| Entry |
|
|---|
| Name |
Nisoldipine (JAN/USAN/INN);
Sular (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C20H24N2O6
|
|---|
| Exact mass |
388.1634
|
|---|
| Mol weight |
388.4144
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Disease |
|
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA07 Nisoldipine
D00618 Nisoldipine (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Calcium Channel Blocking Agents, Dihydropyridines
Nisoldipine
D00618 Nisoldipine (JAN/USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
D00618 Nisoldipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
D00618 Nisoldipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00618 Nisoldipine
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D00618 Nisoldipine
DG03231 Antihypertensive
D00618 Nisoldipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D00618 Nisoldipine (JAN/USAN/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00618
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C1y C 23.9681 -15.8359
2 C8y C 23.9564 -18.2346
3 C2y C 25.1147 -15.1866
4 C2y C 22.8213 -15.1866
5 C8y C 22.8038 -18.8958
6 C8x C 25.0972 -18.8958
7 C2y C 25.1147 -13.8642
8 C7a C 26.2614 -15.8359
9 C2y C 22.8213 -13.8642
10 C7a C 21.6862 -15.8359
11 C8x C 22.8038 -20.2063
12 N2b N 21.6805 -18.2346 #+
13 C8x C 25.0972 -20.2063
14 N1x N 23.9681 -13.2032
15 C1a C 26.2614 -13.2032
16 O7a O 27.3965 -15.1866
17 O6a O 26.2614 -17.1640
18 C1a C 21.6862 -13.2032
19 O7a O 20.5454 -15.1866
20 O6a O 21.6922 -17.0644
21 C8x C 23.9564 -20.8790
22 C1b C 28.5314 -15.8359
23 C1a C 19.4046 -15.8359
24 C1c C 29.6664 -15.1806
25 C1a C 30.8073 -15.8301
26 C1a C 29.6605 -13.8642
27 O3a O 20.4917 -18.9072 #-
28 O3a O 23.0904 -17.1047
BOND 29
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 2
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 1
15 8 16 1
16 8 17 2
17 9 18 1
18 10 19 1
19 10 20 2
20 11 21 1
21 16 22 1
22 19 23 1
23 22 24 1
24 24 25 1
25 24 26 1
26 9 14 1
27 13 21 2
28 12 27 1
29 12 28 2
|
|---|
