KEGG   DRUG: Glycopyrrolate
Entry
D00540                      Drug                                   
Name
Glycopyrrolate (USP);
Glycopyrronium bromide (JAN/INN);
Cuvposa (TN);
Robinul (TN);
Seebri breezhaler (TN)
Product
CUVPOSA (Merz Pharmaceuticals), DARTISLA ODT (Edenbridge Pharmaceuticals LLC.), GLYCOPYRROLATE (Casper Pharma LLC), GLYCOPYRROLATE (Fresenius Kabi USA), GLYRX-PF (Exela Pharma Sciences), ROBINUL (West-Ward Pharmaceuticals Corp.)
  Generic
GLYCATE (Intra-Sana Laboratories), GLYCOPYRROLATE (Accord Healthcare), GLYCOPYRROLATE (Alembic Labs LLC), GLYCOPYRROLATE (Alembic Pharmaceuticals), GLYCOPYRROLATE (American Regent), GLYCOPYRROLATE (Amneal Pharmaceuticals LLC), GLYCOPYRROLATE (Amneal Pharmaceuticals LLC), GLYCOPYRROLATE (Apotex Corp.), GLYCOPYRROLATE (Athenex Pharmaceutical Division), GLYCOPYRROLATE (AuroMedics Pharma LLC), GLYCOPYRROLATE (Aurolife Pharma LLC), GLYCOPYRROLATE (BE Pharmaceuticals), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Bryant Ranch Prepack), GLYCOPYRROLATE (Camber Pharmaceuticals), GLYCOPYRROLATE (Caplin Steriles Limited), GLYCOPYRROLATE (Cardinal Health 107), GLYCOPYRROLATE (Cardinal Health 107), GLYCOPYRROLATE (Chartwell RX), GLYCOPYRROLATE (Civica), GLYCOPYRROLATE (Civica), GLYCOPYRROLATE (Dr. Reddy's Laboratories Limited), GLYCOPYRROLATE (FH2 Pharma LLC), GLYCOPYRROLATE (Fresenius Kabi USA), GLYCOPYRROLATE (Fresenius Kabi USA), GLYCOPYRROLATE (Fresenius Kabi USA), GLYCOPYRROLATE (Fresenius Kabi USA), GLYCOPYRROLATE (Gland Pharma Limited), GLYCOPYRROLATE (Golden State Medical Supply), GLYCOPYRROLATE (HF Acquisition Co LLC), GLYCOPYRROLATE (HF Acquisition Co LLC), GLYCOPYRROLATE (HF Acquisition Co LLC), GLYCOPYRROLATE (HF Acquisition Co LLC), GLYCOPYRROLATE (HF Acquisition Co LLC), GLYCOPYRROLATE (Henry Schein), GLYCOPYRROLATE (Henry Schein), GLYCOPYRROLATE (Henry Schein), GLYCOPYRROLATE (Henry Schein), GLYCOPYRROLATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), GLYCOPYRROLATE (Hikma Pharmaceuticals USA), GLYCOPYRROLATE (Hikma Pharmaceuticals USA), GLYCOPYRROLATE (LGM PHARMA SOLUTIONS), GLYCOPYRROLATE (Leading Pharma), GLYCOPYRROLATE (Lifestar Pharma LLC), GLYCOPYRROLATE (Major Pharmaceuticals), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Medical Purchasing Solutions), GLYCOPYRROLATE (Meitheal Pharmaceuticals), GLYCOPYRROLATE (Meitheal Pharmaceuticals), GLYCOPYRROLATE (Meitheal Pharmaceuticals), GLYCOPYRROLATE (Merz Pharmaceuticals), GLYCOPYRROLATE (NORTHSTAR RX LLC), GLYCOPYRROLATE (Nivagen Pharmaceuticals), GLYCOPYRROLATE (NorthStar Rx LLC), GLYCOPYRROLATE (NorthStar RxLLC), GLYCOPYRROLATE (Par Pharmaceutical), GLYCOPYRROLATE (Par Pharmaceutical), GLYCOPYRROLATE (Piramal Critical Care), GLYCOPYRROLATE (Preferred Pharmaceuticals), GLYCOPYRROLATE (Quinn Pharmaceuticals), GLYCOPYRROLATE (REMEDYREPACK), GLYCOPYRROLATE (REMEDYREPACK), GLYCOPYRROLATE (Rising Pharma Holdings), GLYCOPYRROLATE (Sandoz), GLYCOPYRROLATE (Solco Healthcare US), GLYCOPYRROLATE (Solco Healthcare US), GLYCOPYRROLATE (Somerset Therapeutics), GLYCOPYRROLATE (Somerset Therapeutics), GLYCOPYRROLATE (Xiromed LLC), GLYCOPYRROLATE (Xiromed), GLYCOPYRROLATE (Zydus Lifesciences Limited), GLYCOPYRROLATE (Zydus Pharmaceuticals USA), GLYCOPYRROLATE 1ML (XIROMED LLC), GLYCOPYRROLATE ORAL SOLUTION (Suven Pharmaceuticals Limited), GLYCOPYRROLATE ORAL SOLUTION (Taro Pharmaceuticals U.S.A.)
