KEGG   DRUG: Diltiazem hydrochloride
Entry
D00616                      Drug                                   
Name
Diltiazem hydrochloride (JP18/USP);
Cardizem (TN);
Cartia XT (TN);
Dilacor XR (TN);
Dilt-CD (TN)
Product
CARDIZEM (Bausch Health US LLC), CARDIZEM CD (Bausch Health US LLC), CARDIZEM LA (Bausch Health US LLC), DILTIAZEM HCL CD (Bryant Ranch Prepack), DILTIAZEM HCL CD (Oceanside Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Exela Pharma Sciences), TIAZAC (Bausch Health US)
  Generic
CARTIA (Actavis Pharma), CARTIA XT (DirectRx), DILTIAZEM HCI (HF Acquisition Co LLC), DILTIAZEM HCI (HF Acquisition Co LLC), DILTIAZEM HCL ER (Direct_Rx), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (Accord Healthcare), DILTIAZEM HYDROCHLORIDE (Actavis Pharma), DILTIAZEM HYDROCHLORIDE (American Health Packaging), DILTIAZEM HYDROCHLORIDE (American Health Packaging), DILTIAZEM HYDROCHLORIDE (Apotex Corp.), DILTIAZEM HYDROCHLORIDE (Athenex Pharmaceutical Division), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Cardinal Health 107), DILTIAZEM HYDROCHLORIDE (Cipla USA), DILTIAZEM HYDROCHLORIDE (Denton Pharma), DILTIAZEM HYDROCHLORIDE (Edenbridge Pharmaceuticals LLC.), DILTIAZEM HYDROCHLORIDE (Eugia US LLC), DILTIAZEM HYDROCHLORIDE (GLENMARK PHARMACEUTICALS), DILTIAZEM HYDROCHLORIDE (Golden State Medical Supply), DILTIAZEM HYDROCHLORIDE (Hikma Pharmaceuticals USA), DILTIAZEM HYDROCHLORIDE (Hikma Pharmaceuticals USA), DILTIAZEM HYDROCHLORIDE (Hospira), DILTIAZEM HYDROCHLORIDE (Ingenus Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Major Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), DILTIAZEM HYDROCHLORIDE (Medical Purchasing Solutions), DILTIAZEM HYDROCHLORIDE (Medical Purchasing Solutions), DILTIAZEM HYDROCHLORIDE (Mylan Institutional), DILTIAZEM HYDROCHLORIDE (Mylan Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NCS HealthCare of KY), DILTIAZEM HYDROCHLORIDE (NCS HealthCare of KY), DILTIAZEM HYDROCHLORIDE (NORTHSTAR RX LLC), DILTIAZEM HYDROCHLORIDE (Northstar Rx LLC), DILTIAZEM HYDROCHLORIDE (Northwind Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Northwind Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Northwind Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (OCEANSIDE PHARMACEUTICALS), DILTIAZEM HYDROCHLORIDE (Oceanside Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Oceanside Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Oceanside Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Par Pharmaceutical), DILTIAZEM HYDROCHLORIDE (Preferred Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Proficient Rx LP), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (RPK Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (ScieGen Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (ScieGen Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Slate Run Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Slate Run Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Sun Pharmaceutical Industries), DILTIAZEM HYDROCHLORIDE (Sun Pharmaceutical Industries), DILTIAZEM HYDROCHLORIDE (Sun Pharmaceutical Industries), DILTIAZEM HYDROCHLORIDE (TWi Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (TWi Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Teva Pharmaceuticals USA), DILTIAZEM HYDROCHLORIDE (Zydus Lifesciences Limited), DILTIAZEM HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), DILTIAZEM HYDROCHLORIDE EXTENDED RELEASE (direct rx), DILTIAZEM HYDROCHLORIDE EXTENDED-RELEASE (AvKARE), DILTIAZEM HYDROCHLORIDE EXTENDED-RELEASE (Mayne Pharma), MATZIM LA (Actavis Pharma), TAZTIA (Actavis Pharma), TIADYLT ER (Bryant Ranch Prepack), TIADYLT ER (Zydus Lifesciences Limited), TIADYLT ER (Zydus Pharmaceuticals (USA))
Formula
C22H26N2O4S. HCl
Exact mass
450.138
Mol weight
450.9788
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
 DG01653  Antiarrhythmics
 DG03231  Antihypertensive
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2171
ATC code: C05AE03 C08DB01
Chemical structure group: DG00331
Product (DG00331): D00616<JP/US>
Efficacy
