 | | DRUG: Timolol maleate | |
| Entry |
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| Name |
Timolol maleate (JP18/USP);
Blocadren (TN);
Istalol (TN);
Timoptic (TN) |
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| Product |
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| Generic |
TIMOLOL MALEATE (A-S Medication Solutions), TIMOLOL MALEATE (A-S Medication Solutions), TIMOLOL MALEATE (Apotex Corp), TIMOLOL MALEATE (Armas Pharmaceuticals), TIMOLOL MALEATE (Athem LLC), TIMOLOL MALEATE (Aurobindo Pharma Limited), TIMOLOL MALEATE (BAUSCH & LOMB INCORPORATED), TIMOLOL MALEATE (Bausch & Lomb Americas), TIMOLOL MALEATE (Bausch & Lomb Americas), TIMOLOL MALEATE (Bausch & Lomb Americas), TIMOLOL MALEATE (Bausch & Lomb Americas), TIMOLOL MALEATE (Bausch & Lomb Incorporated), TIMOLOL MALEATE (Ingenus Pharmaceuticals), TIMOLOL MALEATE (Lifestar Pharma LLC), TIMOLOL MALEATE (Medsource Pharmaceuticals), TIMOLOL MALEATE (Micro Labs Limited), TIMOLOL MALEATE (Micro Labs Limited), TIMOLOL MALEATE (Mylan Pharmaceuticals), TIMOLOL MALEATE (Oceanside Pharmaceuticals), TIMOLOL MALEATE (Oceanside Pharmaceuticals), TIMOLOL MALEATE (Pacific Pharma), TIMOLOL MALEATE (Rising Pharma Holdings), TIMOLOL MALEATE (Sandoz), TIMOLOL MALEATE OPHTHALMIC GEL FORMING SOLUTION (FOSUN PHARMA USA), TIMOLOL MALEATE OPHTHALMIC GEL FORMING SOLUTION (Gland Pharma Limited), TIMOLOL MALEATE OPHTHALMIC GEL FORMING SOLUTION 0.25% (Dr. Reddy's Laboratories), TIMOLOL MALEATE OPHTHALMIC GEL FORMING SOLUTION 0.25% (NorthStar RxLLC), TIMOLOL MALEATE OPHTHALMIC GEL FORMING SOLUTION, 0.25% (Alembic Pharmaceuticals), TIMOPTIC IN OCUDOSE (Amring Pharmaceuticals) |
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| Formula |
C13H24N4O3S. C4H4O4
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| Exact mass |
432.1679
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| Mol weight |
432.4918
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| Structure |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
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| Remark |
| Therapeutic category: | 1319 |
| Product (DG00306): | D00378<US> D00603<JP/US> |
| Product (mixture): | D07505<JP> D08493<JP/US> D09815<JP> D10298<JP/US> D10512<JP> D10569<JP> |
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| Efficacy |
Antiglaucoma, beta-Adrenergic receptor antagonist |
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| Disease |
Open-angle glaucoma [DS: H00612] |
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| Comment |
Propranolol derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA06 Timolol
D00603 Timolol maleate (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01ED Beta blocking agents
S01ED01 Timolol
D00603 Timolol maleate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antimigraine Agents
Antimigraine Agents, Other
Timolol
D00603 Timolol maleate (JP18/USP)
Cardiovascular Agents
Beta-adrenergic Blocking Agents
Non-Selective
Timolol
D00603 Timolol maleate (JP18/USP)
Ophthalmic Agents
Intraocular Pressure Lowering Agents
Beta-adrenergic Blocking Agents, Ophthalmic
Timolol
D00603 Timolol maleate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D00603 Timolol maleate (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00306 Timolol
D00603 Timolol maleate
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00306 Timolol
D00603 Timolol maleate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00306 Timolol
D00603 Timolol maleate
Drug classes [BR:br08332]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D00603 Timolol maleate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D00603 Timolol maleate (JP18/USP) <JP/US>
ADRB2
D00603 Timolol maleate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00603 Timolol maleate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00603
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00306 Timolol
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00306 Timolol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00306 Timolol
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| Other DBs |
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| KCF data |
ATOM 29
1 C2b C 27.1995 -15.4829
2 C2b C 25.5020 -15.4829
3 C6a C 27.8361 -16.6145
4 C6a C 24.8653 -16.6852
5 O6a O 27.1995 -17.8170
6 O6a O 29.2508 -16.6145
7 O6a O 23.4508 -16.6852
8 O6a O 25.5020 -17.8170
9 C1b C 14.1400 -15.9600
10 C1c C 15.3300 -16.6600
11 O2a O 12.9500 -16.6600
12 C1b C 16.5200 -15.9600
13 N1b N 17.7100 -16.6600
14 C1d C 18.9000 -15.9600
15 C1a C 20.1600 -16.6600
16 C1a C 18.9000 -14.5600
17 C1a C 20.1600 -15.2600
18 O1a O 15.3300 -18.0600
19 C8y C 12.9500 -18.0600
20 C8y C 11.8300 -18.9700
21 N5x N 12.2500 -20.2300
22 S2x S 13.6500 -20.2300
23 N5x N 14.0700 -18.9700
24 O2x O 8.1200 -16.8000
25 C1x C 8.1200 -18.2700
26 C1x C 9.3100 -18.9700
27 N1y N 10.5700 -18.2700
28 C1x C 10.5700 -16.8000
29 C1x C 9.3100 -16.1000
BOND 29
1 1 2 2
2 1 3 1
3 2 4 1
4 3 5 1
5 3 6 2
6 4 7 1
7 4 8 2
8 9 10 1
9 9 11 1
10 10 12 1
11 12 13 1
12 13 14 1
13 14 15 1
14 14 16 1
15 14 17 1
16 10 18 1 #Down
17 11 19 1
18 19 20 1
19 20 21 2
20 21 22 1
21 22 23 1
22 19 23 2
23 24 25 1
24 25 26 1
25 26 27 1
26 27 28 1
27 28 29 1
28 24 29 1
29 27 20 1
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