Formula
C19H28NO3. Br
Exact mass
397.1253
Mol weight
398.3345
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
Therapeutic category: 2259
ATC code: A03AB02 D11AA01 R03BB06
Chemical structure group: DG02467
Product (DG02467): D00540<JP/US> D10939<JP/US>
Product (mixture): D10505<JP> D11036<JP/US> D11584<JP/US> D11861<JP>
Efficacy
Anti-ulcerative, Bronchodilator, Muscarinic acetylcholine receptor antagonist
  Disease
Peptic ulcer [DS:H01634]
Chronic obstructive pulmonary disease [DS:H01714]
Comment
Quaternary ammonium compound
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04971  Gastric acid secretion
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03A DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
    A03AB Synthetic anticholinergics, quaternary ammonium compounds
     A03AB02 Glycopyrronium bromide
      D00540  Glycopyrrolate (USP) <JP/US>
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AA Antihidrotics
     D11AA01 Glycopyrronium
      D00540  Glycopyrrolate (USP) <JP/US>
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BB Anticholinergics
     R03BB06 Glycopyrronium bromide
      D00540  Glycopyrrolate (USP) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Glycopyrrolate
    D00540  Glycopyrrolate (USP)
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Anticholinergic
   Glycopyrrolate
    D00540  Glycopyrrolate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D00540  Glycopyrrolate (USP); Glycopyrronium bromide (JAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG02467  Glycopyrronium
    D00540  Glycopyrrolate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM3
     D00540  Glycopyrrolate (USP) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00540
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00540
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG02467  Glycopyrronium
Other DBs
CAS: 596-51-0
PubChem: 7847606
ChEBI: 5494
LigandBox: D00540
NIKKAJI: J243.999I
KCF data

ATOM        24
            1   C1d C    24.1031  -22.1674
            2   C7a C    22.9701  -22.8047
            3   O7a O    21.7662  -22.1674
            4   O6a O    22.9701  -24.2210
            5   C1y C    20.4915  -22.8756
            6   C1x C    19.4128  -22.0966
            7   C1x C    20.0908  -24.2414
            8   N2y N    18.2555  -22.8879 #+
            9   C1x C    18.7293  -24.2018
            10  C1y C    25.3216  -22.8892
            11  C1x C    25.7607  -24.2172
            12  C1x C    27.1619  -24.2138
            13  C1x C    27.5915  -22.8800
            14  C1x C    26.4559  -22.0593
            15  C8y C    24.1031  -20.7511
            16  C8x C    25.3296  -20.0429
            17  C8x C    25.3296  -18.6266
            18  C8x C    24.1031  -17.9184
            19  C8x C    22.8766  -18.6266
            20  C8x C    22.8766  -20.0429
            21  O1a O    25.1880  -21.3176
            22  C1a C    17.0289  -22.1798
            23  C1a C    17.0289  -23.5960
            24  X   Br   17.5880  -25.3541 #-
BOND        25
            1     1   2 1
            2     2   3 1
            3     2   4 2
            4     3   5 1
            5     5   6 1
            6     5   7 1
            7     6   8 1
            8     7   9 1
            9     8   9 1
            10    1  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23    1  21 1
            24    8  22 1
            25    8  23 1

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Ontology (7)   
   KEGG BRITE (7)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
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