| Entry |
|
|---|
| Name |
Thioridazine (USP/INN);
Mellaril-S (TN) |
|---|
| Formula |
C21H26N2S2
|
|---|
| Exact mass |
370.1537
|
|---|
| Mol weight |
370.5745
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
|
|---|
| Remark |
| Product (DG00882): | D00798<US> |
|
|---|
| Efficacy |
Antipsychotic, Sedative-hypnotic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AC Phenothiazines with piperidine structure
N05AC02 Thioridazine
D00373 Thioridazine (USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00882 Thioridazine
D00373 Thioridazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00882 Thioridazine
D00373 Thioridazine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00373 Thioridazine (USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00882 Thioridazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00882 Thioridazine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 25
1 N1y N 23.3391 -17.9395
2 C8y C 22.1103 -18.6357
3 C8y C 24.5503 -18.6591
4 C1b C 23.3391 -16.5293
5 C8y C 22.1103 -20.0340
6 C8x C 20.8934 -17.9395
7 C8y C 24.5503 -20.0165
8 C8x C 25.7612 -17.9570
9 C1b C 24.5503 -15.8332
10 S2x S 23.3391 -20.7304
11 C8x C 20.8934 -20.7304
12 C8x C 19.6880 -18.6591
13 C8x C 25.7612 -20.7127
14 C8y C 26.9900 -18.6708
15 C1y C 24.5503 -14.4172
16 C8x C 19.6880 -20.0165
17 C8x C 26.9900 -19.9931
18 N1y N 25.7789 -13.6976
19 C1x C 23.3391 -13.7151
20 C1x C 25.7612 -12.2934
21 C1a C 26.9958 -14.3821
22 C1x C 23.3391 -12.3168
23 C1x C 24.5503 -11.6147
24 S2a S 28.2171 -17.9641
25 C1a C 29.4345 -18.6686
BOND 28
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 1
13 8 14 2
14 9 15 1
15 11 16 2
16 13 17 2
17 15 18 1
18 15 19 1
19 18 20 1
20 18 21 1
21 19 22 1
22 20 23 1
23 7 10 1
24 12 16 1
25 14 17 1
26 22 23 1
27 14 24 1
28 24 25 1
|
|---|
