KEGG   DRUG: Glipizide
Entry
D00335                      Drug                                   
Name
Glipizide (USP/INN);
Glucotrol (TN)
Product
  Generic
GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (ANI Pharmaceuticals), GLIPIZIDE (Accord Healthcare), GLIPIZIDE (Actavis Pharma), GLIPIZIDE (Actavis Pharma), GLIPIZIDE (Advagen Pharma Limited), GLIPIZIDE (American Health Packaging), GLIPIZIDE (American Health Packaging), GLIPIZIDE (American Health Packaging), GLIPIZIDE (American Health Packaging), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Apotex Corp.), GLIPIZIDE (Aurobindo Pharma Limited), GLIPIZIDE (Aurobindo Pharma Limited), GLIPIZIDE (AvPAK), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Cardinal Health 107), GLIPIZIDE (DIRECT RX), GLIPIZIDE (DIRECT RX), GLIPIZIDE (DIRECT RX), GLIPIZIDE (Denton Pharma), GLIPIZIDE (Denton Pharma), GLIPIZIDE (Denton Pharma), GLIPIZIDE (Direct_Rx), GLIPIZIDE (Direct_Rx), GLIPIZIDE (Golden State Medical Supply), GLIPIZIDE (Greenstone LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Legacy Pharmaceutical Packaging), GLIPIZIDE (Major Pharmaceuticals), GLIPIZIDE (Mylan Pharmaceuticals), GLIPIZIDE (NCS HealthCare of KY), GLIPIZIDE (NORTHWIND PHARMACEUTICALS), GLIPIZIDE (NorthStar RxLLC), GLIPIZIDE (Northstar Rx LLC.), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (NuCare Pharmaceuticals), GLIPIZIDE (NuCare Pharmaceuticals), GLIPIZIDE (NuCare Pharmaceuticals), GLIPIZIDE (NuCare Pharmaceuticals), GLIPIZIDE (NuCare Pharmaceuticals), GLIPIZIDE (NuCare Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals Inc..), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (QPharma), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (RPK Pharmaceuticals), GLIPIZIDE (RPK Pharmaceuticals), GLIPIZIDE (RPK Pharmaceuticals), GLIPIZIDE (RPK Pharmaceuticals), GLIPIZIDE (Redpharm drug), GLIPIZIDE (Rising Pharmaceuticals), GLIPIZIDE (ST. MARY'S MEDICAL PARK PHARMACY), GLIPIZIDE (St. Mary's Medical Park Pharmacy), GLIPIZIDE (St. Mary's Medical Park Pharmacy), GLIPIZIDE (St. Mary's Medical Park Pharmacy), GLIPIZIDE (TruPharma LLC), GLIPIZIDE (Zydus Lifesciences Limited), GLIPIZIDE (Zydus Pharmaceuticals USA), GLIPIZIDE ER (DIRECT RX)
Formula
C21H27N5O4S
Exact mass
445.1784
Mol weight
445.5352
Structure
Simcomp
Class
Antidiabetic agent
 DG01508  Sulfonylurea receptor agonist
  DG01734  Sulfonylurea
 DG02044  Hypoglycemic agent
  DG01734  Sulfonylurea
Remark
ATC code: A10BB07
Product: D00335<US>
Product (mixture): D10265<US>
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
  Disease
Type II diabetes mellitus [DS:H00409]
Comment
Sulfonylurea
Target
ABCC8 (SUR1) [HSA:6833] [KO:K05032]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Interaction
Structure map
map07018  Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB07 Glipizide
      D00335  Glipizide (USP/INN) <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Sulfonylureas
    Glipizide
     D00335  Glipizide (USP/INN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01508  Sulfonylurea receptor agonist
   DG01734  Sulfonylurea
    D00335  Glipizide
  DG02044  Hypoglycemic agent
   DG01734  Sulfonylurea
    D00335  Glipizide
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01734  Sulfonylurea
   D00335  Glipizide
  DG02044  Hypoglycemic agent
   D00335  Glipizide
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8 (SUR1)
     D00335  Glipizide (USP/INN) <US>
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00335
Other DBs
CAS: 29094-61-9
PubChem: 7847401
ChEBI: 5384
LigandBox: D00335
NIKKAJI: J20.336J
KCF data

ATOM        31
            1   C8y C    19.1800  -20.9300
            2   C8x C    17.9200  -20.2300
            3   C8x C    19.1800  -22.3300
            4   S4a S    20.3700  -20.2300
            5   C8x C    16.7300  -20.9300
            6   C8x C    17.9200  -23.0300
            7   N1b N    21.5600  -20.9300
            8   C8y C    16.7300  -22.3300
            9   C5a C    22.7500  -20.2300
            10  C1b C    15.5400  -23.0300
            11  N1b N    24.0100  -20.9300
            12  O5a O    22.7500  -18.8300
            13  C1b C    14.3500  -22.3300
            14  C1y C    25.2000  -20.2300
            15  N1b N    13.0900  -23.0300
            16  C1x C    25.2000  -18.8300
            17  C1x C    26.3900  -20.9300
            18  C5a C    11.9000  -22.3300
            19  C1x C    26.3900  -18.1300
            20  C1x C    27.5800  -20.2300
            21  C8y C    10.7100  -23.0300
            22  O5a O    11.9000  -20.9300
            23  C1x C    27.5800  -18.8300
            24  C8x C    10.7100  -24.4300
            25  N5x N     9.5200  -22.3300
            26  N5x N     9.5200  -25.1300
            27  C8x C     8.3300  -23.0300
            28  C8y C     8.3300  -24.4300
            29  C1a C     7.1400  -25.1300
            30  O3c O    21.0700  -19.0176
            31  O3c O    19.6700  -19.0176
BOND        33
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     7   9 1
            9     8  10 1
            10    9  11 1
            11    9  12 2
            12   10  13 1
            13   11  14 1
            14   13  15 1
            15   14  16 1
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21   18  22 2
            22   19  23 1
            23   21  24 1
            24   21  25 2
            25   24  26 2
            26   25  27 1
            27   26  28 1
            28   28  29 1
            29    6   8 1
            30   20  23 1
            31   27  28 2
            32    4  30 2
            33    4  31 2

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