KEGG   DRUG: Risperidone
Entry
D00426                      Drug                                   
Name
Risperidone (JP18/USP/INN);
Risperdal (TN)
Product
PERSERIS (Indivior), RISPERDAL CONSTA (Janssen Pharmaceuticals), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Janssen Pharmaceutical), RISPERIDONE (Janssen Pharmaceuticals), RISPERIDONE (REMEDYREPACK), RYKINDO (Shandong Luye Pharmaceutical), UZEDY (Teva Pharmaceuticals USA)
  Generic
RISPERIDONE (A-S Medication Solutions), RISPERIDONE (A-S Medication Solutions), RISPERIDONE (Ajanta Pharma USA), RISPERIDONE (American Health Packaging), RISPERIDONE (Amneal Pharmaceuticals LLC), RISPERIDONE (Amneal Pharmaceuticals NY LLC), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aurobindo Pharma Limited), RISPERIDONE (AvKARE), RISPERIDONE (AvKARE), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Cardinal Health 107), RISPERIDONE (Chartwell RX), RISPERIDONE (Chartwell RX), RISPERIDONE (Direct_Rx), RISPERIDONE (Hikma Pharmaceuticals USA), RISPERIDONE (Jubilant Cadista Pharmaceuticals), RISPERIDONE (Major Pharmaceuticals), RISPERIDONE (Major Pharmaceuticals), RISPERIDONE (NCS HealthCare of KY), RISPERIDONE (Natco Pharma USA LLC), RISPERIDONE (NuCare Pharmaceuticals), RISPERIDONE (PD-Rx Pharmaceuticals), RISPERIDONE (PD-Rx Pharmaceuticals), RISPERIDONE (Par Pharmaceutical), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Quality Care Products), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (RPK Pharmaceuticals), RISPERIDONE (RPK Pharmaceuticals), RISPERIDONE (Solco Healthcare US), RISPERIDONE (Sun Pharmaceutical Industries), RISPERIDONE (Teva Pharmaceuticals), RISPERIDONE (Torrent Pharmaceuticals Limited), RISPERIDONE (Tris Pharma), RISPERIDONE (Zydus Lifesciences Limited), RISPERIDONE (Zydus Lifesciences Limited), RISPERIDONE (Zydus Pharmaceuticals USA), RISPERIDONE (Zydus Pharmaceuticals USA)
Formula
C23H27FN4O2
Exact mass
410.2118
Mol weight
410.4845
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03005  Serotonin-dopamine antagonist (SDA)
 DG03200  Antipsychotic agent
  DG03064  Atypical antipsychotic
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1179
ATC code: N05AX08
Product: D00426<JP/US>
Efficacy
Antipsychotic, Neuroleptic
  Disease
Schizophrenia [DS:H01649]
Bipolar mania [DS:H01653]
Comment
Serotonin-dopamine antagonists (SDA)
Active form of prodrug: Paliperidone [DR:D05339]
Target
DRD2 [HSA:1813] [KO:K04145]
HTR2A [HSA:3356] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Structure map
map07028  Antipsychotics
map07211  Serotonin receptor agonists/antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX08 Risperidone
      D00426  Risperidone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Risperidone
    D00426  Risperidone (JP18/USP/INN)
 Bipolar Agents
  Bipolar Agents, Other
   Risperidone
    D00426  Risperidone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00426  Risperidone (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    D00426  Risperidone
  DG03005  Serotonin-dopamine antagonist (SDA)
   D00426  Risperidone
  DG03200  Antipsychotic agent
   DG03064  Atypical antipsychotic
    D00426  Risperidone
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D00426  Risperidone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00426  Risperidone
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00426  Risperidone (JP18/USP/INN) <JP/US>
   Serotonin
    HTR2A
     D00426  Risperidone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00426  Risperidone
  D00426  Risperidone tablets
  D00426  Risperidone fine granules
  D00426  Risperidone solution
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00426
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00426
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00426
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00426
Prodrugs [br08324.html]
 D00426
Other DBs
CAS: 106266-06-2
PubChem: 7847492
ChEBI: 8871
PDB-CCD: 8NU[PDBj]
LigandBox: D00426
NIKKAJI: J138.382E
KCF data

ATOM        30
            1   C1y C    22.2076  -18.2560
            2   C1x C    22.2076  -16.8437
            3   C1x C    23.4315  -18.9622
            4   C1x C    23.4315  -16.1376
            5   C1x C    24.6555  -18.2560
            6   N1y N    24.6555  -16.8437
            7   C1b C    25.8795  -16.1847
            8   C1b C    27.0564  -16.8437
            9   C8y C    28.2333  -16.1847
            10  C8y C    29.4572  -16.8437
            11  C8y C    28.2333  -14.7724
            12  N4y N    30.6813  -16.1847
            13  O5x O    29.4572  -18.2560
            14  N5x N    29.4572  -14.0663
            15  C1a C    27.0564  -14.0663
            16  C8y C    30.6813  -14.7253
            17  C1x C    31.9523  -16.8437
            18  C1x C    31.9523  -14.0663
            19  C1x C    33.1292  -16.1847
            20  C1x C    33.1292  -14.7724
            21  C8y C    20.9846  -18.9624
            22  N5x N    19.8537  -18.1619
            23  O2x O    18.7431  -18.9900
            24  C8y C    19.1873  -20.3023
            25  C8y C    20.5727  -20.2852
            26  C8x C    18.4886  -21.5043
            27  C8y C    19.1911  -22.7295
            28  C8x C    20.6034  -22.7337
            29  C8x C    21.3021  -21.5317
            30  X   F    18.4827  -23.9479
BOND        34
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 2
            11   10  12 1
            12   10  13 2
            13   11  14 1
            14   11  15 1
            15   12  16 1
            16   12  17 1
            17   16  18 1
            18   17  19 1
            19   18  20 1
            20    5   6 1
            21   14  16 2
            22   19  20 1
            23    1  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 1
            27   24  25 2
            28   21  25 1
            29   24  26 1
            30   26  27 2
            31   27  28 1
            32   28  29 2
            33   29  25 1
            34   27  30 1

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