KEGG   DRUG: Nabumetone
Entry
D00425                      Drug                                   
Name
Nabumetone (JP18/USP/INN);
Relafen (TN)
Product
  Generic
NABUMETONE (A-S Medication Solutions), NABUMETONE (A-S Medication Solutions), NABUMETONE (A-S Medication Solutions), NABUMETONE (Actavis Pharma), NABUMETONE (Advanced Rx Pharmacy of Tennessee), NABUMETONE (Advanced Rx Pharmacy of Tennessee), NABUMETONE (Advanced Rx Pharmacy of Tennessee), NABUMETONE (American Health Packaging), NABUMETONE (Asclemed USA), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Chartwell RX), NABUMETONE (Cipla USA), NABUMETONE (Exelan Pharmaceuticals), NABUMETONE (LGM PHARMA SOLUTIONS), NABUMETONE (Lupin Pharmaceuticals), NABUMETONE (Medsource Pharmaceuticals), NABUMETONE (Medsource Pharmaceuticals), NABUMETONE (Northwind Pharmaceuticals), NABUMETONE (Northwind Pharmaceuticals), NABUMETONE (Northwind Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Quality Care Products), NABUMETONE (Quality Care Products), NABUMETONE (REMEDYREPACK), NABUMETONE (REMEDYREPACK), NABUMETONE (RPK Pharmaceuticals), NABUMETONE (ScieGen Pharmaceuticals), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (Westminster Pharmaceuticals), NABUMETONE (direct rx), NABUMETONE (medsource pharmaceuticals), RELAFEN DS (Carwin Pharmaceutical Associates)
Formula
C15H16O2
Exact mass
228.115
Mol weight
228.2863
Structure
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01922  Selective COX2 inhibitor
Remark
Therapeutic category: 1149
ATC code: M01AX01
Product: D00425<JP/US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Target
PTGS2 (COX2) [HSA:5743] [KO:K11987]
PTGS1 (COX1) [HSA:5742] [KO:K00509]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AX Other antiinflammatory and antirheumatic agents, non-steroids
     M01AX01 Nabumetone
      D00425  Nabumetone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Nabumetone
    D00425  Nabumetone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00425  Nabumetone (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01922  Selective COX2 inhibitor
    D00425  Nabumetone
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00425  Nabumetone
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00425  Nabumetone (JP18/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00425  Nabumetone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00425  Nabumetone
  D00425  Nabumetone tablets
Other DBs
CAS: 42924-53-8
PubChem: 7847491
ChEBI: 7443
PDB-CCD: NBO[PDBj]
LigandBox: D00425
NIKKAJI: J16.442I
KCF data

ATOM        17
            1   C8y C    27.8600  -24.7800
            2   C8y C    27.8600  -26.1800
            3   C8x C    29.0500  -24.0800
            4   C8x C    26.6000  -24.0800
            5   C8x C    26.6000  -26.8800
            6   C8x C    29.0500  -26.8800
            7   C8y C    30.2400  -24.7800
            8   C8x C    25.4100  -24.7800
            9   C8y C    25.4100  -26.1800
            10  C8x C    30.2400  -26.1800
            11  C1b C    31.4300  -24.0800
            12  O2a O    24.2200  -26.8800
            13  C1b C    32.6200  -24.7800
            14  C1a C    22.9600  -26.1800
            15  C5a C    33.8100  -24.0800
            16  C1a C    35.0700  -24.7800
            17  O5a O    33.8100  -22.6800
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   15  17 2
            17    7  10 1
            18    8   9 2

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Ontology (7)   
   KEGG BRITE (7)   
Pathway (2)   
   KEGG PATHWAY (2)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (5)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
All databases (21)   

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