KEGG   DRUG: Cromolyn sodium
Entry
D00526                      Drug                                   
Name
Cromolyn sodium (USP);
Sodium cromoglicate (JP18);
Gastrocrom (TN);
Intal (TN)
Product
  Generic
Formula
C23H14O11. 2Na
Exact mass
512.0332
Mol weight
512.3302
Structure
Simcomp
Class
Anti-allergic agent
 DG01805  Mediator release inhibitor
Remark
Therapeutic category: 1319 1329 2259 4490
ATC code: A07EB01 D11AH03 R01AC01 R03BC01 S01GX01
Chemical structure group: DG00098
Product (DG00098): D00526<JP/US>
Efficacy
Antiallergic, Antiasthmatic, Chemical mediator release inhibitor
Comment
Inhibition of Clc chloride channel
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EB Antiallergic agents, excl. corticosteroids
     A07EB01 Cromoglicic acid
      D00526  Cromolyn sodium (USP) <JP/US>
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AH Agents for dermatitis, excluding corticosteroids
     D11AH03 Cromoglicic acid
      D00526  Cromolyn sodium (USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC01 Cromoglicic acid
      D00526  Cromolyn sodium (USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BC Antiallergic agents, excl. corticosteroids
     R03BC01 Cromoglicic acid
      D00526  Cromolyn sodium (USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX01 Cromoglicic acid
      D00526  Cromolyn sodium (USP) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Cromolyn
   D00526  Cromolyn sodium (USP)
 Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Mast Cell Stabilizer
    Cromolyn
     D00526  Cromolyn sodium (USP)
 Respiratory Tract/Pulmonary Agents
  Mast Cell Stabilizers
   Cromolyn
    D00526  Cromolyn sodium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00526  Cromolyn sodium (USP); Sodium cromoglicate (JP18)
   132  Otic and nasal agents
    1329  Others
     D00526  Cromolyn sodium (USP); Sodium cromoglicate (JP18)
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D00526  Cromolyn sodium (USP); Sodium cromoglicate (JP18)
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D00526  Cromolyn sodium (USP); Sodium cromoglicate (JP18)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for ophthalmologic use
  64 Allergy eye drops
   D00526  Cromolyn sodium (USP)
 Agents for otolaryngologic use
  70 Nasal sprays for inflammation
   D00526  Cromolyn sodium (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Cromoglicic acid
    D00526  Cromolyn sodium (USP)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01805  Mediator release inhibitor
   DG00098  Cromoglicic acid
    D00526  Cromolyn sodium
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00526  Sodium cromoglicate
Rx-to-OTC switch list in the USA [br08315.html]
 D00526
Rx-to-OTC switch list in Japan [br08314.html]
 D00526
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01805  Mediator release inhibitor
   DG00098  Cromoglicic acid
Other DBs
CAS: 15826-37-6
PubChem: 7847592
ChEBI: 128458
LigandBox: D00526
NIKKAJI: J9.015H
KCF data

ATOM        36
            1   Z   Na    4.4450   -7.9452 #+
            2   Z   Na   24.9023   -8.0156 #+
            3   C8x C     8.9600   -6.5800
            4   C8y C     8.9600   -7.9800
            5   O2x O    10.1724   -8.6800
            6   C8y C    11.3849   -7.9800
            7   C8y C    11.3849   -6.5800
            8   C8y C    10.1724   -5.8800
            9   C8x C    12.5973   -8.6800
            10  C8x C    13.8097   -7.9800
            11  C8x C    13.8097   -6.5800
            12  C8y C    12.5973   -5.8800
            13  O1a O    15.0222   -5.8800
            14  C1c C    15.0222   -4.4800
            15  C1b C    13.8097   -3.7800
            16  O2a O    12.5973   -4.4800
            17  C8x C    16.2346   -6.5800
            18  C8y C    17.4470   -5.8800
            19  O2a O    17.4470   -4.4800
            20  C1b C    16.2346   -3.7800
            21  C8x C    16.2346   -7.9800
            22  C8x C    17.4470   -8.6800
            23  C8y C    18.6595   -7.9800
            24  C8y C    18.6595   -6.5800
            25  O2x O    19.8719   -8.6800
            26  C8y C    21.0844   -7.9800
            27  C8x C    21.0844   -6.5800
            28  C8y C    19.8719   -5.8800
            29  C6a C    22.2968   -8.6800
            30  O6a O    23.5092   -7.9800 #-
            31  O6a O     6.5351   -7.9800 #-
            32  C6a C     7.7476   -8.6800
            33  O6a O     7.7476  -10.0798
            34  O5x O    10.1724   -4.4802
            35  O5x O    19.8719   -4.4800
            36  O6a O    22.2968  -10.0796
BOND        37
            1     3   4 2
            2     4   5 1
            3     5   6 1
            4     6   7 1
            5     7   8 1
            6     3   8 1
            7     6   9 2
            8     9  10 1
            9    10  11 2
            10   11  12 1
            11    7  12 2
            12   13  14 1
            13   14  15 1
            14   15  16 1
            15   12  16 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   14  20 1
            20   17  21 2
            21   21  22 1
            22   22  23 2
            23   23  24 1
            24   18  24 2
            25   23  25 1
            26   25  26 1
            27   26  27 2
            28   27  28 1
            29   24  28 1
            30   26  29 1
            31   29  30 1
            32   31  32 1
            33    4  32 1
            34   32  33 2
            35    8  34 2
            36   28  35 2
            37   29  36 2

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