 | | DRUG: Amlodipine besylate | |
| Entry |
|
|---|
| Name |
Amlodipine besylate (USP);
Amlodipine besilate (JP18);
Norvasc (TN) |
|---|
| Product |
|
|---|
| Generic |
AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (A-S Medication Solutions), AMLODIPINE BESYLATE (ACI Healthcare USA), AMLODIPINE BESYLATE (American Health Packaging), AMLODIPINE BESYLATE (Amneal Pharmaceuticals LLC), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Aphena Pharma Solutions - Tennessee), AMLODIPINE BESYLATE (Ascend Laboratories), AMLODIPINE BESYLATE (Aurobindo Pharma Limited), AMLODIPINE BESYLATE (AvKARE), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Bryant Ranch Prepack), AMLODIPINE BESYLATE (Cardinal Health 107), AMLODIPINE BESYLATE (Cipla USA), AMLODIPINE BESYLATE (Cipla USA), AMLODIPINE BESYLATE (DIRECT RX), AMLODIPINE BESYLATE (DIRECT RX), AMLODIPINE BESYLATE (Denton Pharma), AMLODIPINE BESYLATE (Denton Pharma), AMLODIPINE BESYLATE (DirectRX), AMLODIPINE BESYLATE (Direct_Rx), AMLODIPINE BESYLATE (Direct_Rx), AMLODIPINE BESYLATE (Direct_Rx), AMLODIPINE BESYLATE (Epic Pharma), AMLODIPINE BESYLATE (Exelan Pharmaceuticals), AMLODIPINE BESYLATE (Exelan Pharmaceuticals), AMLODIPINE BESYLATE (Greenstone LLC), AMLODIPINE BESYLATE (Lake Erie Medical DBA Quality Care Products LLC), AMLODIPINE BESYLATE (Legacy Pharmaceutical Packaging), AMLODIPINE BESYLATE (Legacy Pharmaceutical Packaging), AMLODIPINE BESYLATE (Major Pharmaceuticals), AMLODIPINE BESYLATE (NCS HealthCare of KY), AMLODIPINE BESYLATE (NCS HealthCare of KY), AMLODIPINE BESYLATE (Northwind Pharmaceuticals), AMLODIPINE BESYLATE (Northwind Pharmaceuticals), AMLODIPINE BESYLATE (Northwind Pharmaceuticals), AMLODIPINE BESYLATE (Northwind Pharmaceuticals), AMLODIPINE BESYLATE (Northwind Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (NuCare Pharmaceuticals), AMLODIPINE BESYLATE (Oxford Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (PD-Rx Pharmaceuticals), AMLODIPINE BESYLATE (POLYGEN PHARMACEUTICALS), AMLODIPINE BESYLATE (Pharmasource Meds), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Preferred Pharmaceuticals), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (Proficient Rx LP), AMLODIPINE BESYLATE (QPharma), AMLODIPINE BESYLATE (Quality Care Products), AMLODIPINE BESYLATE (Quality Care Products), AMLODIPINE BESYLATE (Quallent Pharmaceuticals Health LLC), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (REMEDYREPACK), AMLODIPINE BESYLATE (RPK Pharmaceuticals), AMLODIPINE BESYLATE (RPK Pharmaceuticals), AMLODIPINE BESYLATE (RPK Pharmaceuticals), AMLODIPINE BESYLATE (RPK Pharmaceuticals), AMLODIPINE BESYLATE (Redpharm Drug), AMLODIPINE BESYLATE (St. Mary's Medical Park Pharmacy), AMLODIPINE BESYLATE (St. Mary's Medical Park Pharmacy), AMLODIPINE BESYLATE (St. Mary's Medical Park Pharmacy), AMLODIPINE BESYLATE (Teva Pharmaceuticals), AMLODIPINE BESYLATE (Unichem Pharmaceuticals (USA)), AMLODIPINE BESYLATE (Zydus Lifesciences Limited), AMLODIPINE BESYLATE (Zydus Pharmaceuticals USA) |
|---|
| Formula |
C20H25ClN2O5. C6H6O3S
|
|---|
| Exact mass |
566.149
|
|---|
| Mol weight |
567.0509
|
|---|
