KEGG   DRUG: Carteolol hydrochloride
Entry
D00599                      Drug                                   
Name
Carteolol hydrochloride (JP18/USP);
Cartrol (TN);
Ocupress (TN)
Product
  Generic
CARTEOLOL HYDROCHLORIDE (Sandoz)
Formula
C16H24N2O3. HCl
Exact mass
328.1554
Mol weight
328.8343
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG03231  Antihypertensive
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 1319 2123 2149
ATC code: C07AA15 S01ED05
Chemical structure group: DG00308
Product (DG00308): D00599<JP/US>
Product (mixture): D10804<JP>
Efficacy
Antiglaucoma, Antiarrhythmic, Antihypertensive, beta-Adrenergic receptor antagonist
  Disease
Chronic open-angle glaucoma [DS:H00612]
Comment
Propranolol derivative
Target
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04540  Gap junction
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA15 Carteolol
      D00599  Carteolol hydrochloride (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED05 Carteolol
      D00599  Carteolol hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Beta-adrenergic Blocking Agents, Ophthalmic
    Carteolol
     D00599  Carteolol hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00599  Carteolol hydrochloride (JP18/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00599  Carteolol hydrochloride (JP18/USP)
   214  Antihypertensives
    2149  Others
     D00599  Carteolol hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
    DG00308  Carteolol
     D00599  Carteolol hydrochloride
  DG01653  Antiarrhythmics
   DG01806  Class II antiarrhythmic agent
    DG00308  Carteolol
     D00599  Carteolol hydrochloride
  DG03231  Antihypertensive
   DG00308  Carteolol
    D00599  Carteolol hydrochloride
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00308  Carteolol
    D00599  Carteolol hydrochloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00308  Carteolol
    D00599  Carteolol hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00599  Carteolol hydrochloride
  DG01653  Antiarrhythmics
   D00599  Carteolol hydrochloride
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D00599  Carteolol hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB
     D00599  Carteolol hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00599  Carteolol hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00599
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
    DG00308  Carteolol
  DG01653  Antiarrhythmics
   DG01806  Class II antiarrhythmic agent
    DG00308  Carteolol
  DG03231  Antihypertensive
   DG00308  Carteolol
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00308  Carteolol
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00308  Carteolol
Other DBs
CAS: 51781-21-6
PubChem: 7847665
ChEBI: 3438
LigandBox: D00599
NIKKAJI: J299.331G
KCF data

ATOM        22
            1   X   Cl   34.1717  -16.9041
            2   C1x C    24.1844  -15.2181
            3   C5x C    24.1844  -16.6229
            4   N1x N    25.4010  -17.3254
            5   C8y C    26.6177  -16.6229
            6   C8y C    26.6177  -15.2181
            7   C1x C    25.4010  -14.5157
            8   C8x C    27.8343  -17.3254
            9   C8x C    29.0509  -16.6229
            10  C8x C    29.0509  -15.2181
            11  C8y C    27.8343  -14.5157
            12  O5x O    22.9678  -17.3254
            13  O2a O    27.8343  -13.1108
            14  C1b C    29.0530  -12.4072
            15  C1c C    30.2536  -13.1006
            16  C1b C    31.4445  -12.4130
            17  O1a O    30.2537  -14.5154
            18  N1b N    32.6401  -13.1036
            19  C1d C    33.8337  -12.4145
            20  C1a C    35.0333  -11.7219
            21  C1a C    34.5265  -13.6153
            22  C1a C    33.1223  -11.1820
BOND        22
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     2   7 1
            7     5   8 2
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11    6  11 2
            12    3  12 2
            13   11  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   15  17 1
            18   16  18 1
            19   18  19 1
            20   19  20 1
            21   19  21 1
            22   19  22 1

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Pathway (1)   
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Disease (4)   
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   LigandBox (1)   
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Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (6)   
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   KEGG GENES (3)   
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