KEGG   DRUG: Lorazepam
Entry
D00365                      Drug                                   
Name
Lorazepam (JP18/USP/INN);
Ativan (TN)
Product
ATIVAN (Bausch Health US LLC), ATIVAN (Hikma Pharmaceuticals USA), LORAZEPAM (Civica), LORAZEPAM (Hikma Pharmaceuticals USA), LORAZEPAM (Hikma Pharmaceuticals USA), LORAZEPAM (Hikma Pharmaceuticals USA), LORAZEPAM (REMEDYREPACK), LOREEV XR (Almatica Pharma LLC)
  Generic
LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (Akorn), LORAZEPAM (American Health Packaging), LORAZEPAM (Amneal Pharmaceuticals LLC), LORAZEPAM (Amneal Pharmaceuticals LLC), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Asclemed USA), LORAZEPAM (Aurolife Pharma LLC), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Cardinal Health 107), LORAZEPAM (Chartwell RX), LORAZEPAM (Clinical Solutions Wholesale), LORAZEPAM (DIRECT RX), LORAZEPAM (DirectRX), LORAZEPAM (DirectRx), LORAZEPAM (Direct_Rx), LORAZEPAM (Hikma Pharmaceuticals USA), LORAZEPAM (Hospira), LORAZEPAM (International Medication Systems), LORAZEPAM (Leading Pharma), LORAZEPAM (Major Pharmaceuticals), LORAZEPAM (Medsource Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PharmPak), LORAZEPAM (Pharmaceutical Associates), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Quality Care Products), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (RPK Pharmaceuticals), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (SUN PHARMACEUTICAL INDUSTRIES), LORAZEPAM (St. Mary's Medical Park Pharmacy), LORAZEPAM (Teva Pharmaceuticals USA)
Formula
C15H10Cl2N2O2
Exact mass
320.0119
Mol weight
321.1581
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
 DG03199  Antiepileptic agent
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03190  UGT2B7 substrate
  DG03187  UGT2B15 substrate
Remark
Therapeutic category: 1124 1139
ATC code: N05BA06
Product: D00365<JP/US>
Efficacy
Antianxiety, Anticonvulsant, Minor tranquilizer
Comment
Benzodiazepine derivative
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B15 [HSA:7366]
Interaction
Structure map
map07030  Anxiolytics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA06 Lorazepam
      D00365  Lorazepam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Benzodiazepines
    Lorazepam
     D00365  Lorazepam (JP18/USP/INN)
 Anxiolytics
  Benzodiazepines
   Lorazepam
    D00365  Lorazepam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00365  Lorazepam (JP18/USP/INN)
   113  Antiepileptics
    1139  Others
     D00365  Lorazepam (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   D00365  Lorazepam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D00365  Lorazepam
  DG03199  Antiepileptic agent
   D00365  Lorazepam
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03190  UGT2B7 substrate
    D00365  Lorazepam
   DG03187  UGT2B15 substrate
    D00365  Lorazepam
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00365  Lorazepam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00365  Lorazepam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00365  Lorazepam
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00365
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Cabinet order Article 3 (78 substances)
  D00365
Other DBs
CAS: 846-49-1
PubChem: 7847431
ChEBI: 6539
LigandBox: D00365
NIKKAJI: J3.337E
KCF data

ATOM        21
            1   C2y C    19.5808  -11.8131
            2   C8y C    18.7361  -10.7001
            3   C8y C    19.0723   -9.3392
            4   N1x N    20.3372   -8.7593
            5   N2x N    20.9909  -11.8384
            6   C5x C    21.5946   -9.3835
            7   C1y C    21.8820  -10.7564
            8   C8x C    18.0621   -8.3678
            9   C8x C    16.7160   -8.7571
            10  C8y C    16.3798  -10.1180
            11  C8x C    17.3900  -11.0891
            12  O1a O    23.2172  -11.1948
            13  O5x O    22.6419   -8.4462
            14  X   Cl   15.0268  -10.5091
            15  C8y C    18.8591  -13.0128
            16  C8x C    17.4591  -13.0128
            17  C8x C    16.7591  -14.2252
            18  C8x C    17.4591  -15.4377
            19  C8x C    18.8591  -15.4377
            20  C8y C    19.5591  -14.2252
            21  X   Cl   20.9299  -14.2249
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14    6  13 2
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23   20  21 1

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