KEGG   DRUG: Zonisamide
Entry
D00538                      Drug                                   
Name
Zonisamide (JP18/USP/INN);
Excegran (TN)
Product
ZONEGRAN (Concordia Pharmaceuticals), ZONISADE (Azurity Phramaceuticals)
  Generic
ZONISAMIDE (Advanced Rx Pharmacy of Tennessee), ZONISAMIDE (American Health Packaging), ZONISAMIDE (Aurobindo Pharma Limited), ZONISAMIDE (AvPAK), ZONISAMIDE (BluePoint Laboratories), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Cipla USA), ZONISAMIDE (Direct_Rx), ZONISAMIDE (Direct_Rx), ZONISAMIDE (Exelan Pharmaceuticals), ZONISAMIDE (Glenmark Pharmaceuticals), ZONISAMIDE (NCS HealthCare of KY), ZONISAMIDE (Preferred Pharmaceuticals), ZONISAMIDE (Proficient Rx LP), ZONISAMIDE (Proficient Rx LP), ZONISAMIDE (Proficient Rx LP), ZONISAMIDE (REMEDYREPACK), ZONISAMIDE (REMEDYREPACK), ZONISAMIDE (REMEDYREPACK), ZONISAMIDE (Sun Pharmaceutical Industries), ZONISAMIDE (Unichem Pharmaceuticals (USA)), ZONISAMIDE (Viona Pharmaceuticals), ZONISAMIDE (Zydus Lifesciences Limited)
Formula
C8H8N2O3S
Exact mass
212.0256
Mol weight
212.2257
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Neuropsychiatric agent
 DG03199  Antiepileptic agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C07504
Therapeutic category: 1139 1169
ATC code: N03AX15
Product: D00538<JP/US>
Efficacy
Anticonvulsant, Antiepileptic
Comment
Benzisoxazole derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07033  Anticonvulsants
map07057  Antiparkinsonian agents
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX15 Zonisamide
      D00538  Zonisamide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Zonisamide
    D00538  Zonisamide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00538  Zonisamide (JP18/USP/INN)
   116  Antiparkinsonian agents
    1169  Others
     D00538  Zonisamide (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    D00538  Zonisamide
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00538  Zonisamide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D00538  Zonisamide
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00538  Zonisamide
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN2A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN3A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN4A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN5A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN8A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN9A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN10A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN11A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
   Calcium channels
    CACNA1-T
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00538  Zonisamide
  D00538  Zonisamide tablets
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00538
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00538
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00538
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00538
Other DBs
CAS: 68291-97-4
PubChem: 7847604
ChEBI: 10127
PDB-CCD: ZON[PDBj]
LigandBox: D00538
NIKKAJI: J20.559A
KCF data

ATOM        14
            1   C8y C    23.2246  -18.0420
            2   C8y C    24.5519  -17.6112
            3   C8y C    23.2246  -19.4447
            4   C8x C    22.0139  -17.3435
            5   N5x N    25.3783  -18.7462
            6   O2x O    24.5576  -19.8813
            7   C8x C    22.0139  -20.1433
            8   C8x C    20.7973  -18.0420
            9   C8x C    20.7973  -19.4447
            10  C1b C    24.5519  -16.2112
            11  S4a S    25.7651  -15.5107
            12  O3c O    26.9775  -14.8107
            13  N1a N    25.0763  -14.3183
            14  O3c O    26.4767  -16.7426
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     7   9 2
            9     5   6 1
            10    8   9 1
            11    2  10 1
            12   10  11 1
            13   11  12 2
            14   11  13 1
            15   11  14 2

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