| Entry |
|
|---|
| Name |
Flurbiprofen (JP18/USP/INN);
Ansaid (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C15H13FO2
|
|---|
| Exact mass |
244.09
|
|---|
| Mol weight |
244.2609
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
| Product (DG00755): | D00330<JP/US> D01475<JP> D02290<US> |
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, COX inhibitor |
|---|
| Disease |
Rheumatoid arthritis [DS: H00630] |
|---|
| Comment |
Propionic acid derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE09 Flurbiprofen
D00330 Flurbiprofen (JP18/USP/INN) <JP/US>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA19 Flurbiprofen
D00330 Flurbiprofen (JP18/USP/INN) <JP/US>
R RESPIRATORY SYSTEM
R02 THROAT PREPARATIONS
R02A THROAT PREPARATIONS
R02AX Other throat preparations
R02AX01 Flurbiprofen
D00330 Flurbiprofen (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC04 Flurbiprofen
D00330 Flurbiprofen (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Flurbiprofen
D00330 Flurbiprofen (JP18/USP/INN)
Ophthalmic Agents
Ophthalmic Anti-inflammatories
Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
Flurbiprofen
D00330 Flurbiprofen (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D00330 Flurbiprofen (JP18/USP/INN)
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2649 Others
D00330 Flurbiprofen (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Drugs requiring guidance
New approved switch OTC drugs
Flurbiprofen
D00330 Flurbiprofen (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00755 Flurbiprofen
D00330 Flurbiprofen
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00755 Flurbiprofen
D00330 Flurbiprofen
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D00330 Flurbiprofen
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D00330 Flurbiprofen (JP18/USP/INN) <JP/US>
PTGS2 (COX2)
D00330 Flurbiprofen (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00330 Flurbiprofen
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00330
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00330
Prodrugs [br08324.html]
D00330
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00755 Flurbiprofen
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00755 Flurbiprofen
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 18
1 C8x C 28.9100 -18.0600
2 C8y C 28.9100 -16.6600
3 C8x C 27.6500 -15.9600
4 C8x C 26.4600 -16.6600
5 C8x C 26.4600 -18.0600
6 C8x C 27.6500 -18.7600
7 C8y C 30.1000 -15.9600
8 C8y C 31.2900 -16.6600
9 C8x C 32.5500 -15.9600
10 C8y C 32.5500 -14.5600
11 C8x C 31.2900 -13.8600
12 C8x C 30.1000 -14.5600
13 X F 31.2900 -18.0600
14 C1c C 33.7400 -13.8600
15 C6a C 34.9300 -14.5600
16 C1a C 33.7400 -12.4600
17 O6a O 34.9300 -15.9600
18 O6a O 36.1900 -13.8600
BOND 19
1 4 5 2
2 5 6 1
3 7 8 2
4 8 9 1
5 9 10 2
6 10 11 1
7 11 12 2
8 12 7 1
9 6 1 2
10 8 13 1
11 10 14 1
12 2 7 1
13 14 15 1
14 1 2 1
15 14 16 1
16 2 3 2
17 15 17 2
18 3 4 1
19 15 18 1
|
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