| Entry |
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| Name |
Prednisolone (JP18/USP/INN);
Delta-cortef (TN) |
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| Product |
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| Generic |
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| Formula |
C21H28O5
|
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| Exact mass |
360.1937
|
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| Mol weight |
360.444
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
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| Remark |
| Product (DG00093): | D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP> |
| Product (mixture): | D04251<JP> D04753<JP> |
|
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| Efficacy |
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist |
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| Disease |
Congenital adrenal hyperplasia [DS: H00216] Psoriatic arthritis [DS: H01507] Rheumatoid arthritis [DS: H00630] Juvenile rheumatoid arthritis [DS: H01672] Ankylosing spondylitis [DS: H01674] Systemic lupus erythematosus [DS: H00080] Pemphigus [DS: H01648] Bullous dermatitis herpetiformis [DS: H01362] Erythema multiforme [DS: H01695] Stevens-Johnson syndrome [DS: H01694] Mycosis fungoides [DS: H01463] Psoriasis [DS: H01656] Seborrheic dermatitis [DS: H01652] Allergic rhinitis [DS: H01360] Bronchial asthma [DS: H00079] Contact dermatitis [DS: H01357] Atopic dermatitis [DS: H01358] Optic neuritis [DS: H01717] Pulmonary tuberculosis [DS: H00342] Acquired (autoimmune) hemolytic anemia [DS: H01585] Nephrotic syndrome [DS: H01657] Ulcerative colitis [DS: H01466] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC04 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA01 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA04 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA03 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA02 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB06 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD02 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA04 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB02 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA03 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA02 Prednisolone
D00472 Prednisolone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Prednisolone
D00472 Prednisolone (JP18/USP/INN)
Inflammatory Bowel Disease Agents
Glucocorticoids
Prednisolone
D00472 Prednisolone (JP18/USP/INN)
Ophthalmic Agents
Ophthalmic Anti-inflammatories
Glucocorticoids, Ophthalmic
Prednisolone
D00472 Prednisolone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2456 Prednisolones
D00472 Prednisolone (JP18/USP/INN)
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D00472 Prednisolone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00472 Prednisolone (JP18/USP/INN)
Agents for dental and stomatological use
74 Stomatitis remedies
D00472 Prednisolone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Prednisolone
D00472 Prednisolone (JP18/USP/INN)
Second-class OTC drugs
Inorganic and organic chemicals
Prednisolone
D00472 Prednisolone (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00093 Prednisolone
D00472 Prednisolone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
D00472 Prednisolone
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00472 Prednisolone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00472 Prednisolone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00472 Prednisolone
D00472 Prednisolone tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00472
Topical steroids potency [br08317.html]
Classification in Japan
D00472
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00093 Prednisolone
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| Other DBs |
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| KCF data |
ATOM 26
1 C2x C 5.9500 -12.1800
2 C5x C 5.9500 -13.5800
3 C2x C 7.1624 -14.2800
4 C2y C 8.3749 -13.5800
5 C1z C 8.3749 -12.1800
6 C2x C 7.1624 -11.4800
7 C1x C 9.5873 -14.2800
8 C1x C 10.7997 -13.5800
9 C1y C 10.7997 -12.1800
10 C1y C 9.5873 -11.4800
11 C1y C 12.0122 -11.4800
12 C1z C 12.0122 -10.0800
13 C1x C 10.7997 -9.3800
14 C1y C 9.5873 -10.0800
15 C1x C 14.4370 -11.4800
16 C1x C 14.4370 -10.0800
17 C1z C 13.2246 -9.3800
18 O5x O 4.7376 -14.2800
19 C1a C 8.3749 -10.7800
20 O1a O 8.3769 -9.3812
21 C1a C 12.0122 -8.6800
22 C5a C 13.2246 -7.7700
23 O1a O 14.4370 -8.6800
24 C1b C 14.4411 -7.0677
25 O5a O 12.0162 -7.0723
26 O1a O 15.6386 -7.7592
BOND 29
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 14 20 1 #Up
24 12 21 1 #Up
25 17 22 1 #Up
26 17 23 1 #Down
27 22 24 1
28 22 25 2
29 24 26 1
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