 | | DRUG: Lamotrigine | |
| Entry |
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| Name |
Lamotrigine (JAN/USP/INN);
Lamictal (TN) |
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| Product |
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| Generic |
LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (Actavis Pharma), LAMOTRIGINE (Advagen Pharma Limited), LAMOTRIGINE (Advanced Rx Pharmacy of Tennessee), LAMOTRIGINE (Ajanta Pharma USA), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Amring Pharmaceuticals), LAMOTRIGINE (Ascend Laboratories), LAMOTRIGINE (Asclemed USA), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (AvKARE), LAMOTRIGINE (AvKARE), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Camber Pharmaceuticals), LAMOTRIGINE (Cardinal Health 107), LAMOTRIGINE (Cardinal Health 107), LAMOTRIGINE (Cipla USA), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (DirectRX), LAMOTRIGINE (Dr. Reddy's Laboratories), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Glenmark Pharmaceuticals), LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Major Pharmaceuticals), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (Northstar Rx LLC.), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (OWP Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (Par Pharmaceutical), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaeuticals), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Quallent Pharmaceuticals Health LLC), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (Rising Pharma Holdings), LAMOTRIGINE (ST. MARY'S MEDICAL PARK PHARMACY), LAMOTRIGINE (ScieGen Pharmaceuticals), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Unichem Pharmaceuticals (USA)), LAMOTRIGINE (Zydus Lifesciences Limited), LAMOTRIGINE (Zydus Lifesciences Limited), LAMOTRIGINE (Zydus Pharmaceuticals USA), LAMOTRIGINE (Zydus Pharmaceuticals USA), LAMOTRIGINE ER (Direct_Rx), LAMOTRIGINE EXTENDED RELEASE (Par Pharmaceutical), SUBVENITE (OWP Pharmaceuticals) |
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| Formula |
C9H7Cl2N5
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| Exact mass |
255.0079
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| Mol weight |
256.0914
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| Structure |
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| Class |
Neuropsychiatric agent
DG03199 Antiepileptic agent
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03182 UGT1A4 substrate
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| Remark |
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| Efficacy |
Anti-bipolar disorder, Anticonvulsant, Antiepileptic |
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| Disease |
Lennox-Gastaut syndrome [DS: H01813] Bipolar disorder [DS: H01653] |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: UGT1A4 [HSA: 54657]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX09 Lamotrigine
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
Anticonvulsants, Other
Lamotrigine
D00354 Lamotrigine (JAN/USP/INN)
Bipolar Agents
Mood Stabilizers
Lamotrigine
D00354 Lamotrigine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D00354 Lamotrigine (JAN/USP/INN)
117 Psychotropics
1179 Others
D00354 Lamotrigine (JAN/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D00354 Lamotrigine
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03182 UGT1A4 substrate
D00354 Lamotrigine
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D00354 Lamotrigine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN2A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN3A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN4A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN5A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN8A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN9A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN10A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN11A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00354
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00354
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| Other DBs |
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| KCF data |
ATOM 16
1 C8y C 21.7344 -17.9428
2 C8y C 20.5227 -17.2321
3 C8y C 21.7285 -19.3408
4 N5x N 22.9459 -17.2378
5 C8y C 20.5286 -15.8341
6 C8x C 19.3053 -17.9311
7 N5x N 22.9343 -20.0398
8 N1a N 20.5111 -20.0281
9 N5x N 24.1576 -17.9485
10 C8y C 19.3169 -15.1350
11 X Cl 21.7461 -15.1467
12 C8x C 18.0995 -17.2262
13 C8y C 24.1517 -19.3465
14 C8x C 18.0995 -15.8281
15 X Cl 19.3228 -13.7313
16 N1a N 25.3633 -20.0513
BOND 17
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 2
13 10 14 2
14 10 15 1
15 13 16 1
16 9 13 1
17 12 14 1
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