| Entry |
|
|---|
| Name |
Ifosfamide (JAN/USP/INN);
Ifex (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C7H15Cl2N2O2P
|
|---|
| Exact mass |
260.0248
|
|---|
| Mol weight |
261.086
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG01677 Alkylating agent
DG01678 Nitrogen mustard analog
DG01720 Isophosphoramide mustard analog
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 4211 |
|
|---|
| Efficacy |
Antineoplastic, Alkylating agent |
|---|
| Disease |
|
|---|
| Comment |
Active form of prodrug: 4-Hydroxyifosfamide [CPD: C16553]
|
|---|
| Target |
DNA |
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07040 | Antineoplastics - alkylating agents |
|
|---|
| Other map |
| map00982 | Drug metabolism - cytochrome P450 |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01A ALKYLATING AGENTS
L01AA Nitrogen mustard analogues
L01AA06 Ifosfamide
D00343 Ifosfamide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Alkylating Agents
Ifosfamide
D00343 Ifosfamide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
421 Alkylating agents
4211 Chlorethylamines
D00343 Ifosfamide (JAN/USP/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01677 Alkylating agent
DG01678 Nitrogen mustard analog
DG01720 Isophosphoramide mustard analog
D00343 Ifosfamide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00343 Ifosfamide
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00343
Prodrugs [br08324.html]
D00343
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 14
1 P1a P 27.8304 -19.5949
2 N1b N 27.8362 -18.1152
3 N1y N 28.9741 -20.2612
4 O2x O 26.6807 -20.2612
5 O3b O 26.5511 -18.8521
6 C1x C 28.9741 -21.5877
7 C1x C 26.6807 -21.5877
8 C1x C 27.8304 -22.2421
9 C1b C 30.1794 -19.5230
10 C1b C 31.4045 -20.2302
11 X Cl 32.6294 -19.5230
12 C1b C 26.6476 -17.4300
13 C1b C 25.4351 -18.1300
14 X Cl 24.2227 -17.4300
BOND 14
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 2
5 3 6 1
6 4 7 1
7 6 8 1
8 7 8 1
9 3 9 1
10 9 10 1
11 10 11 1
12 2 12 1
13 12 13 1
14 13 14 1
|
|---|
