| Entry |
|
|---|
| Name |
Midazolam (JAN/USP/INN);
Dormicum (TN);
Buccolam (TN);
Nayzilam (TN) |
|---|
| Product |
|
|---|
| Formula |
C18H13ClFN3
|
|---|
| Exact mass |
325.0782
|
|---|
| Mol weight |
325.7673
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG01567 GABA-A receptor agonist
DG03199 Antiepileptic agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00920): | D00550<JP/US> D00696<US> |
|
|---|
| Efficacy |
Anesthetic (intravenous), Anticonvulsant, Sedative-hypnotic |
|---|
| Comment |
Benzodiazepine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CD Benzodiazepine derivatives
N05CD08 Midazolam
D00550 Midazolam (JAN/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D00550 Midazolam (JAN/USP/INN)
113 Antiepileptics
1139 Others
D00550 Midazolam (JAN/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG00920 Midazolam
D00550 Midazolam
DG01567 GABA-A receptor agonist
DG00920 Midazolam
D00550 Midazolam
DG03199 Antiepileptic agent
DG00920 Midazolam
D00550 Midazolam
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00920 Midazolam
D00550 Midazolam
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D00550 Midazolam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D00550 Midazolam (JAN/USP/INN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00550
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D00550
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG00920 Midazolam
DG01567 GABA-A receptor agonist
DG00920 Midazolam
DG03199 Antiepileptic agent
DG00920 Midazolam
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00920 Midazolam
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 23
1 C2y C 16.5834 -17.0194
2 C8y C 15.7413 -15.9098
3 C8y C 16.0765 -14.5530
4 N4y N 17.3375 -13.9749
5 N2x N 17.9892 -17.0446
6 C8y C 18.5911 -14.5972
7 C1x C 18.8776 -15.9659
8 C8x C 15.0694 -13.5846
9 C8x C 13.7274 -13.9727
10 C8y C 13.3922 -15.3295
11 C8x C 14.3993 -16.2976
12 X Cl 12.0274 -15.7239
13 C8y C 15.9489 -18.2691
14 C8x C 14.5473 -18.2691
15 C8x C 13.8473 -19.4816
16 C8x C 14.5473 -20.6940
17 C8x C 15.9489 -20.6940
18 C8y C 16.6489 -19.4816
19 X F 18.0598 -19.4817
20 C8x C 19.5704 -13.5973
21 N5x N 18.9220 -12.3570
22 C8y C 17.5420 -12.5904
23 C1a C 16.5611 -11.6294
BOND 26
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 10 12 1
14 1 13 1
15 13 14 1
16 14 15 2
17 15 16 1
18 16 17 2
19 17 18 1
20 13 18 2
21 18 19 1
22 6 20 2
23 20 21 1
24 21 22 2
25 4 22 1
26 22 23 1
|
|---|
