| Entry |
|
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| Name |
Betaxolol hydrochloride (JP18/USP);
Betoptic (TN);
Kerlone (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C18H29NO3. HCl
|
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| Exact mass |
343.1914
|
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| Mol weight |
343.8887
|
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| Structure |
|
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG03231 Antihypertensive
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
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| Remark |
| Product (DG00315): | D00598<JP/US> |
|
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| Efficacy |
Antiglaucoma, Antihypertensive, Vasodilator, beta1-Adrenergic receptor antagonist |
|---|
| Disease |
Chronic open-angle glaucoma [DS: H00612] Hypertension [DS: H01633] |
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| Comment |
Propranolol derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AB Beta blocking agents, selective
C07AB05 Betaxolol
D00598 Betaxolol hydrochloride (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01ED Beta blocking agents
S01ED02 Betaxolol
D00598 Betaxolol hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Beta-adrenergic Blocking Agents
Beta-1 Selective
Betaxolol
D00598 Betaxolol hydrochloride (JP18/USP)
Ophthalmic Agents
Intraocular Pressure Lowering Agents
Beta-adrenergic Blocking Agents, Ophthalmic
Betaxolol
D00598 Betaxolol hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D00598 Betaxolol hydrochloride (JP18/USP)
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D00598 Betaxolol hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00315 Betaxolol
D00598 Betaxolol hydrochloride
DG03231 Antihypertensive
DG00315 Betaxolol
D00598 Betaxolol hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00315 Betaxolol
D00598 Betaxolol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D00598 Betaxolol hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D00598 Betaxolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D00598 Betaxolol hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00598 Betaxolol hydrochloride
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00315 Betaxolol
DG03231 Antihypertensive
DG00315 Betaxolol
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00315 Betaxolol
|
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| Other DBs |
|
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| KCF data |
ATOM 23
1 O2a O 18.6200 -17.2900
2 C1b C 19.8100 -16.5900
3 C1c C 21.0700 -17.2900
4 C1b C 22.2600 -16.5900
5 O1a O 21.0700 -18.6900
6 N1b N 23.4500 -17.2900
7 C1c C 24.7100 -16.5900
8 C1a C 25.9000 -17.2900
9 C1a C 24.7100 -15.1900
10 C8y C 18.6200 -18.6900
11 C8x C 17.4300 -19.3900
12 C8x C 17.4300 -20.7900
13 C8y C 18.6200 -21.4900
14 C8x C 19.8100 -20.7900
15 C8x C 19.8100 -19.3900
16 C1b C 18.6200 -22.8900
17 C1b C 17.4300 -23.6600
18 O2a O 16.2400 -22.9600
19 C1b C 15.0500 -23.6600
20 C1y C 13.7900 -23.0300
21 C1x C 12.3900 -23.0300
22 C1x C 13.0900 -21.8400
23 X Cl 25.7680 -23.2778
BOND 23
1 1 2 1
2 2 3 1
3 3 4 1
4 3 5 1
5 4 6 1
6 6 7 1
7 7 8 1
8 7 9 1
9 1 10 1
10 10 11 2
11 11 12 1
12 12 13 2
13 13 14 1
14 14 15 2
15 10 15 1
16 13 16 1
17 16 17 1
18 17 18 1
19 18 19 1
20 19 20 1
21 21 20 1
22 22 21 1
23 22 20 1
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