KEGG   DRUG: Fenofibrate
Entry
D00565                      Drug                                   
Name
Fenofibrate (JP18/USP/INN);
Antara (TN);
Lipantil (TN);
Lipofen (TN);
Tricor (TN);
Triglide (TN)
Product
ANTARA (Lupin Pharmaceuticals), ANTARA (Lupin Pharmaceuticals), FENOFIBRATE (Oceanside Pharmaceuticals), FENOGLIDE (Santarus), LIPOFEN (ANI Pharmaceuticals), TRICOR (A-S Medication Solutions), TRICOR (AbbVie), TRICOR (Aphena Pharma Solutions - Tennessee)
  Generic
FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (A-S Medication Solutions), FENOFIBRATE (ANI Pharmaceuticals), FENOFIBRATE (ANI Pharmaceuticals), FENOFIBRATE (Ajanta Pharma USA), FENOFIBRATE (Ajanta Pharma USA), FENOFIBRATE (Alembic Pharmaceuticals Limited), FENOFIBRATE (Alembic Pharmaceuticals Limited), FENOFIBRATE (Alembic Pharmaceuticals Limited), FENOFIBRATE (Alembic Pharmaceuticals Limited), FENOFIBRATE (Alembic Pharmaceuticals), FENOFIBRATE (Alembic Pharmaceuticals), FENOFIBRATE (Alembic Pharmaceuticals), FENOFIBRATE (Alembic Pharmaceuticals), FENOFIBRATE (Alembic Pharmaceuticals), FENOFIBRATE (American Health Packaging), FENOFIBRATE (American Health Packaging), FENOFIBRATE (American Health Packaging), FENOFIBRATE (Amneal Pharmaceuticals NY LLC), FENOFIBRATE (Amneal Pharmaceuticals NY LLC), FENOFIBRATE (Amneal Pharmaceuticals NY LLC), FENOFIBRATE (Amneal Pharmaceuticals of New York LLC), FENOFIBRATE (Aphena Pharma Solutions - Tennessee), FENOFIBRATE (Aphena Pharma Solutions - Tennessee), FENOFIBRATE (Aphena Pharma Solutions - Tennessee), FENOFIBRATE (Apotex Corp.), FENOFIBRATE (Aurobindo Pharma Limited), FENOFIBRATE (Aurobindo Pharma Limited), FENOFIBRATE (Aurobindo Pharma Limited), FENOFIBRATE (Austarpharma), FENOFIBRATE (AvKARE), FENOFIBRATE (AvKARE), FENOFIBRATE (AvPAK), FENOFIBRATE (AvPAK), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Bryant Ranch Prepack), FENOFIBRATE (Camber Pharmaceuticals), FENOFIBRATE (Cipla USA Inc.,), FENOFIBRATE (Cipla USA), FENOFIBRATE (Creekwood Pharmaceuticals LLC), FENOFIBRATE (Dr. Reddy's Laboratories Limited), FENOFIBRATE (Dr. Reddy's Laboratories), FENOFIBRATE (Glenmark Pharmaceuticals), FENOFIBRATE (Golden State Medical Supply), FENOFIBRATE (Golden State Medical Supply), FENOFIBRATE (Golden State Medical Supply), FENOFIBRATE (Graviti Pharmaceuticals Private Limited), FENOFIBRATE (Graviti Pharmaceuticals Private Limited), FENOFIBRATE (Laurus Labs Limited), FENOFIBRATE (Laurus Labs Limited), FENOFIBRATE (Leading Pharma), FENOFIBRATE (Leading Pharma), FENOFIBRATE (Lifestar Pharma LLC), FENOFIBRATE (Lupin Pharmaceuticals), FENOFIBRATE (Lupin Pharmaceuticals), FENOFIBRATE (Lupin Pharmaceuticals), FENOFIBRATE (Major Pharmaceuticals), FENOFIBRATE (Major Pharmaceuticals), FENOFIBRATE (Mylan Institutional), FENOFIBRATE (Mylan Pharmaceuticals), FENOFIBRATE (Mylan Pharmaceuticals), FENOFIBRATE (Mylan Pharmaceuticals), FENOFIBRATE (NCS HealthCare of KY), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (Northwind Pharmaceuticals), FENOFIBRATE (NuCare Pharmaceuticals), FENOFIBRATE (NuCare Pharmaceuticals), FENOFIBRATE (NuCare Pharmaceuticals), FENOFIBRATE (NuCare Pharmaceuticals), FENOFIBRATE (NuCare Pharmaceuticals), FENOFIBRATE (NuCare Pharmaceuticals), FENOFIBRATE (PD-Rx Pharmaceuticals), FENOFIBRATE (Preferred Pharmaceuticals), FENOFIBRATE (Preferred Pharmaceuticals), FENOFIBRATE (Preferred Pharmaceuticals), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (Proficient Rx LP), FENOFIBRATE (QUALLENT PHARMACEUTICALS HEALTH LLC), FENOFIBRATE (Quality Care Products), FENOFIBRATE (REMEDYREPACK), FENOFIBRATE (REMEDYREPACK), FENOFIBRATE (REMEDYREPACK), FENOFIBRATE (Rhodes Pharmaceuticals L.P.), FENOFIBRATE (Rhodes Pharmaceuticals L.P.), FENOFIBRATE (Solco Healthcare US), FENOFIBRATE (St. Mary's Medical Park Pharmacy), FENOFIBRATE (Sun Pharmaceutical Industries), FENOFIBRATE (Sun Pharmaceutical Industries), FENOFIBRATE (Sun Pharmaceutical Industries), FENOFIBRATE (Torrent Pharmaceuticals Limited), FENOFIBRATE (Westminster Pharmaceuticals)
