KEGG DRUG: Flucytosine

DRUG: Flucytosine

Entry

D00323                      Drug

Name

Flucytosine (JP18/USP/INN);
Ancobon (TN)

Abbr

5FC

Product

ANCOBON (Bausch Health US LLC)

Generic

FLUCYTOSINE (American Health Packaging), FLUCYTOSINE (Aurobindo Pharma Limited), FLUCYTOSINE (AvPAK), FLUCYTOSINE (Bryant Ranch Prepack), FLUCYTOSINE (Bryant Ranch Prepack), FLUCYTOSINE (Bryant Ranch Prepack), FLUCYTOSINE (Bryant Ranch Prepack), FLUCYTOSINE (Bryant Ranch Prepack), FLUCYTOSINE (Bryant Ranch Prepack), FLUCYTOSINE (Cameron Pharmaceuticals), FLUCYTOSINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), FLUCYTOSINE (Hikma Pharmaceuticals USA), FLUCYTOSINE (Lupin Pharmaceuticals), FLUCYTOSINE (Major Pharmaceuticals), FLUCYTOSINE (Novel Laboratories), FLUCYTOSINE (Sigmapharm Laboratories)

Formula

C4H4FN3O

Exact mass

129.0338

Mol weight

129.0925

Structure

Simcomp

Remark

Therapeutic category:

6290

ATC code:

D01AE21 J02AX01

Product:

D00323<JP/US>

Efficacy

Antifungal, Nucleic acid biosynthesis inhibitor

Disease

Candidiasis [DS:H00363]
Cryptococcosis [DS:H00364]

Comment

Fluoropymidine derivative
Flucytosine is converted into Fluorouracil [DR:D00584] by susceptible fungal cells.

Target

TYMS [KO:K00560]

Pathway

ko00240

Pyrimidine metabolism

Interaction

Structure map

map07026

Antifungal agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AE Other antifungals for topical use
     D01AE21 Flucytosine
      D00323  Flucytosine (JP18/USP/INN) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AX Other antimycotics for systemic use
     J02AX01 Flucytosine
      D00323  Flucytosine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antifungals
  Flucytosine
   D00323  Flucytosine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D00323  Flucytosine (JP18/USP/INN)
Antimicrobials [BR:br08307]
Antifungals
  Nucleic acid synthesis inhibitor
   Fluoropyrimidine
    D00323  Flucytosine (JP18/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antifungals
  Nucleic acid synthesis inhibitor
   Fluoropyrimidine
    D00323  Flucytosine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00323  Flucytosine

Other DBs

CAS:

2022-85-7

PubChem:

7847389

ChEBI:

5100

PDB-CCD:

1LD[PDBj]

LigandBox:

D00323

NIKKAJI:

J3.695A

KCF data

ATOM        9
            1   C8y C    22.2270  -17.0929
            2   C8y C    23.4436  -16.4001
            3   N5x N    22.2270  -18.4957
            4   N1a N    21.0104  -16.3943
            5   C8x C    24.6486  -17.0929
            6   X   F    23.4436  -14.9972
            7   C8y C    23.4436  -19.1943
            8   N4x N    24.6486  -18.4957
            9   O5x O    23.4436  -20.5971
BOND        9
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     5   8 1
            8     7   9 2
            9     7   8 1

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