| Structure |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2171 |
| Product (DG00322): | D00615<JP/US> D11881<US> |
| Product (mixture): | D07569<JP> D08488<JP/US> D09743<JP/US> D09745<JP/US> D10243<JP> D10285<US> D10286<US> D10288<US> D10524<JP> D10805<JP> D11069<US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Disease |
|
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA01 Amlodipine
D00615 Amlodipine besylate (USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Calcium Channel Blocking Agents, Dihydropyridines
Amlodipine
D00615 Amlodipine besylate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
217 Vasodilators
2171 Coronary dilators
D00615 Amlodipine besylate (USP); Amlodipine besilate (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00322 Amlodipine
D00615 Amlodipine besylate
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00322 Amlodipine
D00615 Amlodipine besylate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00322 Amlodipine
D00615 Amlodipine besylate
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D00615 Amlodipine besylate
DG03231 Antihypertensive
D00615 Amlodipine besylate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D00615 Amlodipine besylate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00615 Amlodipine besylate
D00615 Amlodipine besylate tablets
D00615 Amlodipine besilate orally disintegrating tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00615
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00322 Amlodipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00322 Amlodipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00322 Amlodipine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 38
1 C8y C 29.5695 -18.6304
2 C8x C 28.3142 -19.3278
3 C8x C 30.7550 -19.3278
4 S4a S 29.5698 -17.2357
5 C8x C 28.3142 -20.6528
6 C8x C 30.7550 -20.6528
7 O1d O 29.5698 -15.8409
8 O1d O 28.1750 -17.2357
9 O1d O 30.9645 -17.2357
10 C8x C 29.5695 -21.3502
11 C1y C 19.3368 -16.0762
12 C2y C 20.5198 -15.3803
13 C2y C 18.1539 -15.3803
14 C8y C 19.3368 -18.4421
15 C2y C 20.5198 -13.9886
16 C7a C 21.7028 -16.0762
17 C2y C 18.1539 -13.9886
18 C7a C 16.9709 -16.0066
19 C8y C 20.5198 -19.1380
20 C8x C 18.1539 -19.1380
21 N1x N 19.3368 -13.2927
22 C1b C 21.7028 -13.2927
23 O7a O 22.8858 -15.3803
24 O6a O 21.7028 -17.3983
25 C1a C 16.9709 -13.2927
26 O7a O 15.7879 -15.3803
27 O6a O 16.9709 -17.3983
28 C8x C 20.5198 -20.4601
29 X Cl 21.7028 -18.4421
30 C8x C 18.1539 -20.4601
31 O2a O 22.8858 -13.9886
32 C1b C 24.0687 -16.0762
33 C1a C 14.6049 -16.0066
34 C8x C 19.3368 -21.1560
35 C1b C 24.0687 -13.2927
36 C1a C 25.2517 -15.3803
37 C1b C 25.2517 -13.9886
38 N1a N 26.4347 -13.2927
BOND 39
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 3 6 1
6 4 7 1
7 4 8 2
8 4 9 2
9 5 10 1
10 6 10 2
11 11 12 1
12 11 13 1
13 11 14 1
14 12 15 2
15 12 16 1
16 13 17 2
17 13 18 1
18 14 19 1
19 14 20 2
20 15 21 1
21 15 22 1
22 16 23 1
23 16 24 2
24 17 25 1
25 18 26 1
26 18 27 2
27 19 28 2
28 19 29 1
29 20 30 1
30 22 31 1
31 23 32 1
32 26 33 1
33 28 34 1
34 31 35 1
35 32 36 1
36 35 37 1
37 37 38 1
38 17 21 1
39 30 34 2
|
|---|
|
» Japanese version » Back
|
|