Formula
C20H21ClO4
Exact mass
360.1128
Mol weight
360.8313
Structure
Simcomp
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG01733  PPAR alpha agonist
   DG01547  Fibrate
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Same as: C07586
Therapeutic category: 2183
ATC code: C10AB05
Chemical structure group: DG01548
Product (DG01548): D00565<JP/US> D08890<US>
Efficacy
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist
  Disease
Primary hypercholesterolemia or mixed dyslipidemia [DS:H01635]
Hypertriglyceridemia [DS:H01637]
Comment
Clofibrate derivative
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
  Pathway
hsa03320  PPAR signaling pathway
hsa04920  Adipocytokine signaling pathway
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07222  Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AB Fibrates
     C10AB05 Fenofibrate
      D00565  Fenofibrate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Fibric Acid Derivatives
   Fenofibrate
    D00565  Fenofibrate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2183  Clofibrates
     D00565  Fenofibrate (JP18/USP/INN)
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01733  PPAR alpha agonist
    DG01547  Fibrate
     DG01548  Fenofibrate
      D00565  Fenofibrate
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG01548  Fenofibrate
    D00565  Fenofibrate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01946  Hypolipidemic agent
   D00565  Fenofibrate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C1 (PPARA)
     D00565  Fenofibrate (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00565  Fenofibrate
  D00565  Fenofibrate tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00565
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01733  PPAR alpha agonist
    DG01547  Fibrate
     DG01548  Fenofibrate
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG01548  Fenofibrate
Other DBs
CAS: 49562-28-9
PubChem: 7847631
ChEBI: 5001
PDB-CCD: J3O[PDBj]
LigandBox: D00565
NIKKAJI: J10.021H
KCF data

ATOM        25
            1   C8y C    29.4485  -16.2910
            2   C5a C    28.2596  -16.9904
            3   C8x C    30.7073  -16.9904
            4   C8x C    29.4485  -14.8924
            5   C8y C    27.0708  -16.2910
            6   O5a O    28.2596  -18.3890
            7   C8x C    31.8961  -16.2910
            8   C8x C    30.7073  -14.1930
            9   C8x C    25.8120  -16.9904
            10  C8x C    27.0708  -14.8924
            11  C8y C    31.8961  -14.8924
            12  C8x C    24.6231  -16.2910
            13  C8x C    25.8120  -14.1930
            14  O2a O    33.0850  -14.1930
            15  C8y C    24.6231  -14.8924
            16  C1d C    34.3438  -14.8924
            17  X   Cl   23.4343  -14.1930
            18  C7a C    35.5326  -14.1930
            19  O7a O    36.7215  -14.8924
            20  O6a O    35.5326  -12.7943
            21  C1c C    37.9804  -14.1930
            22  C1a C    39.1692  -14.8924
            23  C1a C    37.9804  -12.7943
            24  C1a C    33.6445  -16.1036
            25  C1a C    35.0431  -16.1036
BOND        26
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 2
            13   11  14 1
            14   12  15 2
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   18  20 2
            20   19  21 1
            21   21  22 1
            22   21  23 1
            23    8  11 1
            24   13  15 1
            25   16  24 1
            26   16  25 1

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