Antiarrhythmic, Antihypertensive, Vasodilator (coronary), Calcium channel blocker
  Disease
Hypertension [DS:H01633]
Angina [DS:H01632]
Comment
Benzodiazepine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04024  cAMP signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07036  Calcium channel blocking drugs
map07037  Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AE Muscle relaxants
     C05AE03 Diltiazem
      D00616  Diltiazem hydrochloride (JP18/USP) <JP/US>
  C08 CALCIUM CHANNEL BLOCKERS
   C08D SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
    C08DB Benzothiazepine derivatives
     C08DB01 Diltiazem
      D00616  Diltiazem hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class IV
    Diltiazem
     D00616  Diltiazem hydrochloride (JP18/USP)
  Calcium Channel Blocking Agents, Nondihydropyridines
   Diltiazem
    D00616  Diltiazem hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00616  Diltiazem hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01496  Calcium channel L type blocker
    DG00331  Diltiazem
     D00616  Diltiazem hydrochloride
  DG01653  Antiarrhythmics
   DG00331  Diltiazem
    D00616  Diltiazem hydrochloride
  DG03231  Antihypertensive
   DG00331  Diltiazem
    D00616  Diltiazem hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00331  Diltiazem
     D00616  Diltiazem hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00616  Diltiazem hydrochloride
  DG01653  Antiarrhythmics
   D00616  Diltiazem hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D00616  Diltiazem hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00616  Diltiazem hydrochloride
  D00616  Diltiazem hydrochloride extended-release capsules
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00616
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01496  Calcium channel L type blocker
    DG00331  Diltiazem
  DG01653  Antiarrhythmics
   DG00331  Diltiazem
  DG03231  Antihypertensive
   DG00331  Diltiazem
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00331  Diltiazem
Other DBs
CAS: 33286-22-5
PubChem: 7847682
ChEBI: 645509
LigandBox: D00616
NIKKAJI: J253.795H
KCF data

ATOM        30
            1   C5x C    26.2434  -16.0394
            2   C1y C    25.4013  -14.9298
            3   C1y C    25.7365  -13.5730
            4   S2x S    26.9975  -12.9949
            5   N1y N    27.6492  -16.0646
            6   C8y C    28.2511  -13.6172
            7   C8y C    28.5376  -14.9859
            8   C8x C    29.8688  -15.4230
            9   C8x C    30.9130  -14.4886
            10  C8x C    30.6266  -13.1199
            11  C8x C    29.2952  -12.6828
            12  O5x O    25.5217  -17.2390
            13  C1b C    28.3273  -17.2894
            14  C8y C    24.7294  -12.6046
            15  C8x C    24.7294  -11.2046
            16  C8x C    23.5170  -10.5046
            17  C8y C    22.3045  -11.2046
            18  C8x C    22.3045  -12.6046
            19  C8x C    23.5170  -13.3046
            20  O2a O    21.1094  -10.5143
            21  C1a C    19.9260  -11.1974
            22  O7a O    24.0425  -15.2100
            23  C7a C    23.6044  -16.5300
            24  C1a C    22.2214  -16.8149
            25  O6a O    24.5233  -17.5636
            26  C1b C    29.7498  -17.3149
            27  N1c N    30.4175  -18.5206
            28  C1a C    31.8500  -18.5456
            29  C1a C    29.6920  -19.7271
            30  X   Cl   24.6400  -19.5300
BOND        31
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    6  11 2
            13    1  12 2
            14    5  13 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21    3  14 1 #Down
            22   17  20 1
            23   20  21 1
            24    2  22 1 #Down
            25   22  23 1
            26   23  24 1
            27   23  25 2
            28   13  26 1
            29   26  27 1
            30   27  28 1
            31   27  29 1

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Disease (2)   
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   NIKKAJI (1)   
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