| Entry |
|
|---|
| Name |
Metyrapone (JP18/USP/INN);
Metopirone (TN) |
|---|
| Product |
|
|---|
| Formula |
C14H14N2O
|
|---|
| Exact mass |
226.1106
|
|---|
| Mol weight |
226.2738
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Remark |
| Product (DG01166): | D00410<JP/US> |
|
|---|
| Efficacy |
Diagnostic aid (pituitary function determination) |
|---|
| Comment |
Corticosteroid synthesis inhibitor
For testing hypothalamic-pituitary ACTH function
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Network |
| nt06310 | CRH-ACTH-cortisol signaling |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
V VARIOUS
V04 DIAGNOSTIC AGENTS
V04C OTHER DIAGNOSTIC AGENTS
V04CD Tests for pituitary function
V04CD01 Metyrapone
D00410 Metyrapone (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
249 Miscellaneous
2499 Others
D00410 Metyrapone (JP18/USP/INN)
7 Agents not mainly for therapeutic purpose
72 Intracorporeal diagnostic agents
722 Various function testing reagents
7223 Diagnostic reagents for endocrine function
D00410 Metyrapone (JP18/USP/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Cytochrome P450
CYP11B1
D00410 Metyrapone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00410 Metyrapone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 17
1 C8x C 20.8616 -15.2674
2 N5x N 20.8616 -16.6682
3 C8x C 22.0747 -17.3686
4 C8y C 23.2878 -16.6682
5 C8x C 23.2878 -15.2674
6 C8x C 22.0747 -14.5670
7 C5a C 24.5196 -17.3796
8 C1d C 25.7255 -16.6835
9 C8y C 26.9085 -17.3667
10 O5a O 24.5193 -18.7693
11 C8x C 26.9084 -18.7692
12 C8x C 28.1214 -19.4697
13 C8x C 29.3346 -18.7694
14 N5x N 29.3347 -17.3669
15 C8x C 28.1216 -16.6664
16 C1a C 26.7155 -15.6935
17 C1a C 24.7356 -15.6935
BOND 18
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 7 10 2
11 9 11 2
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 9 15 1
17 8 16 1
18 8 17 1
|
|---|
