KEGG   DRUG: Tolbutamide
Entry
D00380                      Drug                                   
Name
Tolbutamide (JP18/USP/INN);
Orinase (TN)
Formula
C12H18N2O3S
Exact mass
270.1038
Mol weight
270.3479
Structure
Simcomp
Class
Antidiabetic agent
 DG01508  Sulfonylurea receptor agonist
  DG01734  Sulfonylurea
 DG02044  Hypoglycemic agent
  DG01734  Sulfonylurea
Remark
Same as: C07148
ATC code: A10BB03 V04CA01
Chemical structure group: DG00115
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
  Disease
Non-insulin-dependent diabetes mellitus, type II [DS:H00409]
Comment
Sulfonylurea
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Interaction
Structure map
map07018  Sulfonamide derivatives - hypoglycemic agents
map07051  Antidiabetics
map07055  Sulfonamide derivatives - overview
map07232  Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB03 Tolbutamide
      D00380  Tolbutamide (JP18/USP/INN)
 V VARIOUS
  V04 DIAGNOSTIC AGENTS
   V04C OTHER DIAGNOSTIC AGENTS
    V04CA Tests for diabetes
     V04CA01 Tolbutamide
      D00380  Tolbutamide (JP18/USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Sulfonylureas
    Tolbutamide
     D00380  Tolbutamide (JP18/USP/INN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01508  Sulfonylurea receptor agonist
   DG01734  Sulfonylurea
    DG00115  Tolbutamide
     D00380  Tolbutamide
  DG02044  Hypoglycemic agent
   DG01734  Sulfonylurea
    DG00115  Tolbutamide
     D00380  Tolbutamide
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D00380  Tolbutamide (JP18/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00380  Tolbutamide
  D00380  Tolbutamide tablets
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01508  Sulfonylurea receptor agonist
   DG01734  Sulfonylurea
    DG00115  Tolbutamide
  DG02044  Hypoglycemic agent
   DG01734  Sulfonylurea
    DG00115  Tolbutamide
Other DBs
CAS: 64-77-7
PubChem: 7847446
ChEBI: 27999
LigandBox: D00380
NIKKAJI: J1.406K
KCF data

ATOM        18
            1   C8y C    33.3200  -19.6700
            2   S4a S    34.4400  -18.9700
            3   C8x C    32.0600  -19.0400
            4   C8x C    33.3200  -21.0700
            5   N1b N    35.9800  -19.7400
            6   O3c O    35.2800  -17.7800
            7   O3c O    33.4600  -17.7100
            8   C8x C    30.8700  -19.6700
            9   C8x C    32.1300  -21.7700
            10  C5a C    37.1000  -19.0400
            11  C8y C    30.8700  -21.0700
            12  N1b N    38.3600  -19.6700
            13  O5a O    37.1000  -17.6400
            14  C1a C    29.6800  -21.7700
            15  C1b C    39.4800  -18.9700
            16  C1b C    40.6700  -19.6000
            17  C1b C    41.7900  -18.9000
            18  C1a C    42.9100  -19.5300
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     2   7 2
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    8  11 1
            11   10  12 1
            12   10  13 2
            13   11  14 1
            14   12  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18    9  11 2

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