KEGG DRUG: Loratadine

DRUG: Loratadine

Entry

D00364                      Drug

Name

Loratadine (JAN/USP/INN);
Claritin (TN)

Formula

C22H23ClN2O2

Exact mass

382.1448

Mol weight

382.8832

Structure

Simcomp

Class

Anti-allergic agent
DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Dermatological agent
DG03243  Atopic dermatitis agent
Metabolizing enzyme substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Therapeutic category:

4490

ATC code:

R06AX13

Product:

D00364<JP>

Efficacy

Antiallergic, H1 receptor antagonist

Target

HRH1 [HSA:3269] [KO:K04149]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04750

Inflammatory mediator regulation of TRP channels

Metabolism

Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]

Interaction

Structure map

map07212

Histamine H1 receptor antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX13 Loratadine
      D00364  Loratadine (JAN/USP/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D00364  Loratadine (JAN/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
  Inorganic and organic chemicals
   Loratadine
    D00364  Loratadine (JAN/USP/INN)
Drug groups [BR:br08330]
Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    D00364  Loratadine
Dermatological agent
  DG03243  Atopic dermatitis agent
   D00364  Loratadine
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D00364  Loratadine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00364  Loratadine
Drug classes [BR:br08332]
Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D00364  Loratadine
Dermatological agent
  DG03243  Atopic dermatitis agent
   D00364  Loratadine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00364  Loratadine (JAN/USP/INN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00364
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00364
Rx-to-OTC switch list in the USA [br08315.html]
D00364
Rx-to-OTC switch list in Japan [br08314.html]
D00364

Other DBs

CAS:	79794-75-5

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        27
            1   C1x C    14.9552  -13.2773
            2   C8y C    14.1108  -12.1647
            3   C8y C    14.4469  -10.8042
            4   C2y C    15.7114  -10.2245
            5   C1x C    16.3648  -13.3026
            6   C8y C    16.9683  -10.8485
            7   C8y C    17.2556  -12.2210
            8   C8x C    13.4370   -9.8331
            9   C8x C    12.0914  -10.2223
            10  C8y C    11.7553  -11.5828
            11  C8x C    12.7651  -12.5536
            12  C8x C    18.5904  -12.6593
            13  C8x C    19.6375  -11.7223
            14  C8x C    19.3504  -10.3498
            15  N5x N    18.0153   -9.9115
            16  C2y C    15.6631   -8.8458
            17  X   Cl   10.4237  -11.9675
            18  C1x C    16.8756   -8.1458
            19  C1x C    16.8756   -6.7458
            20  N1y N    15.6631   -6.0458
            21  C1x C    14.4507   -6.7458
            22  C1x C    14.4507   -8.1458
            23  C7a C    15.6628   -4.6201
            24  O6a O    14.4631   -3.9277
            25  O7a O    16.8880   -3.9123
            26  C1b C    18.0903   -4.6062
            27  C1a C    19.2739   -3.9225
BOND        30
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   10  17 1
            20   16  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   16  22 1
            26   20  23 1
            27   23  24 2
            28   23  25 1
            29   25  26 1
            30   26  27 1

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