| Entry |
|
|---|
| Name |
Estazolam (JP18/USP/INN);
ProSom (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C16H11ClN4
|
|---|
| Exact mass |
294.0672
|
|---|
| Mol weight |
294.7383
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG03202 Hypnotic
DG01567 GABA-A receptor agonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1124 |
|
|---|
| Efficacy |
Sedative-hypnotic |
|---|
| Disease |
|
|---|
| Comment |
Benzodiazepine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CD Benzodiazepine derivatives
N05CD04 Estazolam
D00311 Estazolam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
Sleep Promoting Agents
Estazolam
D00311 Estazolam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D00311 Estazolam (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
D00311 Estazolam
DG03202 Hypnotic
D00311 Estazolam
DG01567 GABA-A receptor agonist
D00311 Estazolam
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
D00311 Estazolam
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03202 Hypnotic
D00311 Estazolam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D00311 Estazolam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00311 Estazolam
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00311
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D00311
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 21
1 C2y C 14.0634 -14.3594
2 C8y C 13.2213 -13.2498
3 C8y C 13.5565 -11.8930
4 N4y N 14.8175 -11.3149
5 N2x N 15.4692 -14.3846
6 C8y C 16.0711 -11.9372
7 C1x C 16.3576 -13.3059
8 C8x C 12.5494 -10.9246
9 C8x C 11.2074 -11.3127
10 C8y C 10.8722 -12.6695
11 C8x C 11.8793 -13.6376
12 X Cl 9.5074 -13.0639
13 C8y C 13.4289 -15.6091
14 C8x C 12.0273 -15.6091
15 C8x C 11.3273 -16.8216
16 C8x C 12.0273 -18.0340
17 C8x C 13.4289 -18.0340
18 C8x C 14.1289 -16.8216
19 N5x N 17.0504 -10.9373
20 N5x N 16.4020 -9.5570
21 C8x C 14.8175 -9.9149
BOND 24
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 10 12 1
14 1 13 1
15 13 14 1
16 14 15 2
17 15 16 1
18 16 17 2
19 17 18 1
20 13 18 2
21 6 19 2
22 19 20 1
23 4 21 1
24 21 20 2
|
|---|
