
|
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| Other DBs |
|
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| KCF data |
ATOM 25
1 C8x C 22.8200 -18.9000
2 C8x C 22.8200 -20.3000
3 C8x C 24.0324 -21.0000
4 N5x N 25.2449 -20.3000
5 C8y C 25.2449 -18.9000
6 C8x C 24.0324 -18.2000
7 C8x C 27.6697 -20.3000
8 C8y C 27.6697 -18.9000
9 C1d C 26.4573 -18.2000
10 C8x C 28.8822 -21.0000
11 C8x C 30.0946 -20.3000
12 C8x C 30.0946 -18.9000
13 C8x C 28.8822 -18.2000
14 C1b C 26.4573 -16.8000
15 C1b C 27.6718 -16.0988
16 C5a C 24.4049 -17.0800
17 N1a N 24.4049 -15.6800
18 O5a O 23.2168 -17.7786
19 N1c N 27.6718 -14.5602
20 C1c C 28.8679 -13.8695
21 C1c C 26.4430 -13.8506
22 C1a C 25.2393 -14.5455
23 C1a C 26.4432 -12.4601
24 C1a C 30.0553 -14.5551
25 C1a C 28.8680 -12.4603
BOND 26
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 1
16 14 15 1
17 9 16 1
18 16 17 1
19 16 18 2
20 15 19 1
21 19 20 1
22 19 21 1
23 21 22 1
24 21 23 1
25 20 24 1
26 20 25 1
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