KEGG   DRUG: Mexiletine hydrochloride
Entry
D00639                      Drug                                   
Name
Mexiletine hydrochloride (JP18/USP);
Mexitil (TN)
Product
  Generic
MEXILETINE HYDROCHLORIDE (ANI Pharmaceuticals), MEXILETINE HYDROCHLORIDE (American Health Packaging), MEXILETINE HYDROCHLORIDE (AvKARE), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Bryant Ranch Prepack), MEXILETINE HYDROCHLORIDE (Camber Pharmaceuticals), MEXILETINE HYDROCHLORIDE (Chartwell RX), MEXILETINE HYDROCHLORIDE (Golden State Medical Supply), MEXILETINE HYDROCHLORIDE (Ingenus Pharmaceuticals), MEXILETINE HYDROCHLORIDE (Lannett Company), MEXILETINE HYDROCHLORIDE (Leading Pharma), MEXILETINE HYDROCHLORIDE (Marlex Pharmaceuticals), MEXILETINE HYDROCHLORIDE (Senores Pharmaceuticals), MEXILETINE HYDROCHLORIDE (Sun Pharmaceutical Industries), MEXILETINE HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
C11H17NO. HCl
Exact mass
215.1077
Mol weight
215.7197
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 1900 2129
ATC code: C01BB02
Chemical structure group: DG00197
Product (DG00197): D00639<JP/US>
Efficacy
Antiarrhythmic, Antihypertensive, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB02 Mexiletine
      D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class I
    Mexiletine
     D00639  Mexiletine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  19  Other agents affecting nervous system and sensory organs
   190  Other agents affecting nervous system and sensory organs
    1900  Other agents affecting nervous system and sensory organs
     D00639  Mexiletine hydrochloride (JP18/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00639  Mexiletine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00197  Mexiletine
      D00639  Mexiletine hydrochloride
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00197  Mexiletine
    D00639  Mexiletine hydrochloride
  DG01644  CYP2D6 substrate
   DG00197  Mexiletine
    D00639  Mexiletine hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   D00639  Mexiletine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
    SCN2A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
    SCN3A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
    SCN4A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
    SCN5A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
    SCN8A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
    SCN9A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
    SCN10A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
    SCN11A
     D00639  Mexiletine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00639  Mexiletine hydrochloride
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00639
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00639
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00197  Mexiletine
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00197  Mexiletine
  DG01644  CYP2D6 substrate
   DG00197  Mexiletine
Other DBs
CAS: 5370-01-4
PubChem: 7847705
ChEBI: 6917
LigandBox: D00639
NIKKAJI: J220.000G
KCF data

ATOM        14
            1   C8y C    22.8402  -16.9926
            2   C8y C    21.6292  -17.7005
            3   C8y C    22.8402  -15.6003
            4   O2a O    24.0511  -17.6946
            5   C8x C    20.4125  -16.9926
            6   C1a C    21.6292  -19.0986
            7   C8x C    21.6292  -14.8984
            8   C1a C    24.0511  -14.8984
            9   C1b C    25.2563  -16.9926
            10  C8x C    20.4125  -15.6003
            11  C1c C    26.4730  -17.6946
            12  C1a C    26.4730  -19.0986
            13  N1a N    27.6840  -16.9926
            14  X   Cl   31.3883  -16.8932
BOND        13
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 2
            10    9  11 1
            11   11  12 1
            12   11  13 1
            13    7  10 1

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