 | | DRUG: Omeprazole | |
| Entry |
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| Name |
Omeprazole (JP18/USP/INN);
Prilosec (TN) |
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| Product |
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| Generic |
OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (A-S Medication Solutions), OMEPRAZOLE (Advanced Rx Pharmacy of Tennessee), OMEPRAZOLE (Advanced Rx Pharmacy of Tennessee), OMEPRAZOLE (Advanced Rx Pharmacy of Tennessee), OMEPRAZOLE (Advanced Rx Pharmacy of Tennessee), OMEPRAZOLE (American Health Packaging), OMEPRAZOLE (American Health Packaging), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Aphena Pharma Solutions - Tennessee), OMEPRAZOLE (Apotex Corp), OMEPRAZOLE (Asclemed USA), OMEPRAZOLE (Aurobindo Pharma Limited), OMEPRAZOLE (AvPAK), OMEPRAZOLE (AvPAK), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Bryant Ranch Prepack), OMEPRAZOLE (Camber Pharmaceuticals), OMEPRAZOLE (Cardinal Health 107), OMEPRAZOLE (Cardinal Health 107), OMEPRAZOLE (Chartwell RX), OMEPRAZOLE (DirexctRX), OMEPRAZOLE (Dr. Reddy's Laboratories Limited), OMEPRAZOLE (Dr. Reddy's Laboratories Limited), OMEPRAZOLE (Glenmark Pharmaceuticals), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Golden State Medical Supply), OMEPRAZOLE (Lannett Company), OMEPRAZOLE (Major Pharmaceuticals), OMEPRAZOLE (NCS HealthCare of KY), OMEPRAZOLE (NCS HealthCare of KY), OMEPRAZOLE (NorthStar Rx LLC), OMEPRAZOLE (NorthStar Rx LLC), OMEPRAZOLE (Northwind Pharmaceuticals), OMEPRAZOLE (Northwind Pharmaceuticals), OMEPRAZOLE (Northwind Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCare Pharmaceuticals), OMEPRAZOLE (NuCarePharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (PD-Rx Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Preferred Pharmaceuticals), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (Proficient Rx LP), OMEPRAZOLE (QPharma), OMEPRAZOLE (QPharma), OMEPRAZOLE (QPharma), OMEPRAZOLE (Quality Care Products LLC), OMEPRAZOLE (Quality Care Products), OMEPRAZOLE (Quallent Pharmaceuticals Health LLC), OMEPRAZOLE (Quallent Pharmaceuticals Health LLC), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (REMEDYREPACK), OMEPRAZOLE (RPK Pharmaceuticals), OMEPRAZOLE (RPK Pharmaceuticals), OMEPRAZOLE (RPK Pharmaceuticals), OMEPRAZOLE (Rising Health), OMEPRAZOLE (Sandoz), OMEPRAZOLE (Sandoz), OMEPRAZOLE (Sandoz), OMEPRAZOLE (St. Mary's Medical Park Pharmacy), OMEPRAZOLE (St. Mary's Medical Park Pharmacy), OMEPRAZOLE (Strides Pharma Science Limited), OMEPRAZOLE (Xiromed), OMEPRAZOLE (Zydus Lifesciences Limited), OMEPRAZOLE (Zydus Pharmaceuticals USA), OMEPRAZOLE (medsource pharmaceuticals), OMEPRAZOLE DR (Direct Rx) |
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| Formula |
C17H19N3O3S
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| Exact mass |
345.1147
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| Mol weight |
345.4161
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| Structure |
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| Simcomp |
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| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2329 |
| Product (DG00020): | D00455<JP/US> D05261<JP> D05259<US> |
| Product (mixture): | D10246<US> D11706<US> |
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| Efficacy |
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor |
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| Disease |
Duodenal ulcer [DS: H01634] Gastric ulcer [DS: H01634] Gastroesophageal reflux disease [DS: H01602] Zollinger-Ellison syndrome [DS: H01522] Multiple endocrine adenomas [DS: H01102] |
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| Comment |
Benzimidazole derivative
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]; CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC01 Omeprazole
D00455 Omeprazole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Proton Pump Inhibitors
Omeprazole
D00455 Omeprazole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
232 Peptic ulcer agents
2329 Others
D00455 Omeprazole (JP18/USP/INN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00020 Omeprazole
D00455 Omeprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00020 Omeprazole
D00455 Omeprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00020 Omeprazole
D00455 Omeprazole
Drug classes [BR:br08332]
Gastrointestinal agent
DG01646 Proton pump inhibitor (PPI)
D00455 Omeprazole
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D00455 Omeprazole (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00455 Omeprazole
D00455 Omeprazole enteric-coated tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00455
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00455
Rx-to-OTC switch list in the USA [br08315.html]
D00455
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00020 Omeprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00020 Omeprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00020 Omeprazole
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| Other DBs |
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| KCF data |
ATOM 24
1 C8x C 14.6300 -20.7200
2 C8y C 14.6300 -22.1200
3 C8x C 15.8424 -22.8200
4 C8y C 17.0549 -22.1200
5 C8y C 17.0549 -20.7200
6 C8x C 15.8424 -20.0200
7 N5x N 18.3864 -22.5526
8 C8y C 19.2093 -21.4200
9 N4x N 18.3864 -20.2874
10 S4a S 20.5800 -21.4200
11 O2a O 13.4176 -22.8200
12 C1a C 12.2221 -22.1296
13 C1b C 21.2800 -22.6324
14 O3c O 21.2800 -20.2076
15 C8y C 22.6798 -22.6324
16 C8y C 23.3703 -23.8280
17 C8y C 24.7703 -23.8278
18 C8y C 25.4701 -22.6153
19 C8x C 24.7797 -21.4198
20 N5x N 23.3797 -21.4199
21 C1a C 26.8800 -22.6152
22 O2a O 25.4610 -25.0232
23 C1a C 26.8796 -25.0232
24 C1a C 22.6849 -25.0152
BOND 26
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 5 9 1
11 8 10 1
12 2 11 1
13 11 12 1
14 10 13 1
15 10 14 2
16 13 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 15 20 1
23 18 21 1
24 17 22 1
25 22 23 1
26 16 24 1
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