KEGG   DRUG: Pimozide
Entry
D00560                      Drug                                   
Name
Pimozide (JP18/USP/INN);
Orap (TN)
Product
  Generic
Formula
C28H29F2N3O
Exact mass
461.2279
Mol weight
461.5462
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07566
ATC code: N05AG02
Product: D00560<US>
Efficacy
Antipsychotic, Dopamine receptor antagonist
  Disease
Tourette’s disorder [DS:H00862]
Comment
Diphenylbutylpiperidine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
ADRA2A [HSA:150] [KO:K04138]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565]
Interaction
Structure map
map07031  Antipsychotics - butyrophenones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AG Diphenylbutylpiperidine derivatives
     N05AG02 Pimozide
      D00560  Pimozide (JP18/USP/INN) <US>
USP drug classification [BR:br08302]
 Antipsychotics
  1st Generation/Typical
   Pimozide
    D00560  Pimozide (JP18/USP/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D00560  Pimozide
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00560  Pimozide
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2A
     D00560  Pimozide (JP18/USP/INN) <US>
   Dopamine
    DRD2
     D00560  Pimozide (JP18/USP/INN) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00560  Pimozide
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00560
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00560
Other DBs
CAS: 2062-78-4
PubChem: 7847626
ChEBI: 8212
PDB-CCD: 1II[PDBj]
LigandBox: D00560
NIKKAJI: J3.698F
KCF data

ATOM        34
            1   C8x C     3.3600  -23.5200
            2   C8y C     3.3600  -24.9200
            3   C8x C     4.5724  -25.6200
            4   C8x C     5.7849  -24.9200
            5   C8y C     5.7849  -23.5200
            6   C8x C     4.5724  -22.8200
            7   C8x C     8.2097  -24.9200
            8   C8y C     8.2097  -23.5200
            9   C1c C     6.9973  -22.8200
            10  C8x C     9.4222  -25.6200
            11  C8y C    10.6346  -24.9200
            12  C8x C    10.6346  -23.5200
            13  C8x C     9.4222  -22.8200
            14  X   F     2.1476  -25.6200
            15  X   F    11.8511  -25.6223
            16  C1b C     6.9973  -21.4200
            17  C1b C     8.2118  -20.7188
            18  C1b C     9.4083  -21.4098
            19  N1y N    10.5951  -20.7246
            20  C1x C    11.7866  -21.4128
            21  C1x C    12.9991  -20.7129
            22  C1y C    12.9993  -19.3129
            23  C1x C    11.8078  -18.6248
            24  C1x C    10.5953  -19.3246
            25  N4y N    14.2241  -18.6058
            26  C8y C    14.2241  -17.2058
            27  O5x O    13.0074  -16.5032
            28  C8y C    15.5556  -19.0384
            29  C8y C    16.3785  -17.9058
            30  N4x N    15.5556  -16.7732
            31  C8x C    17.7785  -17.9058
            32  C8x C    18.4851  -19.1295
            33  C8x C    17.7922  -20.3294
            34  C8x C    16.3803  -20.3296
BOND        38
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    2  14 1
            16   11  15 1
            17    9  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   19  24 1
            27   22  25 1
            28   25  26 1
            29   26  27 2
            30   25  28 1
            31   28  29 2
            32   29  30 1
            33   26  30 1
            34   29  31 1
            35   31  32 2
            36   32  33 1
            37   33  34 2
            38   34  28 1

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