 | | DRUG: Gemfibrozil | |
| Entry |
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| Name |
Gemfibrozil (JAN/USP/INN);
Lopid (TN) |
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| Product |
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| Generic |
GEMFIBROZIL (A-S Medication Solutions), GEMFIBROZIL (A-S Medication Solutions), GEMFIBROZIL (A-S Medication Solutions), GEMFIBROZIL (American Health Packaging), GEMFIBROZIL (Aphena Pharma Solutions - Tennessee), GEMFIBROZIL (Aphena Pharma Solutions - Tennessee), GEMFIBROZIL (Aphena Pharma Solutions - Tennessee), GEMFIBROZIL (Ascent Pharmaceuticals), GEMFIBROZIL (Aurobindo Pharma Limited), GEMFIBROZIL (AvPAK), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Cadila Pharmaceuticals Limited), GEMFIBROZIL (Camber Pharmaceuticals), GEMFIBROZIL (Chartwell RX), GEMFIBROZIL (Cipla USA), GEMFIBROZIL (Denton Pharma), GEMFIBROZIL (Direct_Rx), GEMFIBROZIL (Epic Pharma), GEMFIBROZIL (Exelan Pharmaceuticals), GEMFIBROZIL (NCS HealthCare of KY), GEMFIBROZIL (Nivagen Pharmaceuticals), GEMFIBROZIL (NorthStar Rx LLC), GEMFIBROZIL (Northstar RxLLC), GEMFIBROZIL (Northwind Pharmaceuticals), GEMFIBROZIL (NuCare Pharmaceuticals), GEMFIBROZIL (NuCare Pharmaceuticals), GEMFIBROZIL (PD-Rx Pharmaceuticals), GEMFIBROZIL (PD-Rx Pharmaceuticals), GEMFIBROZIL (Preferred Pharmaceuticals), GEMFIBROZIL (Proficient Rx LP), GEMFIBROZIL (Proficient Rx LP), GEMFIBROZIL (Proficient Rx LP), GEMFIBROZIL (PuraCap Laboratories LLC dba Blu Pharmaceuticals), GEMFIBROZIL (REMEDYREPACK), GEMFIBROZIL (RPK Pharmaceuticals), GEMFIBROZIL (RPK Pharmaceuticals), GEMFIBROZIL (RPK Pharmaceuticals), GEMFIBROZIL (Rising Pharma Holdings), GEMFIBROZIL (Viona Pharmaceuticals), GEMFIBROZIL (XLCare Pharmaceuticals), GEMFIBROZIL (Zydus Lifesciences Limited), GEMFIBROZIL (Zydus Pharmaceuticals (USA)) |
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| Formula |
C15H22O3
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| Exact mass |
250.1569
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| Mol weight |
250.3334
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| Structure |
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| Simcomp |
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01733 PPAR alpha agonist
DG01547 Fibrate
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
Transporter inhibitor
DG02865 SLCO1B1 inhibitor
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| Remark |
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| Efficacy |
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist |
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| Disease |
Types IV and V hyperlipidemia [DS: H01635] |
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| Comment |
Clofibrate derivative
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| Target |
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| Pathway |
| hsa04920 | Adipocytokine signaling pathway |
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| Interaction |
CYP inhibition: CYP2C8 [HSA: 1558]
Transporter inhibition: SLCO1B1 [HSA: 10599]
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| Structure map |
| map07222 | Peroxisome proliferator-activated receptor (PPAR) agonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AB Fibrates
C10AB04 Gemfibrozil
D00334 Gemfibrozil (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, Fibric Acid Derivatives
Gemfibrozil
D00334 Gemfibrozil (JAN/USP/INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01733 PPAR alpha agonist
DG01547 Fibrate
D00334 Gemfibrozil
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
D00334 Gemfibrozil
Transporter inhibitor
DG02865 SLCO1B1 inhibitor
D00334 Gemfibrozil
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D00334 Gemfibrozil
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Peroxisome proliferator-activated receptor (PPAR)
NR1C1 (PPARA)
D00334 Gemfibrozil (JAN/USP/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00334
Drug transporters
D00334
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| Other DBs |
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| KCF data |
ATOM 18
1 C8x C 9.4500 -21.2100
2 C8x C 9.4500 -22.6100
3 C8y C 10.6624 -23.3100
4 C8y C 11.8749 -22.6100
5 C8x C 11.8749 -21.2100
6 C8y C 10.6624 -20.5100
7 C1a C 10.6624 -19.1102
8 C1a C 10.6624 -24.7098
9 O2a O 13.1060 -23.3210
10 C1b C 14.3112 -22.6253
11 C1b C 15.4935 -23.3081
12 C1b C 16.6875 -22.6188
13 C1d C 17.8754 -23.3048
14 C6a C 19.0665 -22.6171
15 O6a O 20.2559 -23.3039
16 O6a O 19.0667 -21.2103
17 C1a C 17.1178 -24.5033
18 C1a C 18.5957 -24.4949
BOND 18
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 3 8 1
9 4 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 14 15 1
16 14 16 2
17 13 17 1
18 13 18 1
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