KEGG   DRUG: Tolnaftate
Entry
D00381                      Drug                                   
Name
Tolnaftate (JP18/USP/INN);
Separin (TN);
Tinactin (TN)
Formula
C19H17NOS
Exact mass
307.1031
Mol weight
307.4094
Structure
Simcomp
Remark
Therapeutic category: 2659
ATC code: D01AE18
Product: D00381<JP>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Thiocarbamate
Target
squalene epoxidase [KO:K00511]
  Pathway
ko00100  Steroid biosynthesis
Structure map
map07026  Antifungal agents
map07114  Naphthalene family
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AE Other antifungals for topical use
     D01AE18 Tolnaftate
      D00381  Tolnaftate (JP18/USP/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   265  Antiparasitic dermatosis agents
    2659  Others
     D00381  Tolnaftate (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  58 Ringworm drugs
   D00381  Tolnaftate (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Tolnaftate
    D00381  Tolnaftate (JP18/USP/INN)
Antimicrobials [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Other ergosterol biosynthesis inhibitor
    D00381  Tolnaftate (JP18/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00381  Tolnaftate
  D00381  Tolnaftate solution
Other DBs
CAS: 2398-96-1
PubChem: 7847447
ChEBI: 9620
LigandBox: D00381
NIKKAJI: J4.423G
KCF data

ATOM        22
            1   C8y C    29.1650  -16.5497
            2   C8y C    29.1650  -17.9549
            3   C8x C    27.9463  -15.8499
            4   C8x C    30.3837  -15.8499
            5   C8x C    27.9522  -18.6487
            6   C8x C    30.3779  -18.6546
            7   C8x C    26.7393  -16.5497
            8   C8x C    31.5966  -16.5497
            9   C8y C    26.7452  -17.9489
            10  C8x C    31.5907  -17.9606
            11  O2a O    25.5324  -18.6487
            12  C2c C    24.3138  -17.9549
            13  N1c N    23.1068  -18.6487
            14  S0  S    24.3138  -16.5554
            15  C8y C    21.8938  -17.9549
            16  C1a C    23.1068  -20.0481
            17  C8x C    20.6868  -18.6546
            18  C8x C    21.8997  -16.5612
            19  C8y C    19.4740  -17.9549
            20  C8x C    20.6927  -15.8499
            21  C8x C    19.4740  -16.5554
            22  C1a C    18.2613  -18.6546
BOND        24
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 2
            10    9  11 1
            11   11  12 1
            12   12  13 1
            13   12  14 2
            14   13  15 1
            15   13  16 1
            16   15  17 2
            17   15  18 1
            18   17  19 1
            19   18  20 2
            20   19  21 2
            21   19  22 1
            22    7   9 2
            23    8  10 1
            24   20  21 1

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   KEGG BRITE (6)   
Pathway (2)   
   KEGG PATHWAY (2)   
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Chemical substance (4)   
   PubChem (1)   
   ChEBI (1)   
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   NIKKAJI (1)   
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