 | | DRUG: Lovastatin | |
| Entry |
|
|---|
| Name |
Lovastatin (USP/INN);
MK-803;
ML-530B;
Mevacor (TN) |
|---|
| Product |
|
|---|
| Generic |
LOVASTATIN (A-S Medication Solutions), LOVASTATIN (A-S Medication Solutions), LOVASTATIN (A-S Medication Solutions), LOVASTATIN (A-S Medication Solutions), LOVASTATIN (A-S Medication Solutions), LOVASTATIN (Aphena Pharma Solutions - Tennessee), LOVASTATIN (Aphena Pharma Solutions - Tennessee), LOVASTATIN (Aphena Pharma Solutions - Tennessee), LOVASTATIN (BluePoint Laboratories), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Carlsbad Technology), LOVASTATIN (Denton Pharma), LOVASTATIN (Direct Rx), LOVASTATIN (Direct_Rx), LOVASTATIN (Direct_Rx), LOVASTATIN (Golden State Medical Supply), LOVASTATIN (Legacy Pharmaceutical Packaging), LOVASTATIN (Lupin Pharmaceuticals), LOVASTATIN (NCS HealthCare of KY), LOVASTATIN (Northwind Pharmaceuticals), LOVASTATIN (Northwind Pharmaceuticals), LOVASTATIN (Northwind Pharmaceuticals), LOVASTATIN (Northwind Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (RPK Pharmaceuticals), LOVASTATIN (RPK Pharmaceuticals), LOVASTATIN (RPK Pharmaceuticals), LOVASTATIN (RPK Pharmaceuticals), LOVASTATIN (Teva Pharmaceuticals USA) |
|---|
| Formula |
C24H36O5
|
|---|
| Exact mass |
404.2563
|
|---|
| Mol weight |
404.5396
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Source |
Monascus ruber [TAX: 89489], Aspergillus terreus [TAX: 33178]
|
|---|
| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
|---|
| Disease |
|
|---|
| Comment |
Active form of prodrug: Lovastatin acid [CPD: C21130]
|
|---|
| Target |
|
|---|
| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Other map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA02 Lovastatin
D00359 Lovastatin (USP/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Lovastatin
D00359 Lovastatin (USP/INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
D00359 Lovastatin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00359 Lovastatin
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D00359 Lovastatin
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D00359 Lovastatin (USP/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00359
Prodrugs [br08324.html]
D00359
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 29
1 C1y C 26.2681 -21.4649
2 C1y C 25.0617 -20.7655
3 C2y C 26.2624 -22.8577
4 C1y C 27.4745 -20.7713
5 O7a O 25.0617 -19.3726
6 C1x C 23.8497 -21.4649
7 C2x C 27.4628 -23.5627
8 C2x C 25.0617 -23.5570
9 C1b C 27.4803 -19.3785
10 C1y C 28.6808 -21.4766
11 C7a C 23.8555 -18.6733
12 C1y C 23.8497 -22.8577
13 C2x C 28.6750 -22.8694
14 C1c C 22.6491 -19.3726
15 O6a O 23.8613 -17.2805
16 C1a C 22.6433 -23.5570
17 C1b C 21.4427 -18.6733
18 C1a C 22.6491 -20.7655
19 C1a C 20.2364 -19.3669
20 C1a C 29.8734 -20.7959
21 C1b C 28.7139 -18.6619
22 C1y C 28.7173 -17.2654
23 O7x O 29.9266 -16.5712
24 C7x C 29.9300 -15.1747
25 C1x C 28.7223 -14.4735
26 C1y C 27.5132 -15.1677
27 C1x C 27.5097 -16.5641
28 O6a O 31.1392 -14.4805
29 O1a O 26.2978 -14.4619
BOND 31
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1 #Down
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 1 #Up
9 4 10 1
10 5 11 1
11 6 12 1
12 7 13 2
13 11 14 1
14 11 15 2
15 12 16 1 #Down
16 14 17 1
17 14 18 1 #Up
18 17 19 1
19 8 12 1
20 10 13 1
21 10 20 1 #Up
22 9 21 1
23 22 21 1 #Down
24 22 23 1
25 23 24 1
26 24 25 1
27 25 26 1
28 26 27 1
29 22 27 1
30 24 28 2
31 26 29 1 #Up
|
|---|
|
» Japanese version » Back
|
|