| Entry |
|
|---|
| Name |
Quinapril hydrochloride (JP18/USP);
Accupril (TN) |
|---|
| Product |
|
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| Generic |
QUINAPRIL (A-S Medication Solutions), QUINAPRIL (A-S Medication Solutions), QUINAPRIL (American Health Packaging), QUINAPRIL (Aurobindo Pharma Limited), QUINAPRIL (BluePoint Laboratories), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Chartwell RX), QUINAPRIL (Cipla USA), QUINAPRIL (Lupin Pharmaceuticals), QUINAPRIL (Northwind Pharmaceuticals), QUINAPRIL (Proficient Rx LP), QUINAPRIL (Proficient Rx LP), QUINAPRIL (Proficient Rx LP), QUINAPRIL (Proficient Rx LP), QUINAPRIL (Solco Healthcare US) |
|---|
| Formula |
C25H30N2O5. HCl
|
|---|
| Exact mass |
474.1922
|
|---|
| Mol weight |
474.977
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
|
|---|
| Remark |
| Product (DG00338): | D00459<US> |
| Product (mixture): | D10278<US> |
|
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| Efficacy |
Antihypertensive, Angiotensin-converting enzyme inhibitor |
|---|
| Disease |
|
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| Comment |
Active form of prodrug: Quinaprilat [DR: D03773]
|
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| Target |
|
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| Pathway |
|
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| Interaction |
|
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| Structure map |
| map07217 | Renin-angiotensin system inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09A ACE INHIBITORS, PLAIN
C09AA ACE inhibitors, plain
C09AA06 Quinapril
D00459 Quinapril hydrochloride (JP18/USP) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Angiotensin-converting Enzyme (ACE) Inhibitors
Quinapril
D00459 Quinapril hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00338 Quinapril
D00459 Quinapril hydrochloride
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00338 Quinapril
D00459 Quinapril hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01501 Angiotensin-converting enzyme inhibitor
D00459 Quinapril hydrochloride
DG03231 Antihypertensive
D00459 Quinapril hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Peptidyl-dipeptidases
ACE (CD143)
D00459 Quinapril hydrochloride (JP18/USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00459 Quinapril hydrochloride
D00459 Quinapril hydrochloride tablets
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00338 Quinapril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00338 Quinapril
Prodrugs [br08324.html]
DG00338
|
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| Other DBs |
|
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| KCF data |
ATOM 33
1 C1x C 28.2490 -19.8211
2 C8y C 29.4582 -19.1183
3 N1y N 27.0337 -19.1187
4 C8y C 29.4645 -17.7270
5 C8x C 30.6604 -19.8200
6 C1y C 27.0378 -17.7192
7 C1x C 28.2493 -17.0245
8 C8x C 30.6680 -17.0343
9 C8x C 31.8720 -19.1253
10 C8x C 31.8732 -17.7311
11 N1b N 23.4099 -19.8234
12 C1c C 22.1992 -19.1275
13 C7a C 22.1933 -17.7238
14 C1b C 20.9826 -19.8351
15 O7a O 23.4099 -17.0219
16 O6a O 20.9709 -17.0277
17 C1b C 19.7661 -19.1450
18 C1b C 23.4040 -15.6182
19 C8y C 18.5554 -19.8351
20 C1a C 22.1875 -14.9223
21 C8x C 18.5554 -21.2506
22 C8x C 17.3506 -19.1450
23 C8x C 17.3506 -21.9582
24 C8x C 16.1282 -19.8351
25 C8x C 16.1282 -21.2506
26 C1c C 24.6167 -19.1187
27 C5a C 25.8252 -19.8183
28 O5a O 25.8252 -21.2177
29 C1a C 24.6140 -17.7194
30 C6a C 27.0266 -16.3129
31 O6a O 28.2329 -15.6036
32 O6a O 25.8093 -15.6229
33 X Cl 30.5428 -21.2516
BOND 34
1 8 10 2
2 6 7 1
3 9 10 1
4 11 12 1
5 12 13 1 #Up
6 12 14 1
7 13 15 1
8 13 16 2
9 14 17 1
10 15 18 1
11 17 19 1
12 18 20 1
13 19 21 1
14 19 22 2
15 21 23 2
16 22 24 1
17 23 25 1
18 24 25 2
19 1 2 1
20 11 26 1
21 1 3 1
22 26 27 1
23 27 3 1
24 2 4 2
25 27 28 2
26 2 5 1
27 26 29 1 #Up
28 3 6 1
29 6 30 1 #Down
30 4 7 1
31 30 31 1
32 4 8 1
33 30 32 2
34 5 9 2
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