KEGG   DRUG: Indapamide
Entry
D00345                      Drug                                   
Name
Indapamide (JP18/USP);
Lozol (TN);
Natrix (TN)
Product
  Generic
Formula
C16H16ClN3O3S
Exact mass
365.0601
Mol weight
365.8345
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG02992  Thiazide related diuretic
 DG01690  Sulfonamide diuretic
  DG02992  Thiazide related diuretic
Remark
Therapeutic category: 2149
ATC code: C03BA11
Chemical structure group: DG00269
Product (DG00269): D00345<JP/US>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Sulfonamide derivative
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
    C03BA Sulfonamides, plain
     C03BA11 Indapamide
      D00345  Indapamide (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Indapamide
    D00345  Indapamide (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00345  Indapamide (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG02992  Thiazide related diuretic
    DG00269  Indapamide
     D00345  Indapamide
  DG01690  Sulfonamide diuretic
   DG02992  Thiazide related diuretic
    DG00269  Indapamide
     D00345  Indapamide
Drug classes [BR:br08332]
 Cardiovascular agent
  DG02992  Thiazide related diuretic
   D00345  Indapamide
  DG03231  Antihypertensive
   D00345  Indapamide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 (TSC)
     D00345  Indapamide (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00345  Indapamide
  D00345  Indapamide tablets
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG02992  Thiazide related diuretic
    DG00269  Indapamide
  DG01690  Sulfonamide diuretic
   DG02992  Thiazide related diuretic
    DG00269  Indapamide
Other DBs
CAS: 26807-65-8
PubChem: 7847411
ChEBI: 5893
LigandBox: D00345
NIKKAJI: J10.425F
KCF data

ATOM        24
            1   C8x C    16.4080  -16.4924
            2   C8x C    16.4080  -17.8843
            3   C8x C    17.6134  -18.5803
            4   C8x C    18.8190  -17.8843
            5   C8y C    18.8190  -16.4924
            6   C8y C    17.6134  -15.7964
            7   N1y N    20.0245  -15.7964
            8   C1y C    19.5262  -14.4348
            9   C1x C    18.0723  -14.4284
            10  N1b N    21.2300  -16.4924
            11  C5a C    22.4355  -15.7964
            12  C1a C    20.3390  -13.2774
            13  C8y C    23.6841  -16.5171
            14  O5a O    22.4361  -14.4204
            15  C8x C    23.6842  -17.9198
            16  C8x C    24.8967  -18.6197
            17  C8y C    26.1091  -17.9196
            18  C8y C    26.1090  -16.5169
            19  C8x C    24.8965  -15.8170
            20  S4a S    27.3208  -15.8172
            21  X   Cl   27.3224  -18.6200
            22  N1a N    28.5332  -15.1172
            23  O3c O    26.6169  -14.5979
            24  O3c O    28.0167  -17.0226
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9   6 1
            11   10  11 1
            12    7  10 1
            13    8  12 1
            14   11  13 1
            15   11  14 2
            16   13  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   13  19 1
            22   18  20 1
            23   17  21 1
            24   20  22 1
            25   20  23 2
            26   20  24 2

» Japanese version   » Back

DBGET integrated database retrieval system