| Entry |
|
|---|
| Name |
Mephenytoin (USP/INN);
Mesantoin (TN) |
|---|
| Formula |
C12H14N2O2
|
|---|
| Exact mass |
218.1055
|
|---|
| Mol weight |
218.2518
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02031 Hydantoin antiepileptic
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Anticonvulsant |
|---|
| Comment |
Hydantoin derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AB Hydantoin derivatives
N03AB04 Mephenytoin
D00375 Mephenytoin (USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02031 Hydantoin antiepileptic
D00375 Mephenytoin
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
D00375 Mephenytoin
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00375 Mephenytoin (USP/INN)
SCN2A
D00375 Mephenytoin (USP/INN)
SCN3A
D00375 Mephenytoin (USP/INN)
SCN4A
D00375 Mephenytoin (USP/INN)
SCN5A
D00375 Mephenytoin (USP/INN)
SCN8A
D00375 Mephenytoin (USP/INN)
SCN9A
D00375 Mephenytoin (USP/INN)
SCN10A
D00375 Mephenytoin (USP/INN)
SCN11A
D00375 Mephenytoin (USP/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00375
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 16
1 C1z C 20.8941 -17.2706
2 C5x C 19.4767 -17.2762
3 N1x N 21.3729 -15.9550
4 N1y N 19.1015 -15.9329
5 O5x O 18.6308 -18.4135
6 C5x C 20.2356 -15.1090
7 C1a C 17.7859 -15.4541
8 O5x O 20.2300 -13.6917
9 C8y C 22.2941 -17.2706
10 C8x C 22.9937 -18.4823
11 C8x C 24.3937 -18.4824
12 C8x C 25.0937 -17.2699
13 C8x C 24.3941 -16.0582
14 C8x C 22.9941 -16.0581
15 C1b C 20.8941 -18.6706
16 C1a C 19.6477 -19.3902
BOND 17
1 1 2 1
2 1 3 1
3 2 4 1
4 2 5 2
5 3 6 1
6 4 7 1
7 6 8 2
8 4 6 1
9 1 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 9 14 1
16 1 15 1
17 15 16 1
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|---|
