| | DRUG: Propafenone hydrochloride | |
Entry |
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Name |
Propafenone hydrochloride (JP18/USP); Rythmol (TN) |
Product |
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Generic |
PROPAFENONE HCL (Actavis Pharma), PROPAFENONE HYDROCHLORIDE (A-S Medication Solutions), PROPAFENONE HYDROCHLORIDE (ANI Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Actavis Pharma), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (Aurobindo Pharma Limited), PROPAFENONE HYDROCHLORIDE (Aurobindo Pharma Limited), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Glenmark Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Northstar Rx LLC), PROPAFENONE HYDROCHLORIDE (Par Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Par Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Proficient Rx LP), PROPAFENONE HYDROCHLORIDE (Rising Pharma Holdings), PROPAFENONE HYDROCHLORIDE (Strides Pharma Science Limited), PROPAFENONE HYDROCHLORIDE (Strides Pharma Science Limited), PROPAFENONE HYDROCHLORIDE (Sun Pharmaceutical Industries), PROPAFENONE HYDROCHLORIDE (TWi Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Upsher-Smith Laboratories), PROPAFENONE HYDROCHLORIDE (Vitruvias Therapeutics), PROPAFENONE HYDROCHLORIDE (Zydus Lifesciences Limited), PROPAFENONE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)) |
Formula |
C21H27NO3. HCl
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Exact mass |
377.1758
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Mol weight |
377.9049
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Structure |
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Simcomp |
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Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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Remark |
Therapeutic category: | 2129 |
Product (DG00200): | D00640<JP/US> |
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Efficacy |
Antiarrhythmic, Sodium channel blocker |
Target |
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Pathway |
hsa04261 | Adrenergic signaling in cardiomyocytes |
|
Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544]
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Interaction |
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Structure map |
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Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BC Antiarrhythmics, class Ic
C01BC03 Propafenone
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Antiarrhythmics
Vaughn Williams-Class I
Propafenone
D00640 Propafenone hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D00640 Propafenone hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
DG00200 Propafenone
D00640 Propafenone hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00200 Propafenone
D00640 Propafenone hydrochloride
DG01644 CYP2D6 substrate
DG00200 Propafenone
D00640 Propafenone hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00200 Propafenone
D00640 Propafenone hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D00640 Propafenone hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
SCN2A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
SCN3A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
SCN4A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
SCN5A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
SCN8A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
SCN9A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
SCN10A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
SCN11A
D00640 Propafenone hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00640 Propafenone hydrochloride
D00640 Propafenone hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00640
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00640
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
DG00200 Propafenone
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00200 Propafenone
DG01644 CYP2D6 substrate
DG00200 Propafenone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00200 Propafenone
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Other DBs |
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KCF data |
ATOM 26
1 C8y C 27.3415 -18.7772
2 C8y C 27.3474 -20.1862
3 O2a O 26.1247 -18.0844
4 C8x C 28.5641 -18.0785
5 C5a C 26.1363 -20.8906
6 C8x C 28.5641 -20.8849
7 C1b C 26.1363 -16.6871
8 C8x C 29.7753 -18.7772
9 C1b C 24.9311 -20.1919
10 O5a O 26.1422 -22.2880
11 C8x C 29.7693 -20.1803
12 C1c C 24.9311 -15.9825
13 C1b C 23.7259 -20.8965
14 C1b C 23.7259 -16.6928
15 O1a O 24.9253 -14.5851
16 C8y C 22.5090 -20.2036
17 N1b N 22.5149 -15.9941
18 C8x C 22.5090 -18.8005
19 C8x C 21.3097 -20.9082
20 C1b C 21.3097 -16.6987
21 C8x C 21.2921 -18.1135
22 C8x C 20.0869 -20.2212
23 C1b C 20.0928 -16.0000
24 C8x C 20.0754 -18.8121
25 C1a C 18.8819 -16.7045
26 X Cl 31.8596 -18.4395
BOND 26
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 1
7 4 8 1
8 5 9 1
9 5 10 2
10 6 11 1
11 7 12 1
12 9 13 1
13 12 14 1
14 12 15 1
15 13 16 1
16 14 17 1
17 16 18 2
18 16 19 1
19 17 20 1
20 18 21 1
21 19 22 2
22 20 23 1
23 21 24 2
24 23 25 1
25 8 11 2
26 22 24 1
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