KEGG   DRUG: Guanfacine hydrochloride
Entry
D00606                      Drug                                   
Name
Guanfacine hydrochloride (JAN/USP);
Intuniv (TN);
Tenex (TN)
Product
  Generic
GUANFACINE (Actavis Pharma), GUANFACINE (Actavis Pharma), GUANFACINE (Advagen Pharma), GUANFACINE (Ajanta Pharma USA), GUANFACINE (Alembic Pharmaceuticals Limited), GUANFACINE (Alembic Pharmaceuticals), GUANFACINE (Aurobindo Pharma Limited), GUANFACINE (AvKARE), GUANFACINE (Bryant Ranch Prepack), GUANFACINE (Bryant Ranch Prepack), GUANFACINE (Bryant Ranch Prepack), GUANFACINE (Bryant Ranch Prepack), GUANFACINE (Bryant Ranch Prepack), GUANFACINE (Bryant Ranch Prepack), GUANFACINE (Bryant Ranch Prepack), GUANFACINE (Epic Pharma), GUANFACINE (Golden State Medical Supply), GUANFACINE (Major Pharmaceuticals), GUANFACINE (NORTHSTAR RXLLC), GUANFACINE (Proficient Rx LP), GUANFACINE (Proficient Rx LP), GUANFACINE (PuraCap Laboratories LLC dba Blu Pharmaceuticals), GUANFACINE (REMEDYREPACK), GUANFACINE (REMEDYREPACK), GUANFACINE (REMEDYREPACK), GUANFACINE (Slate Run Pharmaceuticals), GUANFACINE (Sun Pharmaceutical Industries), GUANFACINE (TWi Pharmaceuticals), GUANFACINE (i3 Pharmaceuticals), GUANFACINE ER (Direct_Rx), GUANFACINE EXTENDED-RELEASE (A-S Medication Solutions), GUANFACINE EXTENDED-RELEASE (Apotex Corp.), GUANFACINE EXTENDED-RELEASE (Bryant Ranch Prepack), GUANFACINE EXTENDED-RELEASE (Bryant Ranch Prepack), GUANFACINE EXTENDED-RELEASE (Bryant Ranch Prepack), GUANFACINE EXTENDED-RELEASE (Bryant Ranch Prepack), GUANFACINE EXTENDED-RELEASE (Bryant Ranch Prepack), GUANFACINE HYDROCHLORIDE (A-S Medication Solutions), GUANFACINE HYDROCHLORIDE (American Health Packaging), GUANFACINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), GUANFACINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), GUANFACINE HYDROCHLORIDE (AvPAK), GUANFACINE HYDROCHLORIDE (Bora Pharmaceutical Laboratories), GUANFACINE HYDROCHLORIDE (Chartwell RX), GUANFACINE HYDROCHLORIDE (NuCare Pharmaceuticals), GUANFACINE HYDROCHLORIDE (Precision Dose), GUANFACINE HYDROCHLORIDE (REMEDYREPACK), GUANFACINE HYDROCHLORIDE (REMEDYREPACK), GUANFACINE HYDROCHLORIDE (TWi Pharmaceuticals), GUANFACINE HYDROCHLORIDE (Unichem Pharmaceuticals (USA))
Formula
C9H9Cl2N3O. HCl
Exact mass
280.9889
Mol weight
282.5542
Structure
Simcomp
Class
Cardiovascular agent
 DG01738  Centrally-acting antiadrenergic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
Therapeutic category: 1179
ATC code: C02AC02
Chemical structure group: DG00250
Product (DG00250): D00606<JP/US>
Efficacy
Antihypertensive, alpha2-Adrenergic receptor agonist
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Hypertension [DS:H01633]
Comment
Guanidine derivative
Target
ADRA2A [HSA:150] [KO:K04138]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AC Imidazoline receptor agonists
     C02AC02 Guanfacine
      D00606  Guanfacine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Guanfacine
    D00606  Guanfacine hydrochloride (JAN/USP)
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non-amphetamines
   Guanfacine
    D00606  Guanfacine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00606  Guanfacine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00250  Guanfacine
    D00606  Guanfacine hydrochloride
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00250  Guanfacine
      D00606  Guanfacine hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00250  Guanfacine
     D00606  Guanfacine hydrochloride
  DG02925  CYP3A5 substrate
   DG00250  Guanfacine
    D00606  Guanfacine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2A
     D00606  Guanfacine hydrochloride (JAN/USP) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00606
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00606
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00606
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00250  Guanfacine
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00250  Guanfacine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00250  Guanfacine
  DG02925  CYP3A5 substrate
   DG00250  Guanfacine
Other DBs
CAS: 29110-48-3
PubChem: 7847672
ChEBI: 5559
LigandBox: D00606
NIKKAJI: J262.680B
KCF data

ATOM        16
            1   C8y C    24.2186  -16.1239
            2   C1b C    23.0015  -15.4193
            3   C8y C    24.2070  -17.5156
            4   C8y C    25.4239  -15.4134
            5   C5a C    21.7961  -16.1239
            6   C8x C    25.4239  -18.2144
            7   X   Cl   22.9956  -18.2087
            8   C8x C    26.6353  -16.1122
            9   X   Cl   25.4182  -14.0101
            10  N1b N    20.5848  -15.4193
            11  O5a O    21.7961  -17.5215
            12  C8x C    26.6353  -17.5156
            13  C2c C    19.3677  -16.1239
            14  N1a N    18.1565  -15.4193
            15  N2a N    19.3677  -17.5215
            16  X   Cl   29.0752  -16.4966
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 2
            15    8  12 1

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