 | | DRUG: Felodipine | |
| Entry |
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| Name |
Felodipine (JP18/USP/INN);
Plendil (TN) |
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| Product |
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| Generic |
FELODIPINE (A-S Medication Solutions), FELODIPINE (Aurobindo Pharma Limited), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Carlsbad Technology), FELODIPINE (Chartwell RX), FELODIPINE (Glenmark Pharmaceuticals), FELODIPINE (Golden State Medical Supply), FELODIPINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), FELODIPINE (Par Pharmaceutical), FELODIPINE (Proficient Rx LP), FELODIPINE (Rising Pharma Holdings), FELODIPINE (Sun Pharmaceutical Industries), FELODIPINE (Torrent Pharmaceuticals Limited), FELODIPINE (Westminster Pharmaceuticals), FELODIPINE (Yiling Pharmaceutical) |
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| Formula |
C18H19Cl2NO4
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| Exact mass |
383.0691
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| Mol weight |
384.2538
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2149 |
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| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
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| Disease |
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| Comment |
Dihydropyridine derivative
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| Target |
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA02 Felodipine
D00319 Felodipine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Calcium Channel Blocking Agents, Dihydropyridines
Felodipine
D00319 Felodipine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D00319 Felodipine (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
D00319 Felodipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D00319 Felodipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00319 Felodipine
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D00319 Felodipine
DG03231 Antihypertensive
D00319 Felodipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D00319 Felodipine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00319 Felodipine
D00319 Felodipine tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00319
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| Other DBs |
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| KCF data |
ATOM 25
1 C1y C 23.3929 -16.6407
2 C8y C 23.3752 -18.9159
3 C2y C 22.2113 -15.9623
4 C2y C 24.5742 -15.9682
5 C8y C 22.1879 -19.5944
6 C8x C 24.5567 -19.6061
7 C2y C 22.2173 -14.5937
8 C7a C 21.0240 -16.6350
9 C2y C 24.5801 -14.6054
10 C7a C 25.7498 -16.6524
11 C8y C 22.1879 -20.9630
12 X Cl 21.0066 -18.9101
13 C8x C 24.5508 -20.9630
14 N1x N 23.3986 -13.9152
15 C1a C 21.0357 -13.9095
16 O7a O 19.8485 -15.9565
17 O6a O 21.0240 -18.0093
18 C1a C 25.7615 -13.9212
19 O7a O 26.9371 -15.9799
20 O6a O 25.7440 -18.0210
21 C8x C 23.3635 -21.6473
22 X Cl 21.0006 -21.6473
23 C1b C 18.6671 -16.6350
24 C1a C 28.1186 -16.6641
25 C1a C 17.4856 -15.9506
BOND 26
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 2
13 7 14 1
14 7 15 1
15 8 16 1
16 8 17 2
17 9 18 1
18 10 19 1
19 10 20 2
20 11 21 2
21 11 22 1
22 16 23 1
23 19 24 1
24 23 25 1
25 9 14 1
26 13 21 1
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