 | | DRUG: Ondansetron | |
| Entry |
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| Name |
Ondansetron (JAN/USP/INN);
Zofran ODT (TN) |
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| Product |
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| Generic |
ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (Advanced Rx Pharmacy of Tennessee), ONDANSETRON (Advanced Rx Pharmacy of Tennessee), ONDANSETRON (Asclemed USA), ONDANSETRON (Asclemed USA), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON (BluePoint Laboratories), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Chartwell RX), ONDANSETRON (DIRECT RX), ONDANSETRON (Denton Pharma), ONDANSETRON (Denton Pharma), ONDANSETRON (Direct Rx), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Medsource Pharmaceuticals), ONDANSETRON (Medsource Pharmaceuticals), ONDANSETRON (Mylan Pharmaceuticals), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (Pharmasource Meds), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Quality Care Products LLC), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (Redpharm Drug), ONDANSETRON (Rising Pharma Holdings), ONDANSETRON (ST. MARY'S MEDICAL PARK PHARMACY), ONDANSETRON (St Marys Medical Park Pharmacy), ONDANSETRON (St Marys Medical Park Pharmacy), ONDANSETRON (St. Mary's Medical Park Pharmacy) |
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| Formula |
C18H19N3O
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| Exact mass |
293.1528
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| Mol weight |
293.363
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| Structure |
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| Simcomp |
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| Class |
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00060): | D00456<US> D00678<JP/US> |
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| Efficacy |
Anti-emetic, Serotonin 5-HT3 receptor antagonist |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
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| Interaction |
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| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A04 ANTIEMETICS AND ANTINAUSEANTS
A04A ANTIEMETICS AND ANTINAUSEANTS
A04AA Serotonin (5HT3) antagonists
A04AA01 Ondansetron
D00456 Ondansetron (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
Antiemetics
Emetogenic Therapy Adjuncts
Ondansetron
D00456 Ondansetron (JAN/USP/INN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00060 Ondansetron
D00456 Ondansetron
DG01762 Antiemetic
DG00060 Ondansetron
D00456 Ondansetron
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00060 Ondansetron
D00456 Ondansetron
DG01644 CYP2D6 substrate
DG00060 Ondansetron
D00456 Ondansetron
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00060 Ondansetron
D00456 Ondansetron
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D00456 Ondansetron (JAN/USP/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00456
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00060 Ondansetron
DG01762 Antiemetic
DG00060 Ondansetron
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00060 Ondansetron
DG01644 CYP2D6 substrate
DG00060 Ondansetron
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00060 Ondansetron
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| Other DBs |
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| KCF data |
ATOM 22
1 C8y C 33.5159 -17.7325
2 C8y C 34.8490 -18.1807
3 C8y C 33.5217 -16.3295
4 C5x C 32.3109 -18.4368
5 C8y C 35.6698 -17.0396
6 C8x C 35.4254 -19.4557
7 N4y N 34.8607 -15.9044
8 C1x C 32.3109 -15.6367
9 C1y C 31.0941 -17.7325
10 O5x O 32.3166 -19.8341
11 C8x C 37.0613 -17.1794
12 C8x C 36.8167 -19.5896
13 C1a C 35.2972 -14.5771
14 C1x C 31.0941 -16.3295
15 C1b C 29.8831 -18.4368
16 C8x C 37.6318 -18.4544
17 N4y N 28.6780 -17.7325
18 C8y C 28.7203 -16.3253
19 C8x C 27.3348 -18.1219
20 N5x N 27.3985 -15.8508
21 C1a C 29.8791 -15.5437
22 C8x C 26.5473 -16.9625
BOND 25
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 1
9 4 10 2
10 5 11 2
11 6 12 1
12 7 13 1
13 8 14 1
14 9 15 1
15 11 16 1
16 15 17 1
17 17 18 1
18 17 19 1
19 18 20 2
20 18 21 1
21 19 22 2
22 5 7 1
23 9 14 1
24 12 16 2
25 20 22 1
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