 | | DRUG: Isosorbide dinitrate | |
| Entry |
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| Name |
Isosorbide dinitrate (JP18/USP/INN);
Dilatrate-sr (TN);
Isordil (TN) |
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| Product |
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| Generic |
ISOSORBIDE (BluePoint Laboratories), ISOSORBIDE DINITRATE (Advagen Pharma), ISOSORBIDE DINITRATE (American Health Packaging), ISOSORBIDE DINITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE DINITRATE (AvKARE), ISOSORBIDE DINITRATE (AvPAK), ISOSORBIDE DINITRATE (BluePoint Laboratories), ISOSORBIDE DINITRATE (Bryant Ranch Prepack), ISOSORBIDE DINITRATE (Cardinal Health 107), ISOSORBIDE DINITRATE (Golden State Medical Supply), ISOSORBIDE DINITRATE (Hikma Pharmaceuticals USA), ISOSORBIDE DINITRATE (Major Pharmaceuticals), ISOSORBIDE DINITRATE (McKesson Corporation dba SKY Packaging), ISOSORBIDE DINITRATE (NCS HealthCare of KY), ISOSORBIDE DINITRATE (Northstar Rx LLC), ISOSORBIDE DINITRATE (Par Pharmaceutical), ISOSORBIDE DINITRATE (Par Pharmaceutical), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (Sandoz), ISOSORBIDE DINITRATE (Zydus Lifesciences Limited), ISOSORBIDE DINITRATE (Zydus Pharmaceuticals (USA)) |
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| Formula |
C6H8N2O8
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| Exact mass |
236.0281
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| Mol weight |
236.1363
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01657 Nitrovasodilator
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| Remark |
| Therapeutic category: | 2171 |
| Product (DG01270): | D00516<JP/US> D00630<JP/US> |
| Product (mixture): | D10209<US> |
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| Efficacy |
Vasodilator (coronary) |
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| Disease |
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| Comment |
Organic nitrate
Osmotic diuretics
Nitric oxide donor
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01D VASODILATORS USED IN CARDIAC DISEASES
C01DA Organic nitrates
C01DA08 Isosorbide dinitrate
D00516 Isosorbide dinitrate (JP18/USP/INN) <JP/US>
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AE Muscle relaxants
C05AE02 Isosorbide dinitrate
D00516 Isosorbide dinitrate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Vasodilators
Vasodilators, Direct-acting Arterial/Venous
Isosorbide Dinitrate
D00516 Isosorbide dinitrate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
217 Vasodilators
2171 Coronary dilators
D00516 Isosorbide dinitrate (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01657 Nitrovasodilator
DG01270 Isosorbide nitrate
D00516 Isosorbide dinitrate
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00516 Isosorbide dinitrate
D00516 Isosorbide dinitrate tablets
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00516
Drug groups [BR:br08330]
Cardiovascular agent
DG01657 Nitrovasodilator
DG01270 Isosorbide nitrate
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| Other DBs |
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| KCF data |
ATOM 16
1 C1y C 20.6734 -17.3108
2 C1y C 20.6734 -15.9089
3 C1y C 19.3401 -15.4757
4 C1x C 18.5160 -16.6098
5 O2x O 19.3401 -17.7440
6 C1y C 22.0067 -17.7440
7 C1x C 22.8307 -16.6098
8 O2x O 22.0067 -15.4757
9 O2a O 22.4361 -19.0654
10 O2a O 18.9107 -14.1543
11 N2b N 17.4407 -14.1543 #+
12 O3a O 16.7319 -12.9265 #-
13 O3a O 16.7441 -15.3605
14 N2b N 23.8361 -19.0654 #+
15 O3a O 24.5334 -20.2728 #-
16 O3a O 24.5550 -17.7490
BOND 17
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 1 5 1
6 1 6 1
7 6 7 1
8 7 8 1
9 2 8 1
10 6 9 1 #Up
11 3 10 1 #Down
12 10 11 1
13 11 12 1
14 11 13 2
15 9 14 1
16 14 15 1
17 14 16 2
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