KEGG   DRUG: Hydrochlorothiazide
Entry
D00340                      Drug                                   
Name
Hydrochlorothiazide (JP18/USP/INN);
Esidrix (TN);
Microzide (TN)
Product
  Generic
HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (A-S Medication Solutions), HYDROCHLOROTHIAZIDE (Accord Healthcare), HYDROCHLOROTHIAZIDE (Actavis Pharma), HYDROCHLOROTHIAZIDE (Actavis Pharma), HYDROCHLOROTHIAZIDE (Alembic Pharmaceuticals Limited), HYDROCHLOROTHIAZIDE (Alembic Pharmaceuticals), HYDROCHLOROTHIAZIDE (American Health Packaging), HYDROCHLOROTHIAZIDE (American Health Packaging), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aphena Pharma Solutions - Tennessee), HYDROCHLOROTHIAZIDE (Aurobindo Pharma Limited), HYDROCHLOROTHIAZIDE (Aurobindo Pharma Limited), HYDROCHLOROTHIAZIDE (AvPAK), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Chartwell RX), HYDROCHLOROTHIAZIDE (DIRECT RX), HYDROCHLOROTHIAZIDE (Denton Pharma), HYDROCHLOROTHIAZIDE (Denton Pharma), HYDROCHLOROTHIAZIDE (Denton Pharma), HYDROCHLOROTHIAZIDE (Direct RX), HYDROCHLOROTHIAZIDE (Direct_Rx), HYDROCHLOROTHIAZIDE (Direct_Rx), HYDROCHLOROTHIAZIDE (Direct_Rx), HYDROCHLOROTHIAZIDE (Exelan Pharmaceuticals), HYDROCHLOROTHIAZIDE (Golden State Medical Supply), HYDROCHLOROTHIAZIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), HYDROCHLOROTHIAZIDE (JUBILANT CADISTA PHARMACEUTICALS), HYDROCHLOROTHIAZIDE (Lake Erie Medical DBA Quality Care Products LLC), HYDROCHLOROTHIAZIDE (Lannett Company), HYDROCHLOROTHIAZIDE (Leading Pharma), HYDROCHLOROTHIAZIDE (Legacy Pharmaceutical Packaging), HYDROCHLOROTHIAZIDE (NCS HealthCare of KY), HYDROCHLOROTHIAZIDE (NCS HealthCare of KY), HYDROCHLOROTHIAZIDE (NCS HealthCare of KY), HYDROCHLOROTHIAZIDE (NCS HealthCare of KY), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (Northwind Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare PHarmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (NuCare Pharmaceuticals), HYDROCHLOROTHIAZIDE (Oxford Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (Proficient Rx LP), HYDROCHLOROTHIAZIDE (QPharma), HYDROCHLOROTHIAZIDE (QPharma), HYDROCHLOROTHIAZIDE (QPharma), HYDROCHLOROTHIAZIDE (QPharma), HYDROCHLOROTHIAZIDE (QPharma), HYDROCHLOROTHIAZIDE (Quality Care Products LLC), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (RPK Pharmaceuticals), HYDROCHLOROTHIAZIDE (RPK Pharmaceuticals), HYDROCHLOROTHIAZIDE (RPK Pharmaceuticals), HYDROCHLOROTHIAZIDE (Redpharm Drug), HYDROCHLOROTHIAZIDE (Redpharm drug), HYDROCHLOROTHIAZIDE (Rising Health), HYDROCHLOROTHIAZIDE (ST. MARY'S MEDICAL PARK PHARMACY), HYDROCHLOROTHIAZIDE (ScieGen Pharmaceuticals), HYDROCHLOROTHIAZIDE (ScieGen Pharmaceuticals), HYDROCHLOROTHIAZIDE (Solco Healthcare U.S.), HYDROCHLOROTHIAZIDE (St. Mary's Medical Park Pharmacy), HYDROCHLOROTHIAZIDE (St. Mary's Medical Park Pharmacy), HYDROCHLOROTHIAZIDE (St. Mary's Medical Park Pharmacy), HYDROCHLOROTHIAZIDE (St. Mary's Medical Park Pharmacy), HYDROCHLOROTHIAZIDE (Teva Pharmaceuticals USA), HYDROCHLOROTHIAZIDE (Unichem Pharmaceuticals (USA)), HYDROCHLOROTHIAZIDE (Unichem Pharmaceuticals (USA)), HYDROCHLOROTHIAZIDE (Westminster Pharmaceuticals)
Formula
C7H8ClN3O4S2
Exact mass
296.9645
Mol weight
297.7391
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG01749  Thiazide diuretic
 DG01690  Sulfonamide diuretic
  DG01749  Thiazide diuretic
Remark
Same as: C07041
Therapeutic category: 2132 2149
ATC code: C03AA03
Product: D00340<JP/US>
Product (mixture): D07895<JP/US> D09196<JP/US> D09197<JP/US> D09219<JP/US> D10249<US> D10268<US> D10269<US> D10270<US> D10271<US> D10273<US> D10275<US> D10276<US> D10277<US> D10278<US> D10279<US> D10280<US> D10284<US> D10286<US> D10288<US> D10805<JP>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Thiazides
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07233  Ion transporter inhibitors
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03A LOW-CEILING DIURETICS, THIAZIDES
    C03AA Thiazides, plain
     C03AA03 Hydrochlorothiazide
      D00340  Hydrochlorothiazide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Hydrochlorothiazide
    D00340  Hydrochlorothiazide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2132  Thiazides
     D00340  Hydrochlorothiazide (JP18/USP/INN)
   214  Antihypertensives
    2149  Others
     D00340  Hydrochlorothiazide (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01749  Thiazide diuretic
    D00340  Hydrochlorothiazide
  DG01690  Sulfonamide diuretic
   DG01749  Thiazide diuretic
    D00340  Hydrochlorothiazide
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00340  Hydrochlorothiazide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 (TSC)
     D00340  Hydrochlorothiazide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00340  Hydrochlorothiazide
Other DBs
CAS: 58-93-5
PubChem: 7847406
ChEBI: 5778
PDB-CCD: HCZ[PDBj]
LigandBox: D00340
NIKKAJI: J1.920H
KCF data

ATOM        17
            1   C8y C    22.4791  -15.9596
            2   C8y C    22.4731  -17.3165
            3   C8x C    23.6605  -15.2870
            4   S2x S    21.3034  -15.2811
            5   C8x C    23.6430  -18.0010
            6   N1x N    21.3034  -17.9950
            7   C8y C    24.8304  -15.9713
            8   N1x N    20.1278  -15.9596
            9   O3c O    19.9933  -14.4564
            10  O3c O    22.5376  -14.4564
            11  C8y C    24.8244  -17.3282
            12  C1x C    20.1278  -17.3165
            13  S4a S    26.0118  -15.2987
            14  X   Cl   26.0003  -18.0127
            15  N1a N    27.2636  -14.4623
            16  O3c O    27.1349  -16.3164
            17  O3c O    24.9357  -14.2516
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     4   9 2
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13   11  14 1
            14   13  15 1
            15   13  16 2
            16   13  17 2
            17    7  11 1
            18    8  12 1

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