| Entry |
|
|---|
| Name |
Propoxyphene hydrochloride (USAN);
Dextropropoxyphene hydrochloride;
Darvon (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C22H29NO2. HCl
|
|---|
| Exact mass |
375.1965
|
|---|
| Mol weight |
375.9321
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
|
|---|
| Remark |
| Product (DG00818): | D00482<US> |
|
|---|
| Efficacy |
Analgesic, Opioid receptor agonist |
|---|
| Comment |
Diphenylpropylamine derivative
Propoxyphene is called Dextropropoxyphene in INN.
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AC Diphenylpropylamine derivatives
N02AC04 Dextropropoxyphene
D00482 Propoxyphene hydrochloride (USAN) <US>
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00818 Dextropropoxyphene
D00482 Propoxyphene hydrochloride
Analgesic
DG01984 Opioid analgesics
DG00818 Dextropropoxyphene
D00482 Propoxyphene hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D00482 Propoxyphene hydrochloride (USAN) <US>
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00818 Dextropropoxyphene
Analgesic
DG01984 Opioid analgesics
DG00818 Dextropropoxyphene
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 26
1 X Cl 23.9038 -16.2708
2 C8x C 14.7259 -19.2286
3 C8x C 15.4238 -20.4397
4 C8x C 16.8216 -20.4408
5 C8x C 17.5215 -19.2309
6 C8y C 16.8236 -18.0198
7 C8x C 15.4258 -18.0187
8 C8x C 18.9192 -19.2320
9 C8y C 19.6191 -18.0220
10 C1b C 18.9211 -16.8109
11 C1d C 17.5234 -16.8098
12 C8x C 19.6171 -20.4430
13 C8x C 21.0149 -20.4441
14 C8x C 21.7148 -19.2342
15 C8x C 21.0169 -18.0231
16 O7a O 16.8395 -15.6226
17 C7a C 15.4474 -15.6215
18 O6a O 14.7386 -16.8466
19 C1b C 14.7583 -14.4256
20 C1a C 13.3509 -14.4243
21 C1c C 18.2223 -15.5994
22 C1a C 19.6403 -15.5998
23 C1b C 17.5168 -14.3775
24 N1c N 18.2193 -13.1601
25 C1a C 19.6402 -13.1603
26 C1a C 17.5113 -11.9347
BOND 26
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 8 9 1
8 9 10 1
9 11 10 1 #Down
10 11 6 1 #Up
11 8 12 2
12 12 13 1
13 13 14 2
14 14 15 1
15 9 15 2
16 11 16 1
17 16 17 1
18 17 18 2
19 17 19 1
20 19 20 1
21 11 21 1
22 21 22 1 #Up
23 21 23 1
24 23 24 1
25 24 25 1
26 24 26 1
|
|---|
