| Entry |
|
|---|
| Name |
Ethinyl estradiol (USP);
Ethinylestradiol (JP18/INN);
Estinyl (TN) |
|---|
| Formula |
C20H24O2
|
|---|
| Exact mass |
296.1776
|
|---|
| Mol weight |
296.4034
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Hormonal agent
DG01986 Estrogen
DG01584 Estrogen receptor agonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 2474 |
| Product (DG00461): | D00554<JP> |
|
|---|
| Efficacy |
Antineoplastic, Menstruation disorder agent, Estrogen receptor agonist |
|---|
| Comment |
Estrogen
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Network |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
|---|
| Structure map |
| map07226 | Progesterone, androgen and estrogen receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
G03C ESTROGENS
G03CA Natural and semisynthetic estrogens, plain
G03CA01 Ethinylestradiol
D00554 Ethinyl estradiol (USP) <JP>
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02A HORMONES AND RELATED AGENTS
L02AA Estrogens
L02AA03 Ethinylestradiol
D00554 Ethinyl estradiol (USP) <JP>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
Estrogens
Ethinyl Estradiol
D00554 Ethinyl estradiol (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
247 Estrogen and progesterone preparations
2474 Ethinylestradiols
D00554 Ethinyl estradiol (USP); Ethinylestradiol (JP18/INN)
Classification of Japanese OTC drugs [BR:br08313]
Drugs for women
51 Other drugs for women
D00554 Ethinyl estradiol (USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Ethinylestradiol
D00554 Ethinyl estradiol (USP)
Second-class OTC drugs
Inorganic and organic chemicals
Ethinylestradiol
D00554 Ethinyl estradiol (USP)
Drug groups [BR:br08330]
Hormonal agent
DG01986 Estrogen
DG00461 Ethinylestradiol
D00554 Ethinyl estradiol
DG01584 Estrogen receptor agonist
DG00461 Ethinylestradiol
D00554 Ethinyl estradiol
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00461 Ethinylestradiol
D00554 Ethinyl estradiol
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00461 Ethinylestradiol
D00554 Ethinyl estradiol
Drug classes [BR:br08332]
Endocrine and hormonal agent
DG01986 Estrogen
D00554 Ethinyl estradiol
DG01584 Estrogen receptor agonist
D00554 Ethinyl estradiol
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
Estrogen receptor
NR3A1 (ESR1)
D00554 Ethinyl estradiol (USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00554 Ethinylestradiol
D00554 Ethinylestradiol tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00554
Drug groups [BR:br08330]
Hormonal agent
DG01986 Estrogen
DG00461 Ethinylestradiol
DG01584 Estrogen receptor agonist
DG00461 Ethinylestradiol
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00461 Ethinylestradiol
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00461 Ethinylestradiol
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 22
1 C1y C 20.4641 -16.5790
2 C1z C 20.4525 -15.2599
3 C1y C 19.3184 -17.2675
4 C1x C 22.7610 -16.5558
5 C1z C 21.5923 -14.5829
6 C1x C 19.2897 -14.6060
7 C1a C 20.4069 -13.9233
8 C1y C 18.1671 -16.6137
9 C1x C 19.3474 -18.5982
10 C1x C 22.7435 -15.2310
11 C3b C 22.6337 -13.9233
12 C1x C 18.2198 -15.2887
13 C8y C 17.0216 -17.3022
14 C1x C 18.2020 -19.2926
15 C3a C 23.6808 -13.2580
16 C8y C 17.0390 -18.6328
17 C8x C 15.8414 -16.6542
18 C8x C 15.8992 -19.3387
19 C8x C 14.6901 -17.3484
20 C8y C 14.7190 -18.6967
21 O1a O 13.5735 -19.3908
22 O1a O 21.5923 -12.9182
BOND 25
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 2 7 1 #Up
7 3 8 1
8 3 9 1
9 4 10 1
10 5 11 1 #Down
11 6 12 1
12 8 13 1
13 9 14 1
14 11 15 3
15 13 16 2
16 13 17 1
17 16 18 1
18 17 19 2
19 18 20 2
20 20 21 1
21 5 10 1
22 8 12 1
23 14 16 1
24 19 20 1
25 5 22 1 #Up
|
|---|
