| Entry |
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| Name |
Dimenhydrinate (JP18/USP/INN);
Dramamine (TN) |
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| Product |
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| Generic |
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| Formula |
C17H21NO. C7H7ClN4O2
|
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| Exact mass |
469.1881
|
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| Mol weight |
469.9638
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| Structure |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Respiratory system agent
DG01616 Xanthine derivative
|
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| Remark |
| Therapeutic category: | 1331 |
| Product (DG00390): | D00300<JP> D00669<JP/US> D03360<JP> D00520<JP/US> |
|
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| Efficacy |
Anti-emetic, Antivertigo, H1 receptor antagonist |
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| Comment |
Prevention and treatment of nausea, vomiting, or vertigo of motion sickness
|
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AA Aminoalkyl ethers
R06AA11 Dimenhydrinate
D00520 Dimenhydrinate (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
133 Vertigo agents
1331 Dimenhydrinates
D00520 Dimenhydrinate (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
06 Antivertigo drugs (incl. motion/morning sickness remedies)
D00520 Dimenhydrinate (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Dimenhydrinate
D00520 Dimenhydrinate (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00390 Diphenhydramine
D00520 Dimenhydrinate
Respiratory system agent
DG01616 Xanthine derivative
D00520 Dimenhydrinate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D00520 Dimenhydrinate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00520 Dimenhydrinate (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00520 Dimenhydrinate
D00520 Dimenhydrinate tablets
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00390 Diphenhydramine
|
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| Other DBs |
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| KCF data |
ATOM 33
1 C8y C 24.0335 -15.5458
2 C8y C 24.0335 -16.9748
3 C8y C 25.2341 -14.8371
4 N4x N 22.7217 -15.1124
5 N4y N 25.2341 -17.6599
6 N5x N 22.7217 -17.4080
7 N4y N 26.4579 -15.5750
8 O5x O 25.2341 -13.4551
9 C8y C 21.9077 -16.2720
10 C8y C 26.4579 -16.9220
11 C1a C 25.2341 -19.0946
12 C1a C 27.7111 -14.8957
13 X Cl 20.5022 -16.2778
14 O5x O 27.7111 -17.6248
15 C1c C 13.1842 -16.5304
16 C8y C 11.9719 -17.2389
17 C8y C 14.4022 -17.2389
18 O2a O 13.1900 -15.1308
19 C8x C 11.9719 -18.6326
20 C8x C 10.7597 -16.5304
21 C8x C 14.3965 -18.6326
22 C8x C 15.6088 -16.5304
23 C1b C 14.4022 -14.4280
24 C8x C 10.7597 -19.3296
25 C8x C 9.5475 -17.2389
26 C8x C 15.6088 -19.3296
27 C8x C 16.8209 -17.2389
28 C8x C 9.5475 -18.6326
29 C8x C 16.8150 -18.6326
30 C1b C 15.6064 -15.1220
31 N1c N 16.7880 -14.4384
32 C1a C 17.9856 -15.1287
33 C1a C 16.7870 -13.0368
BOND 35
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 1
10 5 11 1
11 7 12 1
12 9 13 1
13 10 14 2
14 6 9 2
15 7 10 1
16 15 16 1
17 15 17 1
18 15 18 1
19 16 19 1
20 16 20 2
21 17 21 2
22 17 22 1
23 18 23 1
24 19 24 2
25 20 25 1
26 21 26 1
27 22 27 2
28 24 28 1
29 26 29 2
30 25 28 2
31 27 29 1
32 23 30 1
33 30 31 1
34 31 32 1
35 31 33 1
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