KEGG   DRUG: Finasteride
Entry
D00321                      Drug                                   
Name
Finasteride (JAN/USP/INN);
Propecia (TN);
Proscar (TN)
Product
  Generic
FINASTERIDE (A-S Medication Solutions), FINASTERIDE (A-S Medication Solutions), FINASTERIDE (A-S Medication Solutions), FINASTERIDE (A-S Medication Solutions), FINASTERIDE (A-S Medication Solutions), FINASTERIDE (A-S Medication Solutions), FINASTERIDE (Accord Healthcare), FINASTERIDE (Accord Healthcare), FINASTERIDE (American Health Packaging), FINASTERIDE (Aphena Pharma Solutions - Tennessee), FINASTERIDE (Aphena Pharma Solutions - Tennessee), FINASTERIDE (Ascend Laboratories), FINASTERIDE (Ascend Laboratories), FINASTERIDE (Asclemed USA), FINASTERIDE (Asclemed USA), FINASTERIDE (Asclemed USA), FINASTERIDE (Aurobindo Pharma Limited), FINASTERIDE (Aurobindo Pharma Limited), FINASTERIDE (AvPAK), FINASTERIDE (Bryant Ranch Prepack), FINASTERIDE (Bryant Ranch Prepack), FINASTERIDE (Bryant Ranch Prepack), FINASTERIDE (Bryant Ranch Prepack), FINASTERIDE (Burel Pharmaceuticals), FINASTERIDE (Camber Pharmaceuticals), FINASTERIDE (Camber Pharmaceuticals), FINASTERIDE (Cardinal Health 107), FINASTERIDE (Cipla USA), FINASTERIDE (Direct_Rx), FINASTERIDE (Dr Reddys Laboratories), FINASTERIDE (Dr Reddys Laboratories), FINASTERIDE (Dr. Reddy's Laboratories Limited), FINASTERIDE (Dr. Reddy's Laboratories Limited), FINASTERIDE (Exelan Pharmaceuticals), FINASTERIDE (Legacy Pharmaceutical Packaging), FINASTERIDE (Major Pharmaceuticals), FINASTERIDE (NuCare Pharmaceuticals), FINASTERIDE (NuCare Pharmaceuticals), FINASTERIDE (NuCare Pharmaceuticals), FINASTERIDE (NuCare Pharmaceuticals), FINASTERIDE (NuCare Pharmaceuticals), FINASTERIDE (NuCare Pharmaceuticals), FINASTERIDE (NuCare Pharmaceuticals), FINASTERIDE (Preferred Pharmacetucals), FINASTERIDE (Preferred Pharmaceuticals), FINASTERIDE (Preferred Pharmaceuticals), FINASTERIDE (Preferred Pharmaceuticals), FINASTERIDE (Proficient Rx LP), FINASTERIDE (Proficient Rx LP), FINASTERIDE (Proficient Rx LP), FINASTERIDE (Proficient Rx LP), FINASTERIDE (QUALLENT PHARMACEUTICALS HEALTH LLC), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (Rising Health), FINASTERIDE (Rising Pharma Holdings), FINASTERIDE (Sun Pharmaceutical Industries), FINASTERIDE (Sun Pharmaceutical Industries), FINASTERIDE (Teva Pharmaceuticals USA), FINASTERIDE (Thirty Madison), FINASTERIDE (Thirty Madison), FINASTERIDE (Zydus Lifesciences Limited), FINASTERIDE (Zydus Pharmaceuticals USA)
Formula
C23H36N2O2
Exact mass
372.2777
Mol weight
372.5441
Structure
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2499
ATC code: D11AX10 G04CB01
Product: D00321<JP/US>
Product (mixture): D12486<US>
Efficacy
Antiandrogen, 5alpha-Reductase inhibitor
Target
SRD5A2 [HSA:6716] [KO:K12344]
  Pathway
hsa00140  Steroid hormone biosynthesis
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX10 Finasteride
      D00321  Finasteride (JAN/USP/INN) <JP/US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CB Testosterone-5-alpha reductase inhibitors
     G04CB01 Finasteride
      D00321  Finasteride (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatological Agents, Other
   Dermatological Agents, Miscellaneous
    Finasteride
     D00321  Finasteride (JAN/USP/INN)
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Finasteride
    D00321  Finasteride (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D00321  Finasteride (JAN/USP/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00321  Finasteride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    SRD5A2
     D00321  Finasteride (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00321
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00321
Other DBs
CAS: 98319-26-7
PubChem: 7847387
ChEBI: 5062
PDB-CCD: FIT[PDBj]
LigandBox: D00321
NIKKAJI: J367.472J
KCF data

ATOM        27
            1   C1y C    25.2062  -19.0694
            2   C1y C    24.0333  -19.7462
            3   C1z C    25.2236  -17.7159
            4   C1x C    27.5515  -19.0985
            5   C1y C    22.8607  -19.0518
            6   C1x C    24.0333  -21.1054
            7   C1y C    26.4022  -17.0506
            8   C1x C    24.0567  -17.0274
            9   C1a C    25.2469  -16.2980
            10  C1x C    27.5689  -17.7450
            11  C1z C    21.6763  -19.7345
            12  C1x C    22.8723  -17.6983
            13  C1x C    22.8490  -21.7765
            14  C5a C    26.3963  -15.6563
            15  C1y C    21.6706  -21.0938
            16  C2x C    20.4979  -19.0518
            17  C1a C    21.6822  -18.3576
            18  N1b N    25.2293  -14.9621
            19  O5a O    27.5865  -14.9912
            20  N1x N    20.4979  -21.7705
            21  C2x C    19.3252  -19.7345
            22  C1d C    24.0567  -14.1919
            23  C5x C    19.3252  -21.0938
            24  C1a C    22.9600  -13.5035
            25  C1a C    23.2924  -15.2304
            26  C1a C    24.8094  -13.0893
            27  O5x O    18.1409  -21.7705
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   14  18 1
            18   14  19 2
            19   15  20 1
            20   16  21 2
            21   18  22 1
            22   20  23 1
            23   22  24 1
            24   22  25 1
            25   22  26 1
            26   23  27 2
            27    7  10 1
            28    8  12 1
            29   13  15 1
            30   21  23 1

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